Scientist II, Bioinformatics

Scientist II, Bioinformatics

PacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems.  Our mission is to enable the promise of genomics to better human health. Genomics is core to all biological processes, and our advanced genomics tools provide scientists and clinical researchers the insights to better understand biology and health.  We are now entering the century of biology and genomics is at the heart of the next revolution.  Become part of the new paradigm in gene sequencing and help shape the future of genomic study by joining the PacBio team.

We are seeking a computational scientist to develop and apply long-read sequencing methods in cancer research and human genomics. In this role, you will build software that enables streamlined analysis of PacBio HiFi data, including secondary analysis tools and production pipelines; run large-scale genomic workflows; and interpret results from diverse datasets. You will collaborate closely with internal teams and a broad range of external partners, contribute to our scientific mission, and help drive new insights through HiFi data. We are looking for someone who is thoughtful, motivated to tackle challenging problems, and adaptable enough to work on projects spanning product development and applied research.

Responsibilities:

• Build reliable, well-tested bioinformatic software and end-to-end analysis pipelines

• Apply bioinformatic tools to answer biological questions related to human health, including cancer and rare disease

• Collaborate with external partners in both academia and industry, supporting and leading projects

• Benchmark and evaluate bioinformatic methods

• Communicate scientific findings through oral and written formats, including papers, posters, and talks at national and international scientific conferences

Required Qualifications:

• Ph.D. in a computational or biological field (e.g., bioinformatics, genetics, genomics, computer science)

• Strong programming skills in Rust, Python, or C++

• Proficiency in analyzing large-scale sequencing datasets (e.g., genomics, transcriptomics, epigenomics, genome assemblies)

• Foundational understanding of cancer genetics, human genomics, or RNA biology, with interest in developing deep expertise in these areas

• Basic statistical skills for analyzing large datasets, including visualization, modeling, and quality control

• Track record of scientific publishing, including first-author manuscripts

• Excellent interpersonal, written, and verbal communication skills

Preferred Experience:

• Experience working within large scientific consortia and collaborating closely with both wet-lab and computational teams

• Demonstrated ability to develop and maintain analysis pipelines using WDL or Snakemake

• Experience building and deploying containerized software (e.g., Docker or Singularity)

• Familiarity with modern software development practices

Candidates must have current authorization to work in the United States without the need for present or future sponsorship.

Non-Field Based Employees are required to be onsite Monday-Thursday (Friday work from home).  Depending on the role, some employees may be required to be 100% onsite.

You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties.

All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.

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All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.

If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process, or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact us at 650-521-8000, or [email protected] for assistance.

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