Senior Director, Global HR Operations and Systems

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Department: Human Resources

Reports To: VP, Total Rewards & HR Operations

Job Type: Full-Time

Location: Waltham, MA or Conshohocken, PA (3 days per week in office)

Madrigal Pharmaceuticals, a rapidly growing life sciences company committed to innovation and improving patient outcomes, is seeking a Senior Director, HR Operations and Systems to shape and scale our people operations globally. This high-impact role will serve as a strategic thought partner across the business, with a dual focus on enhancing the employee experience and building a scalable foundation for the future of work.
You will lead the design and delivery of global HR operational excellence, data insights, and employee-facing processes leveraging our systems (primarily Workday). The ideal candidate brings a consultative, business-minded approach to HR, understands the unique dynamics of a scaling biotech or life sciences environment, and is energized by the opportunity to shape culture and capability through data and design.

• Partner closely with HR, business, and functional leaders to understand evolving business needs and co-create scalable, people-first solutions.
• Anticipate future operational requirements and build frameworks that support a high-growth, global organization.

• Lead the global HR Operations team, ensuring service delivery excellence across regions and functions.
• Build and optimize global processes across the employee journey.
• Ensure consistent, compliant, and culturally relevant HR practices in the U.S. and international markets.
• Establish a robust governance structure for employee data integrity and process adherence.

• Champion a human-centered approach to employee services and touchpoints that drive engagement and simplicity.
• Streamline HR service delivery by leveraging automation and integrated technology.
• Develop global knowledge bases, self-service portals, and process improvements to reduce friction and increase employee satisfaction.

• Lead the development of real-time dashboards and people analytics tools to monitor and drive key metrics.
• Translate complex data into actionable insights that enable smarter decision-making for executives and business partners.
• Advance predictive analytics capabilities and elevate HR’s role as a strategic driver of business outcomes.

• Build HR operational models and systems that scale with the company’s growth trajectory and evolving workforce needs.
• Ensure systems and tools are forward-looking, adaptable, and equipped to support a rapidly changing business landscape.
• Serve as a key Workday leader, ensuring optimization, integrations, and functionality are aligned with future enterprise goals.

• Bachelor’s degree in Human Resources, Business, Data Analytics, or related field; advanced degree preferred.
• 15+ years of progressive HR experience, with at least 5 years leading HR operations in a life sciences or biotech company.
• Proven leadership in implementing and managing Workday globally as the HR system of record.
• Experience supporting international operations and designing globally scalable solutions.

• Strategic thinker with a consultative mindset and strong business acumen.
• Exceptional ability to synthesize insights from data and communicate with impact to diverse stakeholders.
• Skilled in change management, process design, and cross-functional collaboration.
• High emotional intelligence and credibility in advising senior leaders.

Compensation: Base salary is determined by several factors that include, but are not limited to, a successful candidate's qualifications, skills, education, experience, business needs, and market demands. The role may also be eligible for bonus, equity, and comprehensive benefits, which include flexible paid time off (PTO), medical, dental, vision, and life and disability insurance.

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.

Please be aware that we are currently receiving numerous reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Interviews with Madrigal are conducted via the Zoom platform.

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for Madrigal we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks.