Join our Mission to Protect Humankind!
Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, periodontitis and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.
WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:
*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.
*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.
*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.
*MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.
Requirements
- Assist with design, execution, and interpretation of assays to analyze our drug substances and intermediates which consists of protein, polysaccharides, and protein-polysaccharide conjugates.
- Assays include:
- Microplate assays, both colorimetric (BCA, PicoGreen) and enzyme-based assays (ELISA/MSD)
- HPLC-SEC and RP-HPLC, experience with ChemStation is favorable.
- CE and iCIEF
- Assist in analytical method development of new assays to support novel targets.
- Ability to keep accurate and detailed records of experiments.
- Summarize data and communicate to analytical team.
- Support daily lab operations, sample inventory and sample shipment.
- Work within a team environment and provide support to further team objectives.
- Provide technical direction, mentorship and coaching to junior team members.
- Complete any assigned tasks in high quality and in a timely manner.
Essential Functions
- PhD in Chemistry, Analytical Chemistry, Biochemistry, or related field with 4+ years relevant industry experience; MS with 8+ years or BS with 12+ years of industry experience in Pharma/ Biotech industry required.
- Experience with analytical development for biologics (or small molecules) experience with vaccines, carbohydrate, or conjugates is a plus. Techniques include U/HPLC/UV/FLD/RI, SEC-MALS, DLS, CE, SDS-PAGE, mass spectrometry, and many other analytical technologies as applied to conjugate vaccine development.
- Understanding of basic principles of analytical method development/ validation/ qualification concepts.
- Able to critically review and assess analytical methods under development. May need to provide direction for troubleshooting various issues during method development.
- Attention to detail and excellent skills in record keeping / documentation.
- Critical thinking and ability to analyze data.
- Ability to work with minimum supervision in a fun, cross-functional collaborative environment.
- Good interpersonal skills including ability to communicate effectively both verbally and in written formats.
Reports to: Group Leader, Research Analytical Development, Research
Location: San Carlos, CA
Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.
Salary Range: $130,000 – $143,000
Send resumes to:
Vaxcyte, Inc.
825 Industrial Road, Suite 300
San Carlos, CA 94070
We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.
What We Do
Vaxcyte is a vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. The Company is developing broad-spectrum conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases. Vaxcyte’s lead candidate, VAX-24, is a 24-valent, broad-spectrum pneumococcal conjugate vaccine being developed for the prevention of invasive pneumococcal disease. Vaxcyte is re-engineering the way highly complex immunizations are made through modern synthetic techniques, including advanced chemistry and the XpressCFᵀᴹ cell-free protein synthesis platform, exclusively licensed from Sutro Biopharma, Inc. Unlike conventional cell-based approaches, the Company’s system for producing difficult-to-make proteins and antigens is intended to accelerate its ability to efficiently create and deliver high-fidelity vaccines with enhanced immunological benefits. Vaxcyte’s pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of greater than 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease. Vaxcyte is driven to eradicate or treat invasive bacterial infections, which have serious and costly health consequences when left unchecked.
