Senior Director, Global HR Operations and Systems

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Senior Director, Global HR Operation and Systems

Department: Human Resources

Reports To: VP, Total Rewards & HR Operations

Job Type: Full-Time

Location: Waltham, MA or Conshohocken, PA (3 days per week in office)

Position Summary

Madrigal Pharmaceuticals, a rapidly growing life sciences company committed to innovation and improving patient outcomes, is seeking a Senior Director, HR Operations and Systems to shape and scale our people operations globally. This high-impact role will serve as a strategic thought partner across the business, with a dual focus on enhancing the employee experience and building a scalable foundation for the future of work.
You will lead the design and delivery of global HR operational excellence, data insights, and employee-facing processes leveraging our systems (primarily Workday). The ideal candidate brings a consultative, business-minded approach to HR, understands the unique dynamics of a scaling biotech or life sciences environment, and is energized by the opportunity to shape culture and capability through data and design.

Key Responsibilities

Strategic Business Partnership & Planning

• Partner closely with HR, business, and functional leaders to understand evolving business needs and co-create scalable, people-first solutions.

• Anticipate future operational requirements and build frameworks that support a high-growth, global organization.

Global HR Operations Leadership

• Lead the global HR Operations team, ensuring service delivery excellence across regions and functions.

• Build and optimize global processes across the employee journey.

• Ensure consistent, compliant, and culturally relevant HR practices in the U.S. and international markets.

• Establish a robust governance structure for employee data integrity and process adherence.

Employee Experience & Process Design

• Champion a human-centered approach to employee services and touchpoints that drive engagement and simplicity.

• Streamline HR service delivery by leveraging automation and integrated technology.

• Develop global knowledge bases, self-service portals, and process improvements to reduce friction and increase employee satisfaction.

Data Analytics, Reporting & Insights

• Lead the development of real-time dashboards and people analytics tools to monitor and drive key metrics.

• Translate complex data into actionable insights that enable smarter decision-making for executives and business partners.

• Advance predictive analytics capabilities and elevate HR’s role as a strategic driver of business outcomes.

Future-Ready Infrastructure

• Build HR operational models and systems that scale with the company’s growth trajectory and evolving workforce needs.

• Ensure systems and tools are forward-looking, adaptable, and equipped to support a rapidly changing business landscape.

• Serve as a key Workday leader, ensuring optimization, integrations, and functionality are aligned with future enterprise goals.

Qualifications

Education & Experience

• Bachelors degree preferred or equivalent work experience

• 15+ years of progressive HR experience, with at least 5 years leading HR operations in a life sciences or biotech company.

• Proven leadership in implementing and managing Workday globally as the HR system of record.

• Experience supporting international operations and designing globally scalable solutions.

Core Competencies

• Strategic thinker with a consultative mindset and strong business acumen.

• Exceptional ability to synthesize insights from data and communicate with impact to diverse stakeholders.

• Skilled in change management, process design, and cross-functional collaboration.

• High emotional intelligence and credibility in advising senior leaders.

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. The base salary range for this position is $234,000 - $286,000 per year.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.  

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. 

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected]. 

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. 

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. 

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. 

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.  

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected].