The Role
Build and maintain the MetaBiome platform: design bioinformatics architecture and reproducible pipelines for shotgun metagenomics, implement cloud-based data engineering and REST endpoints, lead statistical analyses and methods development, integrate clinical ontologies, and contribute frontend/backend interfaces while ensuring QC, security, and compliance.
Summary Generated by Built In
Senior Bioinformatics Engineer
Compensation: $125K – $200K base + 0.25% - 0.5% equity stock options
About BiomeSense
BiomeSense is a life sciences startup applying gut microbiome (GMB) technologies (GutLab, MetaBiome) to advance personalized medicine. We partner with UCSF, UCSD, NIH & the University of Chicago & are backed by LabCorp Ventures, Bluestein Ventures, Seerave Foundation & Emil Capital Partners.
Position
Help build our MetaBiome platform, a software solution for collecting, curating & analyzing longitudinal GMB & health data at scale. Own the infra, pipelines & analytical workflows that turn raw sequencing data into intelligence, with room to grow into a platform leader.
Responsibilities:
Qualifications
Required
Preferred
Compensation: $125K – $200K base + 0.25% - 0.5% equity stock options
About BiomeSense
BiomeSense is a life sciences startup applying gut microbiome (GMB) technologies (GutLab, MetaBiome) to advance personalized medicine. We partner with UCSF, UCSD, NIH & the University of Chicago & are backed by LabCorp Ventures, Bluestein Ventures, Seerave Foundation & Emil Capital Partners.
Position
Help build our MetaBiome platform, a software solution for collecting, curating & analyzing longitudinal GMB & health data at scale. Own the infra, pipelines & analytical workflows that turn raw sequencing data into intelligence, with room to grow into a platform leader.
Responsibilities:
- Bioinformatics Architecture & Infrastructure - design, implement & maintain auditable backend for GMB data from raw shotgun metagenomic sequencing
- Data Engineering – build & maintain cloud infra: databases, distributed computing workflows & REST endpoints for microbial sequence & clinical metadata
- Statistical Analysis – Lead design, execution & documentation of reproducible computational experiments end-to-end
- Methods Development – Develop & implement novel analytical methodologies & algorithms informed by experimental findings & validated via rigorous evaluation
- Frontend / Backend Development – Design & implement robust data ingestion interfaces leveraging APIs & clinical ontologies, following best practices
Qualifications
Required
- B.S. /M.S. /PhD in Computational Biology, Bioinformatics or a related field with 3+ yrs industry experience (biotech start-up ideal)
- Proficiency in Python & JavaScript & experience in production-quality software
- PostgreSQL or other relational SQL database proficiency
- Familiarity with clinical ontologies (SNOMED, ICD-11, ATC, LOINC)
- Familiarity with AWS & best practices in computer security
- Proficiency with modern frontend web technologies
- Excellent communication; translates complex scientific concepts to diverse stakeholders
- Strong ownership mindset & the ability to execute in fast-moving environments
- Expertise in bioinformatics pipelines, QC & reproducibility
Preferred
- NGS data experience
- Familiarity with longitudinal / repeated-measures biological datasets & GMB-specific challenges (compositional data, variability, confounders)
- Experience integrating ontologies / standardized vocabularies
- Exposure to cloud infrastructure, workflow orchestration or containerization
- Interest in AI/ML for large biological datasets
Skills Required
- B.S./M.S./PhD in Computational Biology, Bioinformatics, Computer Science or related with 3+ years industry experience
- Strong proficiency in Python
- Strong proficiency in JavaScript
- Proficiency with PostgreSQL or other relational SQL database systems
- Familiarity with clinical ontologies such as SNOMED, ICD-11, ATC, and LOINC
- Familiarity with Amazon Web Services and computer security best practices
- Proficiency with one or more modern frontend web technologies
- Excellent communication skills for presenting complex scientific concepts
- Strong ownership mindset and ability to execute in fast-moving environments
- Strong fundamentals in bioinformatics pipelines, QC, and reproducibility
- Experience working with NGS data, pipeline verification, and microbiome-specific challenges
- Familiarity with longitudinal / repeated-measures biological datasets
- Experience integrating external ontologies or standardized vocabularies
- Exposure to cloud infrastructure, workflow orchestration, or containerization
- Interest in AI/ML applications built on large biological datasets
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The Company
What We Do
BiomeSense is a biotechnology company developing an integrated biosensor and AI-powered platform to massively scale the collection and analysis of gut microbiome data. By leveraging big data and artificial intelligence, the company provides continuous, longitudinal insights into the human microbiome to unlock the full potential of precision medicine and personalized healthcare solutions.
