Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
We are seeking a highly motivated and skilled Molecular Biologist to join our dynamic research team in Discovery Chemistry. The successful candidate will play a key role in antibody engineering to support platform development and drug delivery initiatives. This position requires extensive hands-on experience in phage display, antibody engineering, and antibody characterization, supported by a strong foundation in molecular biology.
Responsibilities
- Design and construct mutant phage libraries for antibody affinity maturation or humanization.
- Perform molecular cloning, mutagenesis, antibody gene assembly, and expression vector design.
- Express and purify recombinant antibodies using bacterial and mammalian expression systems.
- Perform binding, specific and in vitro functional assays.
- Collaborate with cross-functional project teams to advance lead antibodies through drug development stages.
- Maintain accurate documentation and present findings at internal meetings.
Requirements
- Ph.D. in Biology, Biochemistry, Molecular Biology, or a related field.
- Hands-on experience with phage display technology for antibody engineering.
- Proficiency in molecular cloning, PCR, and mutagenesis.
- Experience with antibody expression and purification using E. coli, HEK293, and CHO systems.
- Strong analytical and problem-solving skills, with the ability to troubleshoot experiments independently.
- Excellent record-keeping, communication, and collaboration skills.
- Proven ability to adapt to fast pace and evolving research priorities
- Track record of scientific productivity, including peer-reviewed publications, conference presentations, or patents
- Additional experience in molecular biology and/or antibody discovery is highly desirable
Preferred
- Industry or postdoc experience
Arrowhead provides competitive salaries and an excellent benefit package.
Candidates must have current, valid authorization to work in the country where this role is located.
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Skills Required
- Ph.D. in Biology, Biochemistry, Molecular Biology, or a related field
- Hands-on experience with phage display technology for antibody engineering
- Proficiency in molecular cloning, PCR, and mutagenesis
- Experience with antibody expression and purification using E. coli, HEK293, and CHO systems
- Strong analytical and problem-solving skills
- Excellent record-keeping, communication, and collaboration skills
- Proven ability to adapt to fast pace and evolving research priorities
- Track record of scientific productivity
What We Do
Arrowhead Pharmaceuticals is a clinical stage, Nasdaq listed (ticker ARWR) company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, our therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Our RNAi-based therapeutics are at the leading edge of genetic-based therapy with the potential to bring life changing treatments for patients. Our Targeted RNAi Molecule (TRiMTM) platform utilizes ligand-mediated delivery and is designed to enable tissue-specific targeting while being structurally simple. The TRiM platform builds on more than a decade of work on actively targeted drug delivery and offers several advantages including simplified manufacturing and reduced costs; multiple routes of administration; and potential for improved safety. Our employees are nimble, science-driven, and innovative professionals. A career at Arrowhead offers the opportunity to collaborate with top notch scientists to rapidly discover and develop RNAi-based therapeutics to add to our growing pipeline. Research and development activities are located in Madison, WI. Our R&D group includes fully-integrated capabilities for chemistry, biology, and toxicology. Madison is an exciting and sophisticated city that includes state government, the flagship campus of the University of Wisconsin, and major research organizations. Our HQ, clinical and regulatory operations are located in Pasadena, CA. Just north of Los Angeles and resting in the foothills of the San Gabriel Mountains, Pasadena is known for its natural scenic beauty, vibrant cultural and academic environment and rich architectural setting.
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