An exciting opportunity for an enthusiastic scientist to join the Cell Metrology team within the National Measurement Laboratory (NML) at LGC, based at Nexus, University of Leeds innovation hub. We are looking for an early career post-graduate cell biologist with flow cytometry and cell sorting experience who can assist in developing and improving quantitative methods for cell-based measurements for national and international standardisation initiatives and for stakeholder collaborations and commercial services. Current research efforts are focused on addressing fundamental and emerging cell measurement challenges and particularly, optimising single cell measurements through use of cell culture and bio-imaging techniques such as flow cytometry and confocal microscopy to identify key cell critical quality attributes.
Job Description- Independent day-to-day planning and delivery of work.
- Responsible for conducting analytical work including method development and validation, biological specimen preparation, data acquisition and subsequent data analysis for flow cytometry and cell sorting.
- Create working instructions and maintain laboratory notebooks.
- Contribute to scientific writing to produce publications and client reporting and represent the team in internal and external events.
- Contribute to the maintenance of quality, health, and safety records, adhering to ISO9001 quality management system.
- Participate in maintaining cleaning procedures, ordering consumables and general upkeep of the laboratory.
- Responsible for routine maintenance to determine system performance, service contracts, operation and troubleshooting of flow cytometry and cell sorting instruments.
Training will be provided, as appropriate, on traceability of measurements to the System of International Units, uncertainty estimation workflows, instrument software packages and on quality management systems required for the delivery of the projects.
This represents a good opportunity for candidates looking to progress their career in cell-based measurements and the potential to lead future projects. There is also an opportunity for the individual to undertake a part‑time PhD with an academic partner after completing a couple of years in the organisation.
QualificationsThe successful candidate will have relevant industrial experience in cell culture and designing and performing multi-parametric flow cytometry panels in a variety of samples.
The candidate will be able to demonstrate the following attributes:
Essential:
- Proficiency in running, troubleshooting flow cytometry and cell sorting instrumentation.
- Extensive cell culture experience using adherent and suspension mammalian cell lines and primary cells.
- Good understanding of cell characterisation and enumeration techniques.
- Proficiency in method development and validation skills with a keen interest in improving methodology/practices.
- High level of organisation regarding sample preparation, data collection and data analysis.
- Ability to work effectively in a team environment and work collaboratively in cross-functional teams.
- Willingness to learn new techniques and integrate into existing processes
Desirable:
- Proficiency in the use of FCSExpress, FlowJo, CytExpert or Attune software for flow cytometry data analysis.
- Experience of using the Attune, Cytoflex and BD FACS melody instrumentation.
- Experience in using cell imaging techniques such as brightfield, widefield and confocal microscopy.
- Experience of producing peer review publications and presenting (poster and presentation) work internally or externally.
Additional Information
About LGC:
LGC is a leading, global life science tools company, providing mission-critical components and solutions into high-growth application areas across the human healthcare and applied market segments. Its high-quality product portfolio is comprised of mission-critical tools for genomic analysis and for quality assurance applications, which are typically embedded and recurring within our customers’ products and workflows and are valued for their performance, quality, and range.
Skills Required
- Proficiency in running and troubleshooting flow cytometry and cell sorting instrumentation.
- Extensive cell culture experience with adherent, suspension mammalian cell lines and primary cells.
- Experience designing and performing multi-parametric flow cytometry panels.
- Good understanding of cell characterisation and enumeration techniques.
- Proficiency in method development and validation.
- High level of organisation for sample preparation, data collection and data analysis.
- Ability to work effectively and collaboratively in cross-functional teams.
- Maintain laboratory notebooks, create working instructions and adhere to quality systems (ISO9001).
- Routine maintenance, performance checks and troubleshooting of flow cytometry and cell sorting instruments.
- Willingness to learn new techniques and integrate into existing processes.
- Proficiency in FCSExpress, FlowJo, CytExpert or Attune software for flow cytometry data analysis.
- Experience using Attune, Cytoflex and BD FACS Melody instrumentation.
- Experience with cell imaging techniques such as brightfield, widefield and confocal microscopy.
- Experience producing peer-reviewed publications and presenting scientific work.
LGC Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about LGC and has not been reviewed or approved by LGC.
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Healthcare Strength — Health, dental, and vision coverage with FSA/HSA options are consistently part of the package, and private medical is cited where applicable in the UK. Coverage is often characterized as solid alongside other core benefits.
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Retirement Support — Retirement offerings include a 401(k) with employer contribution in the U.S. and pension schemes in the UK, complemented by life and disability insurance. These elements are highlighted as part of a standard-to-competitive core package.
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Leave & Time Off Breadth — Paid time off, holidays, sick leave, and family leave are broadly available, with some sites offering a year‑end shutdown. Flexibility and local leave programs contribute to a generally well-rounded time‑off offering.
LGC Insights
What We Do
LGC is a leading, global life science tools company, providing mission-critical components and solutions into high-growth application areas across the human healthcare and applied market segments. Its high quality product portfolio is comprised of mission-critical tools for genomic analysis and for quality assurance applications, which are typically embedded and recurring within our customers’ products and workflows and are valued for their performance, quality and range. LGC’s tools play a key role in customer workflows from discovery applications through to commercial manufacture and enable its customers to: bring new diagnostics and therapies to market; progress research and development; optimise food production; and continuously monitor and enhance the quality of food, the environment and consumer products. LGC’s 175+ years of scientific heritage, combined with a track record of innovation and value-enhancing acquisitions, has enabled the company to build its product portfolio and expertise, and develop deep relationships with customers, industry partners and the global scientific community. LGC’s core purpose of Science for a safer world and its core values of passion, curiosity, integrity, brilliance and respect, drive its culture. As of 30 June 2021, it employs 4,350 employees, of which over 1,175 employees hold PhD and/or master’s degrees. Its products and services are delivered by highly qualified and experienced teams, operating from a global network of accredited sites that showcase its scientific and manufacturing capabilities.
