Senior Project Manager - PMO (Phoenix)

At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives.

We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting-edge molecular science and AI, we ask ourselves every day: “What would I do if this patient were my mom?” That question drives everything we do.

But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose.

Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins.

Position Summary
The Senior Project Manager is a strategic leader responsible for driving enterprise-level initiatives that advance Caris’ precision medicine portfolio and operational capabilities. This role leads programs from concept through execution, aligning business goals, product requirements, regulatory and quality expectations, technical deliverables, and launch readiness across internal and external stakeholders.

The ideal candidate brings strong program leadership, sound judgment in regulated and fast-moving environments, and the ability to translate ambiguity into clear plans, decisions, accountability, and results. This individual will partner closely with leaders across product development, translational science, bioinformatics/software, laboratory operations, quality, regulatory, and commercial-facing functions to deliver programs that are high quality, on time, and aligned to business and patient impact.
Job Responsibilities

• This role has high visibility across the organization and is expected to influence leaders, drive clarity in complex initiatives, and help scale program execution in support of Caris’ strategic priorities.

• Lead complex, regulated programs from initiation through execution, ensuring alignment on scope, milestones, risks, dependencies, resource needs, and business outcomes.

• Translate strategic objectives and product requirements into actionable project plans, governance structures, timelines, and workstream deliverables.

• Partner with leaders across product development, translational science, laboratory operations, bioinformatics/software, quality, regulatory, and other business functions to drive execution in a highly collaborative environment.

• Drive program governance by facilitating core team meetings, documenting key decisions and actions, maintaining accountability, and escalating critical issues with recommended solutions.

• Manage interdependencies across teams and vendors, proactively identifying execution risks, resource gaps, and competing priorities that may impact delivery.

• Develop and maintain project artifacts including integrated plans, milestone trackers, decision logs, status reports, and executive-ready updates.

• Monitor program health and performance, communicate progress to stakeholders at all levels, and lead structured health checks to keep initiatives on track.

• Support product development and launch readiness efforts by aligning cross-functional deliverables, operational handoffs, and implementation planning.

• Drive continuous improvement in project delivery practices, team coordination, communication cadence, and launch execution.

• Build strong working relationships across the organization through credibility, responsiveness, sound judgment, and a solutions-oriented approach.  

Required Qualifications

• Bachelor’s degree in healthcare, life sciences, business, information systems, or a related field, or equivalent combination of education and experience.

• 8+ years of direct experience in a project/program management, product management, SaaS, implementation, or related roles, including significant experience leading complex cross-functional initiatives within healthcare industry.

• Proven ability to influence cross-functional stakeholders, drive alignment, and deliver results in environments with competing priorities and ambiguity.

• Proficiency in Microsoft Office Suite including Project, Word, Excel, Outlook, and PowerPoint.

• Ability to travel up to 20%.

Preferred Qualifications

• Formal project management training or PMP certification.

• Prior experience in Agile or hybrid methodologies

• Lean Six Sigma, or similar, training or certification.

• Experience documenting processes.

• Familiarity with health information systems and related platforms, such as EHR, LIMS, LIS, or other laboratory/clinical systems.

• Working knowledge of applicable regulatory and quality frameworks (e.g., CLIA, CAP, GMP, GCP, IVDR, HIPAA), related design control/validation expectations, and how they impact day-to-day operations and deliverables.

Physical Demands

• Majority of work is performed in a desk/cubicle environment.

• Must possess ability to sit and/or stand for long periods of time.

• Must possess ability to perform repetitive motion.

Training

• All job specific, safety, and compliance training are assigned based on the job functions associated with this employee.

Other

• This position may require periodic travel and some evenings, weekends and/or holidays.

Conditions of Employment:  Individual must successfully complete pre-employment process, which includes criminal background check, drug screening, credit check ( applicable for certain positions) and reference verification.

This job description reflects management’s assignment of essential functions. Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

Caris Life Sciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender, gender identity, sexual orientation, age, status as a protected veteran, among other things, or status as a qualified individual with disability.