Passionate about precision medicine and advancing the healthcare industry?
Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.
Responsibilities:
Collaborate with cross-functional teams including medical oncologists, research scientists, and engineers to develop and maintain clinical data models.
Translate customer needs and product requests into key concept definitions and business logic for complex models.
Facilitate integration of data model into workflows, applications, and data deliveries.
Structure and normalize data from a variety of sources, including Tempus curated data, EHR integrations, and lab systems.
Develop and maintain knowledge bases for clinical concepts.
Create and execute validation plans in conjunction with SMEs for new models and disease types.
Proactively monitor and support quality assurance and process improvement initiatives.
Monitor performance of production processes and recommend areas for improvement.
Qualifications:
5+ years of oncology data modeling experience.
Experience working with real world data from various sources (e.g., curation workflows, EHRs, lab systems, claims, research datasets).
Experience working with modern ELT tools such as DBT to maintain high volume, high velocity data warehouses
Experience working with standard medical terminologies (e.g., SNOMED CT, RxNorm, LOINC, ICD-9/10).
Nice-to-haves:
Clinical background (MD/DO, PharmD, PA, NP, RN, etc.).
Familiarity with next-generation sequencing data.
Experience with real world data analysis in Python or R.
Participation in professional organizations (e.g., OHDSI, AMIA).
We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Skills Required
- 5+ years of oncology data modeling experience
- Experience working with real world data from various sources
- Experience working with modern ELT tools such as DBT
- Experience working with standard medical terminologies
Tempus AI Compensation & Benefits Highlights
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Healthcare Strength — Healthcare coverage spans medical, dental, vision, life/AD&D, short‑term disability, mental‑health/EAP, FSAs, and even pet insurance. Feedback suggests this breadth meets core needs for many employees.
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Wellbeing & Lifestyle Benefits — On‑site cafeteria meals, stocked snacks, an on‑site barista, commuter benefits, gym discounts, ERGs, and regular events enhance daily experience, especially at Chicago HQ. Feedback suggests these amenities add tangible value for those working regularly on‑site.
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Parental & Family Support — Parental leave and an onsite Mother’s Room are highlighted, alongside hybrid work in many roles. Feedback suggests these supports help work‑life integration for caregivers.
Tempus AI Insights
What We Do
We bring together one of the world’s largest libraries of multimodal clinical and molecular data with a robust suite of AI tools to help physicians personalize care in real time, connect patients with therapies and clinical trials, and enable partners to accelerate discovery and development of new treatments. With ~8 million de-identified research records and 350+ petabytes of data, Tempus partners with more than half of U.S. oncologists and the majority of the top 20 global pharma companies. Our teams are pioneering work across oncology, neurology, psychiatry, cardiology, and beyond—transforming how care is delivered and therapies are developed. At Tempus, every role contributes to our mission: to help each patient benefit from the experiences of those who came before. For more information, visit tempus.com.
Why Work With Us
We’re looking for people who can change the world. People who question the status quo and refuse to shy away from tough problems. For builders who are never done building, and the learners who are never done learning. Passionate individuals with undying curiosity who want to take on one of the greatest challenges humanity has ever faced—head on.
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Tempus AI Offices
Hybrid Workspace
Employees engage in a combination of remote and on-site work.
Most of the team follows a hybrid policy, with some roles allowing for a fully remote arrangement and some roles being onsite only.






























