Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Let’s do something amazing together! The Sr. Director, Marketing will play a critical role in leading brand strategy and execution for Plozasiran, an siRNA therapy targeting APOC3 for patients with Familial Chylomicronemia Syndrome (FCS) and Severe Hypertriglyceridemia (sHTG). This is a high-visibility leadership role responsible for shaping marketing strategy, building a high-performing team, and driving cross-functional alignment to ensure launch success. Over time, the scope may expand to include additional cardiometabolic indications and pipeline products, including Zodasiran.
Patients are counting on us to deliver with speed and excellence. This role offers the opportunity to shape the commercial future of a first-in-class therapy and make a direct impact on patients living with serious, underserved lipid disorders.
This role is based in Pasadena, California, with an expectation to be in the office five days a week.
Responsibilities
- Lead brand planning, including situation analysis, competitive landscape assessment, strategic priorities, and tactical launch plans.
- Drive product positioning, campaign development, and message development across HCP and patient audiences.
- Develop and implement market development tactics that build awareness of unmet need among key customer segments.
- Design and execute integrated marketing campaigns across HCP promotion, patient marketing, digital, and online media.
- Lead omnichannel campaigns, microtargeting, and next-best-action programs to optimize customer engagement.
- Support planning and execution of national sales meetings.
- Work with Business Analytics to generate market insights and optimize customer communication against launch objectives.
- Manage creative, agency of record, media, digital, and peer-to-peer agency partners.
- Oversee project timelines and budgets; participate in monthly budget forecasting; ensure spend aligns with annual plan.
- Partner with Market Access to advance Arrowhead's patient support services program.
Requirements
- Bachelor's degree required
- 12+ years of pharmaceutical or biotech marketing experience, with 5 years of experience in a leadership role
- Direct product launch experience required
- Demonstrated success building and leading marketing teams in a matrixed organization.
- Strong track record partnering with Medical Affairs, Market Access, and Sales on integrated launch execution
- Demonstrated executive presence with the ability to influence senior leadership, present confidently to executive-level audiences, and represent the brand credibly with external stakeholders including KOLs and industry partners
- Experience managing external agencies and marketing budgets
- Demonstrated ability to coordinate, prioritize and handle multiple priorities and projects simultaneously with keen attention to detail
- Must be comfortable managing multiple competing, frequently shifting priorities, and working through uncertainty
- Minimum travel requirements of 25% of the time
Preferred
- MBA or advanced degree preferred.
- Rare disease, cardiometabolic, or lipid-disorder therapeutic experience strongly preferred
- Experience in cardiometabolic therapeutic area, preferably with a focus on dyslipidemias
- Experience in a smaller, rapidly growing, company
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
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Skills Required
- Bachelor's degree
- 12+ years of pharmaceutical or biotech marketing experience
- 5 years of experience in a leadership role
- Direct product launch experience
- Demonstrated success building and leading marketing teams in a matrixed organization
- Strong track record partnering with Medical Affairs, Market Access, and Sales on integrated launch execution
- Demonstrated executive presence and ability to influence senior leadership and external stakeholders
- Experience managing external agencies and marketing budgets
- Ability to coordinate, prioritize, and handle multiple priorities and projects with keen attention to detail
- Comfortable managing multiple competing, frequently shifting priorities and working through uncertainty
- Minimum travel requirements of 25% of the time
- Current, valid authorization to work in the country where the role is located
- MBA or advanced degree
- Rare disease, cardiometabolic, or lipid-disorder therapeutic experience (strongly preferred)
- Experience in cardiometabolic therapeutic area, preferably dyslipidemias
- Experience in a smaller, rapidly growing company
What We Do
Arrowhead Pharmaceuticals is a clinical stage, Nasdaq listed (ticker ARWR) company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, our therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Our RNAi-based therapeutics are at the leading edge of genetic-based therapy with the potential to bring life changing treatments for patients. Our Targeted RNAi Molecule (TRiMTM) platform utilizes ligand-mediated delivery and is designed to enable tissue-specific targeting while being structurally simple. The TRiM platform builds on more than a decade of work on actively targeted drug delivery and offers several advantages including simplified manufacturing and reduced costs; multiple routes of administration; and potential for improved safety. Our employees are nimble, science-driven, and innovative professionals. A career at Arrowhead offers the opportunity to collaborate with top notch scientists to rapidly discover and develop RNAi-based therapeutics to add to our growing pipeline. Research and development activities are located in Madison, WI. Our R&D group includes fully-integrated capabilities for chemistry, biology, and toxicology. Madison is an exciting and sophisticated city that includes state government, the flagship campus of the University of Wisconsin, and major research organizations. Our HQ, clinical and regulatory operations are located in Pasadena, CA. Just north of Los Angeles and resting in the foothills of the San Gabriel Mountains, Pasadena is known for its natural scenic beauty, vibrant cultural and academic environment and rich architectural setting.
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