Senior Manager, Lead Executive Assistant

Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating nuzafatide pevedotin (formerly 5528), a Bicycle® Drug Conjugate (BDC®) targeting EphA2, a historically undruggable target; zelenectide pevedotin (formerly BT8009), a BDC targeting Nectin-4, a well-validated tumor antigen; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radioconjugates (BRC®) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.

Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts, USA. For more information, visit bicycletherapeutics.com

Culture is key and all Bicycle employees actively embrace and role model our company values: 

• We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.   
• We are Dedicated to our Mission. You can’t change the world if you don’t have determination. 
• We are One Team. We only succeed when we work together.  

Your mission is to act as a business partner and force multiplier for the CEO and key members of the Executive Team. You will provide seamless, forward-thinking executive support that anticipates needs and clears the path for our leaders to focus on driving Bicycle’s mission. As a highly experienced EA, you will set the standard for administrative excellence across the company, acting as a key mentor and coordination point for the EA community and driving the function forward through your own world-class performance.

Working Arrangement:

To best support our executive team and act as a key connector for our colleagues, this role requires a regular on-site presence with the CEO and other Executives and will be based on-site in our Cambridge office. Flexibility to travel to London and other sites occasionally may be required.

Your Responsibilities: 
Strategic Executive Partnership:

• Provides comprehensive, proactive administrative and coordination support to the CEO and other executives. You will be responsible for expertly managing their schedule to ensure their time is protected and optimised according to business priorities set with the Chief of Staff.
• Expertly manage and triage complex, fluid calendars for the CEO, Chief Corporate Development Officer (CCDO), Chief Legal Officer (CLO), and Chief of Staff, anticipating conflicts and making high-level judgment calls to protect their time.
• Arrange complex international travel, itineraries, and meeting logistics, ensuring every detail is flawlessly executed.
• Prepare agendas, briefing materials, and coordinate presentations for key executive meetings.
• Manage and submit accurate and timely expense reports on behalf of the executives.
• Serve as a key gatekeeper and point of contact for the executive office, handling confidential information with the utmost discretion.

Board & Governance Coordination:

• Lead and manage all coordination for Board of Directors meetings, Committee meetings and related activities, including scheduling, support preparation and distribution of materials, and all logistical arrangements.

Administrative Excellence & Coordination:

• Act as the central point of coordination and collaborative partner for the Executive Assistant team, organising cover for holidays and sickness to ensure continuous, high-quality support for all leaders.
• Serve as a mentor and role model for the EA community, encouraging sharing best practices and improved ways of working, coaching colleagues to elevate the capabilities of the entire function.
• Proactively identify and implement new tools, systems, and processes to improve efficiency and collaboration across the administrative team.
• Independently lead and manage key projects on behalf of the executive office and Chief of Staff.

Operational & Project Support:

• Independently lead and manage key administrative projects on behalf of the executive office and Chief of Staff.
• Provide dedicated operational support to the Legal team, including organising team meetings and assisting with the administration of our Contract Management System (CMS).
• Manage the executive signature process for critical corporate and clinical contract documentation, ensuring timeliness and compliance.
• Provide flexible, ad hoc administrative and project support to the wider executive team and other key functions as business priorities demand.

Who you are: Skills & Competencies: 

Knowledge & Expertise:

• Core Expertise: You are a recognised expert in C-suite executive support, shaping best practices through your own work and influencing the entire administrative function.
• Data / Insight: You provide foresight and strategic interpretation of executive priorities and scheduling conflicts to make informed decisions that optimise the leadership team's time and focus.
• Knowledge Sharing: You act as a catalyst for collaboration within the EA community, actively fostering an environment of shared knowledge, enabling the team to actively identify new tools and processes.

Job Complexity:

• Task / Project Delivery: You oversee a complex portfolio of executive support activities and lead strategic projects on behalf of the Chief of Staff and executive team.
• Problem-Solving: You resolve complex organisational challenges in scheduling and logistics, often anticipating issues before they arise and navigating sensitive situations with diplomacy.
• Strategic Impact: You directly shape the effectiveness of the executive team by ensuring their time is aligned with the company's highest strategic priorities.

Independence:

• Autonomy: You operate with broad independence, setting direction for administrative priorities and reliably making high-level judgment calls on behalf of the executives you support.
• Decision-Making: You make high-impact decisions with long-term implications, such as managing executive commitments and resolving conflicting priorities.
• Leadership / Mentorship: You act as a senior mentor and coach for the EA community, raising the bar for the entire function through your expertise and guidance.

Values & Behaviours:

• One Team: You act as a role model for teamwork, building strong collaborative partnerships and creating an inclusive, supportive environment for the entire EA community.
• Adventurous: You champion positive change by introducing new ways of working and innovative technologies that improve the efficiency and impact of the administrative function.
• Dedicated to our Mission: You demonstrate persistence and resilience in a fast-paced, high-pressure environment, and you motivate others by connecting administrative excellence to our core mission.

• A proven track record of providing executive-level support to C-suite leaders in a fast-paced, dynamic environment.
• Experience within the BioTech, BioPharma, or life sciences industry is essential, providing a strong understanding of the scientific environment and the context for key meetings and stakeholders.
• Exceptional organisational and project management skills, with the ability to manage complex scheduling, international travel, and high-stakes meetings (e.g., Board of Directors) flawlessly.
• The ability to act as a true business partner, with a forward-thinking mindset that anticipates needs and proactively solves problems.
• A natural collaborator and mentor with a passion for helping others develop and raising the standard of an administrative function.
• Unquestionable discretion and experience handling highly confidential and sensitive information.

• State-of-the-art campus environment with on campus restaurant and Montessori nursery
• Flexible working environment
• Competitive reward including annual company bonus 
• Employee recognition schemes
• 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
• Employer contribution to pension (employee does not have to contribute) 
• Life assurance cover 4x basic salary 
• Private Medical Insurance, including optical and dental cover 
• Enhanced parental leave policies
• Group income protection
• Employee assistance program
• Health Cash Plan
• Access to company subsidized gym membership
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc. 
• Cycle to work scheme 

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.