ElevateBio is a technology-driven company powering the industry forward by helping partners realize the potential of their therapies from design to commercialization. We have integrated a differentiated set of technologies, end-to-end services, and industry-leading manufacturing expertise to develop advanced therapies faster and more efficiently.
The Role:
We are seeking a highly skilled mRNA Scientist to join our process development team at ElevateBio. The ideal candidate will have extensive hands-on experience in mRNA synthesis, purification, and characterization. As an mRNA Scientist, you will be responsible for designing, executing, and optimizing experiments related to mRNA production and purification. You will work closely with cross-functional teams to support the tech transfer of mRNA-based therapeutics. Your contributions will be critical in advancing the manufacturing of mRNA-based products here at ElevateBio.
Here’s What You’ll Do:
- Lead the development, optimization, and scale-up experiments for mRNA based processes to achieve desired yields and purity
- Characterize mRNA samples using analytical techniques such as electrophoresis, spectrophotometry, and HPLC/UPLC to ensure product quality and consistency
- Work closely with cross-functional teams, including MSAT, analytical development, and external clients, to support project goals.
- Support the business development team in creating SOWs and proposals for external clients looking to partner for mRNA therapeutics
- Communicate experimental results and progress to internal stakeholders and external clients.
- Contribute to the development of standard operating procedures (SOPs) and technical documents.
Requirements:
Education Requirements
- BS/MS in Microbiology, Bioengineering, Biochemistry, or a related discipline with 8+ years of relevant experience, with a minimum of 4 years in working with mRNA-based therapeutics
Experience Requirements
- Comprehensive mRNA processing experience with hands-on experience in in-vitro transcription (IVT) and plasmid DNA linearization.
- Knowledge in mRNA downstream methods for Tangential Flow Filtration (TFF) and multiple chromatography techniques such as dT Affinity, IEX, and RP-HPLC.
- Experience operating automated chromatography systems (ÄKTA Avant/Pure) and filtration skids (Repligen KrosFlow Kr2i).
- Comprehensive understanding of tech transfer activities around the production of mRNA drug substance
- Expertise in process scaling around mRNA production from bench scale to GMP manufacturing
Preferred Qualifications
- Experience with mRNA-LNP formulation and mixing technologies/equipment
- Ability to use statistical software such as JMP for Design of Experiments (DoE) and data analysis.
- Familiarity with GMP regulations, Quality by Design principles, and preparing regulatory filing documentation.
The budgeted range for this position is $105,000 - $145,000. This range is a good faith estimate of the expected salary range for this position, based on a wide range of factors including qualifications, experience and training, operational and business needs and other considerations permitted by law.
ElevateBio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Skills Required
- BS or MS in Microbiology, Bioengineering, Biochemistry, or a related discipline
- 8+ years of relevant experience
- At least 4 years of experience working with mRNA-based therapeutics
- Hands-on mRNA processing experience, including in-vitro transcription and plasmid DNA linearization
- Knowledge of mRNA downstream processing using Tangential Flow Filtration and dT affinity, ion-exchange, and RP-HPLC chromatography
- Experience operating ÄKTA Avant/Pure automated chromatography systems
- Experience operating Repligen KrosFlow Kr2i filtration skids
- Understanding of tech transfer activities for mRNA drug substance production
- Expertise scaling mRNA production from bench scale to GMP manufacturing
- Experience with mRNA-LNP formulation and mixing technologies or equipment
- Ability to use JMP for Design of Experiments and data analysis
- Familiarity with GMP regulations, Quality by Design principles, and regulatory filing documentation
Elevatebio Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Elevatebio and has not been reviewed or approved by Elevatebio.
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Healthcare Strength — Health coverage is characterized by comprehensive medical, dental, and vision plans with low deductibles and no copays for in‑network mental‑health visits, alongside employer‑paid wellness platforms and fitness reimbursement. Together, these elements indicate robust healthcare support.
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Retirement Support — Retirement benefits include a 401(k) with an employer match and immediate vesting, plus employer‑paid life and disability coverage and access to a 1‑on‑1 financial advisor. This combination signals solid long‑term financial support.
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Parental & Family Support — Family support includes fully paid parental leave, separate sick time and bereavement, and formal administration of federal and state leave programs. These provisions reflect meaningful support for new parents and caregiving needs.
Elevatebio Insights
What We Do
ElevateBio is a technology driven company powering transformative cell and gene therapies today and for many decades to come. The company has assembled industry-leading talent, built world-class facilities, and integrated diverse technology platforms necessary for rapid innovation and commercialization of cell, gene, and regenerative therapies. The company has built an initial technology stack, including gene editing, induced pluripotent stem cells, and protein, viral, and cellular engineering. At the center of the business model is ElevateBio BaseCamp, a centralized R&D and manufacturing company that offers research and development (R&D), process development (PD), and Current Good Manufacturing Practice (CGMP) manufacturing capabilities. The company is focused on increasing long-term collaborations with industry partners while also continuing to develop its own highly innovative cell and gene therapies. ElevateBio's team of scientists, drug developers, and company builders are redefining what it means to be a technology company in the world of drug development, blurring the line between technology and healthcare. ElevateBio is headquartered in Cambridge, Mass, with ElevateBio BaseCamp located in Waltham, Mass.
