Company Description
Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (formerly BT8009), a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC molecule targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, Mass.
Culture is key and all Bicycle employees actively embrace and role model our company values:
- We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.
- We are Dedicated to our Mission. You can’t change the world if you don’t have determination.
- We are One Team. We only succeed when we work together.
Job Description
We are seeking a sharp, detail-oriented accounting professional to support our Finance team. The Senior Accountant will be responsible for preparing and analyzing our U.S. entity close process, various other account reconciliations, the global consolidation and intercompany transactions, equity and lease accounting, as well as other ad hoc projects, as required. The Senior Accountant will report to the Senior Accounting Manager in our Boston-area office in Cambridge, MA. Applicants should demonstrate strong attention to detail, critical thinking and problem-solving skills.
- Perform monthly/quarterly financial statement close activities, including preparation of various account reconciliations
- Responsible for US entity close process, including intercompany invoicing and reconciliations
- Support aspects of the global consolidation and review to ensure accuracy and completeness for financial reporting
- Prepare monthly global equity accounting journal entries and associated analyses, including share-based compensation
- Prepare monthly global lease accounting journal entries and associated reconciliations in accordance with ASC 842
- Assist with financial reporting process (SEC filings of 10-Q/10-K, etc.)
- Responsible for maintaining SOX compliance and proper documentation of various monthly/quarterly internal control workpapers
- Ad-Hoc projects to support the finance and operations teams as required
- As needed, support the global accounts payable and expense reporting process, including the reconciliation of corporate credit card expenses
- Participate in process improvement activities including enhancing current financial processes and leveraging technology to increase efficiencies
- Support various departments with NetSuite assistance regarding contract approvals and purchase orders
Qualifications
- Bachelor’s degree in Accounting or Finance; CPA track is a plus
- Minimum 2 years’ accounting experience (Big 4 Accounting experience and life sciences/Med Devices/Software industries preferred)
- Must possess strong knowledge of accounting principles, including US GAAP and Sarbanes-Oxley
- Strong proficiency in Microsoft Office: Word, Excel, PowerPoint
- Experience with ERP systems, NetSuite is preferred (not required)
- Strong written and verbal communication skills
- Strong organizational skills with the ability to work in a fast-paced environment, prioritize multiple tasks, and meet deadlines while exhibiting strong attention to detail
- Ability to work independently and within a team environment is important
Additional Information
- Flexible working environment
- Competitive reward including annual company bonus
- Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
- Health and Dependent Care Flexible Spending Accounts
- 401(k) plan with a 4% Company match and immediate vesting
- Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
- Employee assistance program
- Employee recognition schemes
- 10 Company holidays
- Competitive Family Leave Policy
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
All your information will be kept confidential according to EEO guidelines.
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
Top Skills
What We Do
We are Bicycle Therapeutics, a clinical-stage biopharmaceutical company. We didn’t wait for the next advance against cancer. We created it.
Based on groundbreaking work conceived in the laboratory of Sir Greg Winter with the help of Professor Christian Heinis, we are pioneering the development of bicyclic peptides, or Bicycles® – a novel class of versatile, chemically synthesized medicines. Bicycles are fully synthetic short peptides constrained to form two loops which stabilize their structural geometry. This constraint is designed to confer high affinity and selectivity, and the relatively large surface area presented by the molecule allows targets to be drugged that have historically been intractable to non-biological approaches. Bicycles represent a unique therapeutic class, combining the pharmacological properties normally associated with a biologic with the manufacturing and pharmacokinetic advantages of a small molecule, yet with no signs of immunogenicity observed to date.
Bicycles can be used as Bicycle conjugates to deliver toxin payloads and to precisely target local immune activation within tumors and as Bicycle T-cell modulators, which activate cytotoxic T-cells while circumventing the limitations of antibody and biologic therapies and better enabling combination therapy. Our lead product candidate, BT1718, is a Bicycle toxin conjugate currently being investigated in a Phase I/IIa open label dose escalation and expansion clinical trial sponsored by Cancer Research UK. BT1718 targets Membrane Type 1 Matrix Metalloproteinase (MT1-MMP), also known as MMP-14, which is highly expressed in many solid tumors.
Our strategic collaborations are based on the ability of Bicycles to address a wide variety of targets. Through collaborations with AstraZeneca, Oxurion, Innovate UK and the Dementia Discovery Fund, we work with companies that have deep therapeutic expertise outside of oncology to enable us to more efficiently develop novel medicines for patients.
