Scientist, Biochemistry I or II
PacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our mission is to enable the promise of genomics to better human health. Genomics is core to all biological processes, and our advanced genomics tools provide scientists and clinical researchers the insights to better understand biology and health. We are now entering the century of biology and genomics is at the heart of the next revolution. Become part of the new paradigm in gene sequencing and help shape the future of genomic study by joining the PacBio team.
Position Summary:
This position will be part of development and manufacturing team to assist commercialization of sequencing platforms. They will be responsible for production of recombinant proteins conforming to product specifications. The ideal candidate would have broad knowledge in protein chemistry/molecular biology, and extensive experience in manufacturing protein products under ISO environment. They will be familiar with analytical tools used for characterization of enzymes, and skilled in troubleshooting and developing corrective solutions. The candidate must have strong collaborative and teamwork attributes
Responsibilities:
- Design and execute studies to develop and improve robustness of protein manufacturing processes
- Process protein production orders and execute reagent manufacturing activities in a timely manner
- Maintain records and production environment in compliance with quality standards
- Conduct troubleshooting on issues which arise during routine production
- Maintain, qualify, and validate equipment as appropriate
- Perform quality control tests
- Assist in inventory management and ordering materials
- Collaborate cross-functionally to ensure on-time completion of production builds
- Conduct development and technology transfer of reagent manufacturing processes and documentation
- Conduct new process development and transfer to production
Required Qualifications:
- A minimum of MSc degree in Biochemistry, Protein Chemistry, Molecular Biology, or related scientific discipline
- A minimum of 5 years of experience in the Life Sciences industry
- Experience of minimum of 3 years in recombinant protein production, preferably with DNA polymerases
- Experience working with affinity chromatography, IEX, HIC, and SEC, preferably for recombinant protein from bacterial expression system
- Substantial experience with automated chromatography stations such as AKTA systems
- Experience in analytical methodologies for protein characterization including HPLC, enzyme kinetics, protein quantification, spectrophotometer, SDS-PAGE
- Experience in formulation and filtration techniques, such as TFF
- Team player with the ability to take initiative in a fast-paced environment
- Excellent interpersonal, written, and verbal communication skills
Preferred Experience:
- Experience in PLM and ERP systems
- Experience in ISO 9001 and 13485 regulated environments
- Knowledge of Next-Generation Sequencing
Candidates must have current authorization to work in the United States without the need for present or future sponsorship.
This role is required to be 100% onsite.
You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties.
All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.
All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.
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Salary Range:
$97,400.00 - $168,000.00To all Staffing and Recruiting Agencies: Our Careers Site is only for individuals seeking a job at PacBio. Staffing and recruiting agencies and individuals being represented by an agency are not authorized to use this site or to submit profiles, applications or resumes, and any such submissions will be considered unsolicited. PacBio does not accept unsolicited resumes or applications from agencies. Please do not forward resumes to our jobs alias, PacBio employees or any other company location. PacBio is not responsible for any fees related to unsolicited resumes/applications.
All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.
If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process, or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact us at 650-521-8000, or [email protected] for assistance.
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Skills Required
- MSc degree in Biochemistry, Protein Chemistry, Molecular Biology, or related discipline
- Minimum 5 years experience in the Life Sciences industry
- Minimum 3 years experience in recombinant protein production (preferably DNA polymerases)
- Experience with affinity chromatography, IEX, HIC, and SEC (preferably from bacterial expression systems)
- Substantial experience with automated chromatography systems such as AKTA
- Experience with analytical methodologies for protein characterization (HPLC, enzyme kinetics, protein quantification, spectrophotometer, SDS-PAGE)
- Experience in formulation and filtration techniques such as TFF
- Strong teamwork, initiative, and excellent interpersonal, written, and verbal communication skills
- Authorized to work in the United States without the need for present or future sponsorship
- Experience with PLM and ERP systems
- Experience in ISO 9001 and ISO 13485 regulated environments
- Knowledge of Next-Generation Sequencing
What We Do
At PacBio, we’re devoted to empowering you. Pioneering the future through biology takes vision. You have to look beyond the status quo to what’s possible. We know your vision can reveal the full potential of the genome, advance human health and the health of our planet. And that is why your vision and pursuit are at the very center of what our company does — our product design, our customer support model, our partnerships, and even our identity. We create the world’s most advanced sequencing systems to provide you the most complete and accurate view of genomes, transcriptomes, and epigenomes. Our founders invented a new way to study the synthesis and regulation of DNA, RNA, and proteins. Driven by a desire to advance human health, we’re harnessing advances in biochemistry, optics, nanofabrication, and more. We are passionate about developing products that empower scientists to explore the full spectrum of genetic variation in any organism — from unraveling the mystery of rare diseases to improving the world’s food supply. With world-class service and support, we keep your research progressing so you can focus on finding answers. We encourage you to see the whole picture — and consider us the partner you trust to see it too.
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