Senior Clinical Trial Manager (Sr CTM)
You’ve run trials well — now run more of them, and help others do the same. You’ll manage a portfolio of trials or a full region, own vendor strategy end-to-end, and become the person other CTMs turn to when something’s stuck.
Position Description
This individual manages clinical regions and/or multiple trials simultaneously, with broad involvement in work central to Nurix’s strategic goals, and plays a key role in developing junior clinical operations staff.
The Opportunity
- Own operational strategy across multiple clinical trials and/or a full geographic region
- Shape protocol strategy and provide senior input on study design and data collection approach
- Lead vendor/CRO selection strategy and own contract negotiation leverage across trials
- Serve as the escalation point for vendor or site issues CTMs can’t resolve on their own
- Own program-level budget forecasting and proactively flag financial risk across the portfolio
- Mentor and develop CTMs and CTAs, providing hands-on guidance and informal supervision
- Lead audit readiness strategy and serve as the point person across multiple trials during inspections
- Represent Clinical Operations at the program or franchise level, and represent Nurix externally at professional events
- Anticipate risk across the trial portfolio and shape process or strategy to prevent issues before they surface
- Lead cross-functional strategic initiatives rather than simply participating in them
What You’ll Bring
- S./B.A. in biological sciences with 8-10+ years of relevant industry experience
- Ability to travel as required for the program (25%)
- Deep working knowledge of FDA, EMA, ICH, and GCP regulations and guidelines
- Proven experience managing global trials or multi-region programs
- Track record leading vendor/CRO relationships at a strategic, not just operational, level
- Experience mentoring or developing junior CTMs/CTAs
- Strong executive presence and ability to influence without direct authority
- Comfortable operating with minimal oversight and setting direction for others
- Outstanding organizational skills, able to manage a portfolio of trials simultaneously
- Thrives in a fast-paced, small-company environment, adjusting priorities as needed
Salary Range: $181,900 – $193.827 annually
The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.
Location: Onsite – Brisbane, CA
Fit with Nurix Culture and Values
- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view
About Nurix Therapeutics
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Skills Required
- Bachelor's or equivalent degree in biological sciences
- 8–10+ years of relevant industry experience
- Ability to travel as required, approximately 25%
- Working knowledge of FDA, EMA, ICH, and GCP regulations and guidelines
- Experience managing global trials or multi-region programs
- Strategic leadership of vendor and CRO relationships
- Experience mentoring or developing junior CTMs or CTAs
- Strong executive presence and ability to influence without direct authority
- Ability to operate with minimal oversight and set direction for others
- Outstanding organizational skills and ability to manage multiple trials simultaneously
- Ability to work in a fast-paced, small-company environment
What We Do
Nurix Therapeutics discovers drugs that harness the body's natural process to control protein levels. Our drugs control ubiquitin E3 ligases, the key enzymes responsible for protein breakdown in human cells, as a unique therapeutic approach to treat a broad range of diseases. Our focus is on developing drugs to treat cancer including novel, small molecule immuno-oncology agents
