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Job Function:
Discovery & Pre-Clinical/Clinical DevelopmentJob Sub Function:
Biotherapeutics R&DJob Category:
Scientific/TechnologyAll Job Posting Locations:
Malvern, Pennsylvania, United States of America, Spring House, Pennsylvania, United States of AmericaJob Description:
About Innovative MedicineOur expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Learn more at https://www.jnj.com/innovative-medicine
We are searching for the best talent for a Senior Principal Scientist, Biologics Discovery Process Research (BDPR) Integrator to be located in Spring House, PA or Malvern, PA.
Purpose: The Senior Principal Scientist, will serve as the scientific and strategic connection point between Therapeutic Development & Supply (TDS) and Discovery teams, enabling seamless end‑to‑end decision‑making for biologics programs. This role is deeply technical and focuses on proactively identifying and mitigating development risks during the discovery phase. The leader will ensure that structural, biophysical, expression, and developability insights are assessed and effectively integrated into Chemistry, Manufacturing and Controls (CMC) strategies and program planning. Additionally, the leader will be tasked with identifying early opportunities to assess knowledge gaps to derisk program development.
The preferred candidate brings deep scientific expertise in protein structure and developability, strong understanding of CMC development requirements, and a proven ability to influence without authority while navigating complex cross‑functional environments.
- Serving as the BDPR integrator on Discovery project teams, aligning strategy, data expectations, and technical risk assessment across Discovery and Development.
- Providing deep scientific guidance on molecule selection, engineering, developability, manufacturability, expression, and protein structure–function considerations.
- Identifying and mitigating CMC, technical, operational, and manufacturability risks early, translating findings into clear program recommendations and mitigation plans.
- Ensuring continuity of scientific rationale and technical context as programs advance from Discovery through candidate nomination and IND‑enabling activities.
- Building trusted cross‑functional partnerships and influencing decision‑making across Therapeutics Discovery (TD), Preclinical Sciences & Translational Safety (PSTS), Therapeutic Areas (TAs), and TDS in matrixed governance and technical forums.
Education:
- PhD in Structural Biology, Biochemistry, Biophysics Chemical or Biomedical Engineering, or a closely related field is required.
Required:
- A minimum of 10 years of biopharmaceutical R&D experience spanning both Discovery and Development / CMC functions.
- Deep technical expertise in at least one of the following areas: protein structure, developability principles, and expression considerations and the impact these have on CMC development.
- Strong understanding of end‑to‑end biologics development, including the scientific and operational needs of CMC.
- Proven ability to influence without authority, manage complex partner groups, and deliver results in a matrixed organization.
- Excellent communication, interpersonal, and scientific storytelling skills.
- Experience supporting IND‑enabling or early clinical development efforts.
- Familiarity with predictive modeling, sequence/structure analysis tools, or computational developability platforms.
- Experience working across global teams or in high‑complexity program environments.
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers, internal employees contact AskGS to be directed to your accommodation resource.
If you are under 18 years of age, you (the candidate) may need to obtain the necessary working papers or other documentation required by state law to start the assignment, as well as get a parent’s consent for the background check.
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Required Skills:
Preferred Skills:
Analytical Reasoning, Biochemistry, Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Collaboration, Data Synthesis, Drug Discovery Development, Molecular Diagnostics, Pharmacovigilance, Process Improvements, Productivity Planning, Program Management, Scientific Research, Tactical Planning, Technical CredibilitySkills Required
- PhD in Structural Biology, Biochemistry, Biophysics, Chemical Engineering, Biomedical Engineering, or a closely related field
- Minimum 10 years of biopharmaceutical R&D experience spanning Discovery and Development or CMC functions
- Deep technical expertise in protein structure, developability principles, or expression considerations and their impact on CMC development
- Strong understanding of end-to-end biologics development and the scientific and operational needs of CMC
- Ability to influence without authority, manage complex partner groups, and deliver results in a matrixed organization
- Excellent communication, interpersonal, and scientific storytelling skills
- Experience supporting IND-enabling or early clinical development efforts
- Familiarity with predictive modeling, sequence or structure analysis tools, or computational developability platforms
- Experience working across global teams or in high-complexity program environments
Johnson & Johnson Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Johnson & Johnson and has not been reviewed or approved by Johnson & Johnson.
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Healthcare Strength — Healthcare coverage is characterized as comprehensive across medical, dental, and vision, with added supports like onsite clinics, fitness centers, and Employee Assistance resources. Mental-health services and wellbeing reimbursements are also described as meaningful components of the overall package.
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Retirement Support — Retirement offerings are portrayed as a major differentiator, combining a 401(k) with employer matching and an employer-funded pension plan. Stock options and other long-term financial supports are also positioned as part of the broader rewards mix.
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Parental & Family Support — Family-related benefits are presented as notably strong, including paid parental leave for all new parents and additional leave types for caregiving and bereavement. Financial assistance for adoption, fertility treatment, and surrogacy is highlighted as a significant support.
Johnson & Johnson Insights
What We Do
Profound Change Requires Boldness. Johnson & Johnson is the largest and most broadly based healthcare company in the world. We’re producing life-changing breakthroughs every day, and have been for the last 130 years. The combination of new technologies and your expertise enables amazing things to happen. Teams from J&J’s consumer business are creating digital tools to help people track the health of their skin. Those working in medical devices are 3-D printing artificial joints personalized for each patient, while researchers in pharmaceuticals use AI to discover lifesaving drugs. Imagine what the rest of our team of 134,000 people at 260 companies in more than 60 countries across the world is accomplishing. We redefine what it means to be a big company in today’s world. Social Media Community Guidelines: http://www.jnj.com/social-media-community-guidelines
