Scientist, Protein Purification

Scientist, Protein Purification

Position Summary:

Catalent Pharma Solutions is the leading provider of pharmaceutical development services, drug delivery technologies, manufacturing, packaging, and product commercialization services to the global pharmaceutical and biotechnology industry. We employ over 19,000 people in more than 50 facilities worldwide with reported annual revenues of approximately $4 billion. At Catalent, we take pride in providing a shared commitment to build employee capability, and foster a culture of inclusion, where talent and potential are unleashed, and where employees are committed and engaged to achieve results.

Catalent Biologics Emeryville, CA site, formerly the startup company Redwood Bioscience, has developed a proprietary approach for site-specific bioconjugation to produce next-generation antibody-drug conjugates (ADCs). This technology, termed SMARTag®, is based on use of the aldehyde-tag site-specific protein modification technology and Catalent’s novel conjugation chemistry and proprietary, stable linkers. SMARTag is a clinical-stage technology that was named Runner Up for Best Platform at the 2022 World ADC Awards in San Diego, CA. The Catalent Biologics Emeryville site comprises a close-knit team of scientists working cross-functionally with each other to nimbly achieve our goals and milestones. We are a research site, working to develop therapeutic ADC drug candidates for clinical testing. We also continuously strive to improve and expand our technology platform. The team has a focus on publishing papers and filing intellectual property to contribute to the exciting and dynamic field of bioconjugation and drug conjugates.

Catalent Pharma Solutions at our Emeryville, CA location is seeking a Scientist in Protein Purification who will be responsible for the purification and characterization of antibodies and related protein formats (e.g., bispecifics) to support the generation of antibody-drug conjugates using the SMARTag platform. The Scientist, Protein Purification will be skilled in protein purification using AKTA FPLC and other chromatography methods.

This is a full-time position, Monday – Friday, day shift with flexible work hours. This position is based in Emeryville, CA, 94608 in the EmeryStation West campus, at 5959 Horton St., easily accessible by BART / EmeryGoRound, AMTRAK, or car (with private, secured, on-site parking provided).

Catalent is committed to a Patient First culture through excellence in quality and compliance, and to the safety of every patient, consumer, and Catalent employee. 

The Role:

• Primary responsibility for producing and assessing the purity and homogeneity of complex proteins such as engineered antibodies (e.g., bispecifics, Fc-fusions, and/or bioconjugated therapeutics)
• Conducting medium to high throughput antibody purifications generating milligram to gram scale of antibodies for in vitro and in vivo studies
• Through process development approaches and biophysical and biochemical characterizations, candidate will be responsible for optimizing methods and generating data to support and meet timelines for production of a wide variety of antibodies including bispecific and Fc-fusion molecules
• Development and troubleshooting of purification processes for large molecule biotherapeutics from milligram to gram scale, including the development of robust and scalable purification processes
• Test antibody and ADC binding and internalization characteristics through ELISA and flow cytometry-based methods. Hands-on regular us of AKTA-FPLC and protein/antibody purification downstream
• Quality assurance of proteins using HPLC, SDS-PAGE, isoelectric focusing and other analytical techniques
• Identifying and applying new methods to improve the quality of process and product. Share results and ideas across the site’s multi-disciplinary teams. Generate data to support strategic partner relationships, platform development, patents, and publications
• Maintain electronic laboratory notebook and protect intellectual properties of the company
• Other duties as assigned

The Candidate:

• Minimum education requirement of a Bachelor’s in Biology, Chemistry, Biochemistry or a related discipline with 7+ years of additional industry research experience required. Candidates with a PhD and no experience or a Master’s (M.S.) degree with 3+ years of additional research experience will also be considered
• Extensive experience in antibody/protein purification with AKTA FPLC systems using variety of chromatography methods including affinity, ion exchange, hydrophobic interaction, size exclusion, and others
• Must have experience with using HPLC, SDS-PAGE, CD-SDS, isoelectric focusing, and other analytical techniques
• Familiar with biophysical techniques such as light scattering, thermal shift assay and developability assessments
• Understanding DNA manipulations and expression of recombinant proteins in mammalian cells using transient transfection method is a plus
• Knowledge of biochemical assays including ELISA, Octet BLI systems and others will be favorably considered
• Desire and ability to learn new skills to help contribute to our multi-disciplinary teams. Candidates should have a track record of problem solving, collaboration, data management, and strong communication skills
• Physical Requirements: must be able to sit/stand/walk regularly with use of computers/phones on a daily basis. Must be able to lift up to 15lbs

Pay:

• The anticipated salary range for this role in California is $115,000 to $125,000 annually. The final salary offered to a successful candidate may vary, and will be dependent on several factors that may include but are not limited to: the type and length of experience within the job, type and length of experience within the industry, skillset, education, business needs, etc. Catalent is a multi-state employer and this salary range may not reflect positions that work in other states.

Why you should join Catalent:

• Awesome team collaboration with potential for career growth on an expanding team within an organization dedicated to preserving and bettering lives 
• Defined career path and annual performance review and feedback process 
• Diverse, inclusive culture with several Employee Resource Groups focusing on D&I
• 152 hours of PTO + 8 paid holidays
• Dynamic, fast-paced work environment
• Positive working environment focusing on continually improving processes to remain innovative
• Community engagement and green initiatives 
• Generous 401K match
• Medical, dental and vision benefits effective day one of employment 
• Tuition Reimbursement – Let us help you finish your degree or earn a new one!
• WellHub program to promote overall physical wellness 
• Perkspot - offers exclusive or private discounts from approximately 900+ merchants in a wide array of categories

Catalent offers rewarding opportunities to further your career! Join the global drug development and delivery leader and help us bring over 7,000 life-saving and life-enhancing products to patients around the world. Catalent is an exciting and growing international company where employees work directly with pharma, biopharma and consumer health companies of all sizes to advance new medicines from early development to clinical trials and to the market. Catalent produces more than 70 billion doses per year, and each one will be used by someone who is counting on us. Join us in making a difference. 

personal initiative. dynamic pace. meaningful work.

Visit Catalent Careers to explore career opportunities.

Catalent is an Equal Opportunity Employer, including disability and veterans.

If you require reasonable accommodation for any part of the application or hiring process due to a disability, you may submit your request by sending an email, and confirming your request for an accommodation and include the job number, title and location to [email protected]. This option is reserved for individuals who require accommodation due to a disability. Information received will be processed by a U.S. Catalent employee and then routed to a local recruiter who will provide assistance to ensure appropriate consideration in the application or hiring process.

Notice to Agency and Search Firm Representatives: Catalent Pharma Solutions (Catalent) is not accepting unsolicited resumes from agencies and/or search firms for this job posting. Resumes submitted to any Catalent employee by a third party agency and/or search firm without a valid written & signed search agreement, will become the sole property of Catalent. No fee will be paid if a candidate is hired for this position as a result of an unsolicited agency or search firm referral. Thank you.

Important Security Notice to U.S. Job Seekers:

Catalent NEVER asks candidates to provide any type of payment, bank details, photocopies of identification, social security number or other highly sensitive personal information during the offer process, and we NEVER do so via email or social media. If you receive any such request, DO NOT respond— it is a fraudulent request. Please forward such requests to [email protected] for us to investigate with local authorities.

California Job Seekers can find our California Job Applicant Notice HERE.