Senior Research Associate / Associate Scientist – Mol Bio & Expression

Location: Redwood City 

Company Overview: 

ImmunEdge is a biopharmaceutical company committed to developing novel therapeutics for patients with serious or life-threatening diseases. With a highly experienced team of experts in immunology and drug development, we are pioneering innovative approaches to target and modulate key molecular pathways that regulate the immune response.  

At ImmunEdge, we are driven by a shared commitment to improving human health through innovative science. We are building a culture based on kindness, collaboration, and a deep passion for advancing science. As an early joiner to the company, you will help cultivate an environment where every team member is encouraged to challenge ideas, think critically, and contribute their unique perspectives. We value openness, transparency, and continuous learning, and want to empower our employees to take ownership of their work while fostering a sense of community and teamwork. Whether you’re working in the lab, the office, or across functional teams, you will find an inclusive space where your contributions matter and your professional growth is supported. 

Join us in shaping the future of biotechnology. Together, we can change lives. 

Position: 

We are seeking a motivated and detail-oriented Senior Research Associate / Associate Scientist to join the Biotherapeutics group and support antibody drug development programs. The successful candidate will play a key role in protein and antibody cloning and expression. In this role you will help optimize and advance expression platforms through evaluation of cell lines and culture conditions, vector engineering and maintain our molecules archive and databases while keeping rigorous experimental documentation in a collaborative industry research environment. 

Key Responsibilities: 

• Design and clone protein variants and expression vectors, both internally and in collaboration with external partners. 

• Prepare DNA for transient and stable expression workflows. 

• Maintain mammalian cell lines for protein expression and functional assays. 

• Execute protein expression using transient and stable cell lines at various scales. 

• Support the optimization and advancement of the expression platform by evaluating different cell lines, culture conditions, and expression parameters. 

• Register, track, and manage inventories of expression vectors, DNA and protein sequences, and cell lines using electronic lab notebooks. 

• Measure protein expression titers using BLI and/or ELISA. 

• Perform data analysis and visualization using GraphPad Prism; interpret results and clearly communicate findings to project teams. 

• Communicate clearly and proactively with scientists across the protein production workflow to ensure smooth handoffs and timely execution. 

• Maintain accurate, complete, and well-organized experimental records in electronic lab notebooks. 

• Collaborate with scientists and cross-functional team members to advance biotherapeutics programs. 

• Provide additional support for antibody drug development efforts as needed, including protein purification and other antibody characterization activities. 

Qualifications: 

• Bachelor’s or Master’s degree in Biology, Biochemistry, Biotechnology, or a related scientific discipline. 

• Minimum of 2 years of hands-on laboratory experience in a biotechnology or pharmaceutical industry setting; level and title will be commensurate with experience. 

• Demonstrated hands-on experience with protein and antibody production using Expi293 and ExpiCHO cell lines. 

• Strong molecular biology skills, including primer and construct design, cloning, and preparation of high-quality DNA at various scales. 

• Hands-on experience with standard curve preparation and protein titer measurement using BLI. 

• Proficiency in GraphPad Prism for data analysis, curve fitting, and data visualization. 

• Strong data analysis, documentation, and organizational skills, with close attention to detail. 

• Ability to work independently with minimal supervision while collaborating effectively in a team environment. 

Nice to Have Skills 

• Experience with analytical characterization techniques, including HPLC-SEC, HPLC-HIC, and SDS-PAGE 

• Experience with FACS-based binding assays to evaluate antibody binding to cell surface targets and support functional characterization 

• Experience with ELISA-based assays in multiple formats to support antibody characterization 

• Familiarity with antibody discovery and biotherapeutics development workflows 

Expected Salary Range: $107,000 - $120,000 

We encourage candidates of all levels to apply as there is sometimes flexibility on job level and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications, internal equity, and location.  

ImmunEdge offers a competitive employment package that includes an annual bonus plan, equity, and a generous benefits package including comprehensive health (medical, dental, and vision) insurance for our employees and their families, a 401k plan, FSA plans (medical, dependent), an Employee Assistance Plan, and a holiday and paid time off plan. 

At ImmunEdge, we believe that a diverse, open, and inclusive environment and culture is key to our success.  We will not be influenced in recruiting, hiring, promoting or any other employment practices by race, color, citizenship status, national origin, ancestry, sex, sexual orientation, gender identity/expression, age, religion, physical or mental disability, medical or genetic condition, marital status, veteran status, or any other characteristics protected under applicable federal, state and local laws. ImmunEdge will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable laws. 

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.