Senior Computational Biologist I

Posted 5 Hours Ago
Be an Early Applicant
New York City, NY, USA
Hybrid
100K-175K Annually
Senior level
Artificial Intelligence • Big Data • Healthtech • Machine Learning • Analytics • Biotech • Generative AI
Tempus is a technology company leading the adoption of AI to advance precision medicine and patient care.
The Role
Partner with pharmaceutical clients to design and execute computational research using multimodal clinical and genomic data. Analyze transcriptomic, molecular, clinical trial, and real-world evidence datasets; develop integrative models; and deliver actionable insights for drug R&D. Lead client interactions, collaborate with Research, Engineering, Data Science, Product, and Sales teams, improve computational workflows, communicate technical findings, and author scientific publications demonstrating AI and multimodal analysis applications.
Summary Generated by Built In

Passionate about precision medicine and advancing the healthcare industry?

Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.

Responsibilities:
Partner with our pharma clients to design, develop and execute computational research leveraging the Tempus platform to advance drug R&D programs.
Become an expert in Tempus multimodal clinical and genomic data.
Analyze and integrate large, diverse clinical and molecular datasets to extract insights and drive new research opportunities.
Lead scientific and technical interactions with clients to co-architect solutions and projects.
Become an expert in current and prospective clients’ strategies, pipelines, and portfolios to identify where the Tempus platform can add value and collaborate with sales teams to realize that value.
Collaborate with Research, Engineering & Data Science teams to develop and deliver innovative computational solutions.
Drive continual improvement of the Tempus platform by communicating client feedback, staying ahead of research and industry trends, championing opportunities for new markets, and influencing our leadership and global account strategy teams.
Work with Product and Engineering teams to streamline the workflow of computational analyses.
Document, summarize, and communicate highly technical results and methods clearly to non-technical audiences.
Author whitepapers and peer-reviewed manuscripts illustrating the value of multimodal analysis and AI in drug discovery
Qualifications:
Education to Masters or Ph.D. level combining
quantitative and/or computational skills, e.g., Computational Biology, Biostatistics/Statistical Genetics, Bioinformatics, Biomedical Informatics, Biometrics, Data Science for Health, or similar.
biological or medical knowledge, e.g. Human Disease, Genetics/Genomics, Molecular Biology, or Immunology
Comfort in a client-facing role
Proficient in R or Python
Strong understanding of the molecular nature of human disease
Expert in delivering actionable insight from transcriptomic data sets.
Experience with Clinical Trial Data and/or Real World Evidence
Experience with integrative methods to model multi-modal clinical and/or omics data.
Experienced in SQL
Thrive in a fast-paced environment and willing to shift priorities seamlessly.
Experience in any of the following will also be beneficial: drug R&D; oncology; immunology; single cell or spatial transcriptomics; mechanistic modeling and inference; knowledge and graph-based AI techniques

CHI: $100,000-$160,000
NYC/SF: $115,000-$175,000


The expected salary range may vary for other locations. Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.

We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. 

Skills Required

  • Master’s or Ph.D. degree in Computational Biology, Biostatistics, Statistical Genetics, Bioinformatics, Biomedical Informatics, Biometrics, Data Science for Health, or a related field
  • Biological or medical knowledge, including human disease, genetics/genomics, molecular biology, or immunology
  • Comfort working in a client-facing role
  • Proficiency in R or Python
  • Strong understanding of the molecular nature of human disease
  • Expertise delivering actionable insights from transcriptomic datasets
  • Experience with clinical trial data and/or real-world evidence
  • Experience with integrative methods for modeling multimodal clinical and/or omics data
  • Experience with SQL
  • Ability to thrive in a fast-paced environment and shift priorities seamlessly
  • Experience in drug research and development
  • Experience in oncology
  • Experience in immunology
  • Experience with single-cell or spatial transcriptomics
  • Experience with mechanistic modeling and inference
  • Knowledge of graph-based AI techniques

What the Team is Saying

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Tempus AI Compensation & Benefits Highlights

  • Healthcare Strength Health coverage is described as comprehensive, including medical, dental, vision, life and disability insurance, plus mental‑health resources and HSA/FSA options, with core items employer‑verified in mid‑2026.
  • Leave & Time Off Breadth Paid time off and parental leave are consistently part of the package, with parental leave commonly cited around three months and related pages noted as recently employer‑verified.
  • Wellbeing & Lifestyle Benefits Everyday perks such as commuter benefits, on‑site meals and coffee programs, gym discounts, charitable matching, ERGs, pet insurance, and team events are widely highlighted, with some amenities available in select offices.

Tempus AI Insights

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The Company
HQ: Chicago, IL
3,775 Employees
Year Founded: 2015

What We Do

We bring together one of the world’s largest libraries of multimodal clinical and molecular data with a robust suite of AI tools to help physicians personalize care in real time, connect patients with therapies and clinical trials, and enable partners to accelerate discovery and development of new treatments. With ~8 million de-identified research records and 350+ petabytes of data, Tempus partners with more than half of U.S. oncologists and the majority of the top 20 global pharma companies. Our teams are pioneering work across oncology, neurology, psychiatry, cardiology, and beyond—transforming how care is delivered and therapies are developed. At Tempus, every role contributes to our mission: to help each patient benefit from the experiences of those who came before. For more information, visit tempus.com.

Why Work With Us

We’re looking for people who can change the world. People who question the status quo and refuse to shy away from tough problems. For builders who are never done building, and the learners who are never done learning. Passionate individuals with undying curiosity who want to take on one of the greatest challenges humanity has ever faced—head on.

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Tempus AI Offices

Hybrid Workspace

Employees engage in a combination of remote and on-site work.

Most of the team follows a hybrid policy, with some roles allowing for a fully remote arrangement and some roles being onsite only.

Typical time on-site: 3 days a week
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