Senior Manager, Supply Chain Planning

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Position Summary
Owns global API supply evolving into DP and FG planning to ensure continuity of supply across external manufacturing. Builds supply plans aligned to demand, capacity, lead times, yields, and inventory targets and maintains disciplined governance for assumptions, parameters, and auditability. Leads constraint management and scenario modelling to support timely decision-making and escalation. Coordinates execution with Manufacturing / CMOs, Sourcing, Quality, CMC / MSAT, and Logistics to mitigate risks and protect downstream supply. Drives continuous improvement in planning accuracy, master data quality, and performance metrics.
 

Key Responsibilities

API Supply Planning & Governance

• Develop and maintain API supply evolving into DP and FG plans together with inventory targets, own planning cadence, assumptions, and parameter governance
• Maintain master data accuracy and plan traceability (lead times, yields, batch sizes, safety stocks)
• Produce deliverables such as API supply plans, parameter governance logs, and inventory targets / reviews
   

Constraints, Scenarios & Risk Escalation

• Lead constraint identification and scenario analysis, recommend mitigations and trade-offs with timelines
• Escalate supply risks with options and coordinate recovery actions with CMOs and internal stakeholders
• Produce deliverables such as constraint dashboards, scenario packs, and recovery action trackers
   

Continuous Improvement

• Track planning KPIs and drive improvements in planning processes and data quality
• Identify recurring sources of variability and coordinate corrective actions with partners
• Produce deliverables such as KPI packs and recurring-issue RCAs / action plans
   

Required Qualifications

• BS+ (Supply Chain, Business, Engineering, or related)
• 7–10 years manufacturing supply planning (API / chemical / pharma experience strongly relevant)
• Strong ERP / MRP / APS capability and analytical problem-solving
   

Preferred Qualifications

• Experience with external manufacturing governance and long lead-time materials
• Experience in pharmaceutical / biotech supply planning environments (preferred)
   

Key Competencies

• API supply planning, inventory optimization, and parameter governance, plan traceability, and auditability discipline
• Constraint management, scenario modelling, and mitigation planning, trade-off communication, and escalation timing
• Partner governance and performance coordination across CMOs and internal stakeholders, recovery execution follow-through
• Cross-functional leadership, escalation, and executive-ready risk / decision communication
• Systems / data fluency (ERP / MRP / APS), KPI tracking, and continuous improvement of planning accuracy

We are committed to fostering an inclusive and diverse workplace and do not discriminate on the basis of any legally protected characteristics. Madrigal processes your personal data in connection with its recruitment and talent sourcing activities in accordance with applicable data protection laws. Further information about how your personal data is processed, together with details of your rights and how to exercise them, is available in our Job Applicant Privacy Notice, which is made available to you if you apply through Workday.

Please note that this job description is not exhaustive and may evolve over time. Only shortlisted candidates will be contacted. Applicants must be authorized to work in the country of employment at the time of application. Employment terms, where applicable, will be governed by relevant collective bargaining agreements.

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.