Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes. Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, agitation associated with dementia due to Alzheimer’s disease, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, as well as multiple novel product candidates addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States. Together, we are on a mission to solve some of the brain’s biggest problems so patients and their loved ones can flourish. For more information, please visit us at www.axsome.com and follow us on LinkedIn and X.
About This Role
Axsome Therapeutics is seeking a Senior Manager, Finance who will be responsible for the preparation of Axsome's external financial reporting, including its periodic SEC filings, the research and documentation of technical accounting matters affecting the Company's financial statements, supporting the design, improvement, and testing of internal controls under SOX 404 for areas under responsibility. The Senior Manager, Finance will play a central role in the quarterly and annual external reporting cycle, working with colleagues in finance and throughout the organization in the preparation of financial statements, including drafting, reviewing, and improving the quality of information provided to readers and stakeholders. The Senior Manager, Finance will be a trusted business partner across finance, legal, investor relations, and Axsome's internal and external audit partners. This role will report directly to the Senior Director, Finance.
This role is based at Axsome’s HQ in New York City with an on-site requirement of at least three days per week. We are unable to consider candidates who are looking for fully remote roles.
Job Responsibilities and Duties include, but are not limited to, the following:
- Prepare Axsome's external financial statements and footnotes, including the statement of cash flows, along with the Management's Discussion and Analysis, supporting schedules for the Forms 10-Q and 10-K, and XBRL review
- Research and draft technical accounting memoranda on non-routine transactions, including share-based compensation awards, debt and equity instruments, business combinations, asset acquisitions, in- and out-licensing arrangements, and collaboration arrangements
- Monitor new accounting pronouncements and SEC rulemaking, assess applicability to Axsome, and prepare documentation and lead implementation
- Support the design, improvement, and testing of internal controls under SOX 404 for areas under responsibility, including control documentation and coordination with the Company’s internal audit service provider and external auditor
- Draft new accounting policies and periodically review and update existing policies
Requirements / Qualifications
- Bachelor's or Master's degree in Accounting, Finance, or a related field; CPA required
- 7+ years of progressive accounting experience, ideally a mix of public accounting and SEC reporting/technical accounting
- Strong working knowledge of U.S. GAAP and SEC reporting requirements
- Experience with SOX 404 compliance at a public company, including the design, documentation, and testing of business process controls
- Experience with financial reporting tools such as DFIN Active Disclosure or Workiva preferred
- Experience in biopharmaceutical or life sciences industry preferred
- Ability to work on site Monday, Tuesday, and Thursday. We are unable to consider candidates who are looking for fully remote roles
Experience, Knowledge and Skills
- Strong technical accounting research skills, with the ability to analyze authoritative guidance and reach and document supportable conclusions
- Excellent oral and written communication skills, with the ability to draft clear technical accounting documentation and articulate conclusions to non-technical audiences
- Demonstrated ability to manage multiple deliverables against fixed external filing deadlines
- Possess a problem-solving mindset with demonstrated "lean-forward" approach and the ability to think critically
- Proficiency with accounting research tools such as Intelligize, Checkpoint, or FASB codifications
- Experience with ERP and financial close systems, such as Microsoft Dynamics 365 Business Central
- Strong planning and organizational skills, attention to detail, execution, and follow-through
Salary & Benefits
The anticipated salary range for this role is $130,000 - $150,000. We encourage candidates of all levels to apply as there may be flexibility on final job title and responsibilities. The salary offer will be based on a variety of factors, including experience, qualifications, internal equity and location. Axsome offers a competitive employment package that includes an annual bonus, significant equity and a generous benefits package.
Axsome is committed to equal employment opportunity and providing reasonable accommodations to applicants with physical and/or mental disabilities. We value and encourage diversity and solicit applications from all qualified applicants without regard to race, color, gender, sex, age, religion, creed, national origin, sexual orientation, gender identity, ancestry, citizenship, marital status, physical or mental disability, medical condition, veteran status, genetic information, or any other characteristic protected by federal, state, or local law.
Axsome Therapeutics does not accept unsolicited resumes from recruiters or third-party recruitment agencies and will not pay placement fees for unsolicited candidates that are sent to hiring managers, the HR team or other Axsome team members. Only approved vendors who have been explicitly asked to support a specific search will receive access to our Applicant Tracking System to submit candidates for consideration.
Skills Required
- Bachelor's or Master's degree in Accounting, Finance, or a related field
- CPA certification
- 7+ years of progressive accounting experience
- Experience in public accounting and SEC reporting or technical accounting
- Strong knowledge of U.S. GAAP and SEC reporting requirements
- Experience with SOX 404 compliance at a public company, including control design, documentation, and testing
- Experience with financial reporting tools such as DFIN Active Disclosure or Workiva
- Experience in the biopharmaceutical or life sciences industry
- Ability to work on site Monday, Tuesday, and Thursday in New York City
- Strong technical accounting research and documentation skills
- Excellent oral and written communication skills
- Ability to manage multiple deliverables against fixed external filing deadlines
- Proficiency with Intelligize, Checkpoint, or FASB codifications
- Experience with ERP and financial close systems such as Microsoft Dynamics 365 Business Central
- Strong planning, organizational, execution, attention-to-detail, and follow-through skills
Axsome Therapeutics, Inc. Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Axsome Therapeutics, Inc. and has not been reviewed or approved by Axsome Therapeutics, Inc..
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Healthcare Strength — Employer contributions cover around 85% of medical, dental, and vision premiums, with multiple plan options (EPO/PPO/HDHP) plus company‑paid life, AD&D, and short‑/long‑term disability. Eligibility typically begins the first of the month after start, supporting comprehensive access.
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Equity Value & Accessibility — New hires commonly receive stock options and RSUs with potential annual grants, alongside an Employee Stock Purchase Plan at a 15% discount. Company materials and postings position equity as a significant component of total rewards.
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Leave & Time Off Breadth — PTO starts at 15 days and increases to 20 with tenure, complemented by 13 company holidays, floating and mental‑health days, sick time, and a five‑week sabbatical at five years. Paid parental leave up to 12 weeks for birthing parents (four weeks for non‑birthing) plus five days of grandparent leave expand family‑friendly time off.
Axsome Therapeutics, Inc. Insights
What We Do
Axsome Therapeutics, Inc. is a biopharmaceutical company developing novel therapies for central nervous system (CNS) conditions that have limited treatment options. Through development of therapeutic options with novel mechanisms of action, we are transforming the approach to treating CNS conditions. At Axsome, we are intensely committed to developing products that meaningfully improve the lives of patients and provide additional therapeutic options for physicians








