Jobs at Madrigal Pharmaceuticals

Provide high-level administrative and operational support to the EVP, Technical Operations and leadership team. Manage complex executive calendars, travel, expenses, leadership meetings, cross-functional projects, and confidential information. Act as trusted liaison, enabling operational execution, mentoring administrative staff, and supporting continuity in a fast-paced biotech environment.

Lead global supply chain operational excellence and digital enablement to standardize SOPs, run a continuous improvement pipeline, automate workflows, and build KPI routines. Partner with IT/Analytics to deliver dashboards, training, and adoption tracking, ensure sustainment through controls, and drive capability building in structured problem solving across global teams.

Serve as FP&A strategic partner to Tech Ops (CMC, Supply Chain, QA), managing budgeting, forecasting, month-end close, executive reporting, and financial analysis to support manufacturing, supply, and technical operations decisions.

Manage daily 3PL operations, ensure compliance, coordinate order fulfillment, monitor service performance, and drive continuous improvement for logistics.

Execute GMP batch disposition and release for APIs and intermediates by reviewing batch records, CofAs, and release packages against approved specifications. Coordinate resolution of deviations, OOS/OOT investigations, and documentation gaps with CMOs/CDMOs. Maintain inspection-ready release records in Veeva, track release metrics, drive right-first-time improvements, support change controls, and partner with MSAT, Supply Chain, and Regulatory to ensure supply continuity.

The Associate Director, Marketing KOL Engagement will lead healthcare professional engagement initiatives, manage speaker bureau programs, and develop peer-to-peer educational strategies to enhance brand adoption and advocacy for Rezdiffra.

The Director, Global Publications Lead manages scientific publications for Madrigal, ensuring alignment with medical affairs strategies, compliance, and impactful communication with stakeholders.

Serve as the technical lead for enterprise finance systems, administering and optimizing NetSuite, Coupa, Concur, and Workiva. Drive finance technology implementations, automation, reporting improvements, and SOX-compliant controls. Liaise between Finance, IT, vendors, and global stakeholders to manage upgrades, reconciliations, documentation, training, and audit support.

Provide site-facing MSAT leadership and technical oversight for assigned API CMO(s). Monitor performance, coordinate investigations and CAPAs, lead transfer and change readiness, assess technical risk, drive partner improvements, and maintain inspection-ready documentation and knowledge management.

The Executive Director, Strategic Projects will drive commercial strategy execution and cross-functional collaboration within Madrigal, ensuring operational excellence and leading high-priority initiatives.

Lead and mature the global Pharmacovigilance Quality function, ensuring compliance and efficient operations, while mentoring a global team.

The role involves overseeing GCP quality assurance activities for clinical trials, ensuring compliance with regulations and industry standards, managing vendor quality, and leading quality events and process improvements.

The Senior Director, Legal and Compliance Operations ensures effective implementation of compliance initiatives, policy governance, and operational excellence in compliance practices, while collaborating closely with various functional teams to support business objectives and maintain a culture of integrity.

Lead QMS process design and operational excellence for a biopharmaceutical company, ensuring compliance, efficiency, and continuous improvement from development to commercial operations.

Lead ADME strategy and execution for nonclinical and clinical programs. Design, oversee, and interpret in vitro and in vivo ADME studies, manage CROs, perform DDI risk assessment and PBPK modeling, integrate PK data to inform development, and author ADME regulatory sections supporting submissions and interactions.

The Senior Biostatistician will perform statistical modeling and analyses, design clinical trials, and collaborate with cross-functional teams to support R&D objectives in biopharmaceuticals.

Field-based access and reimbursement manager supporting HCPs to secure patient access to a specialty pharmacy product. Responsibilities include benefits investigations, prior authorizations, appeals, payer and SP collaboration, provider education and training, data-driven trend analysis, escalation of unresolved issues, and cross-functional coordination with market access, sales, and patient support teams. Frequent travel within the territory required.

The Senior Manager Consumer Marketing develops and executes marketing programs for MASH patients, oversees content development, and collaborates with cross-functional teams to ensure accuracy and compliance, thereby contributing to the commercial success of resmetirom.

Lead strategic sourcing and category management for CMC, Supply Chain, and Quality. Develop sourcing strategies, manage supplier relationships, run RFx processes, negotiate contracts, mitigate supply risk, ensure GxP compliance, and deliver cost and performance improvements while partnering cross-functionally to support clinical and commercial programs.

Lead and govern batch review and disposition for commercial API and intermediates, with DP cross-coverage. Own batch disposition standards, Veeva batch disposition process, cycle-time and backlog performance, deviation resolution with CMOs/CDMOs, inspection-ready documentation, and mentor batch release staff. Partner with MSAT, Supply Chain, and Regulatory to ensure supply continuity and support health authority inspections.