Research Lab Program Manager II

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Position Description:

The Research Lab Program Manager II in the Department of Pediatrics Division of Hematology/Oncology will oversee the daily operations of the Barve Laboratory, which studies hematopoietic stem cell (HSC) dysfunction in Sickle Cell Disease (SCD) and other conditions, with a particular focus on senolytic and mobilization-based therapeutic strategies to restore bone marrow health. The ideal candidate will have hands-on experience with murine hematopoietic models, flow cytometry, and HSC transplantation/mobilization assays, together with laboratory management experience. The candidate will conduct preclinical efficacy studies of senolytic agents and HSC mobilization regimens in SCD mouse models, and will support flow cytometry–based and single-cell characterization of hematopoietic progenitor populations. The candidate will oversee operation of the mouse colony, including SCD and humanized models, and will provide technical support and training to postdoctoral fellows, students, and staff in core techniques (CFU assays, flow cytometry). The candidate is also expected to oversee lab inventory, ordering, and workflow optimization, and to help ensure compliance with IACUC and institutional safety protocols. Excellent organizational and communication skills are essential.

Essential Duties and Responsibilities

• Conduct preclinical efficacy studies of senolytic agents (e.g., ABT-263/navitoclax) in mouse models of Sickle Cell Disease.

• Develop, adapt, and execute HSC mobilization protocols in mouse models.

• Perform and adapt single-cell characterization assays for hematopoietic stem and progenitor cells.

• Conduct flow cytometry analysis of HSPC populations, including senescence and DNA damage markers.

• Perform bone marrow and blood collections, CFU assays, and competitive/limiting-dilution transplantation studies.

• Manage the mouse colony, including breeding, genotyping oversight, and compliance with IACUC protocols.

• Provide technical training and support to postdoctoral fellows, graduate students, and research staff.

• Oversee laboratory operations, including inventory, ordering, equipment maintenance, and workflow optimization.

• Assist with data compilation, organization, and preliminary analysis for grant reporting and publications.

• Maintain QA/QC standards for laboratory assays and procedures.

• Ensure compliance with laboratory safety protocols and institutional regulatory requirements.

Preferred Qualifications

• Sample preparation techniques.

• Strong background in research coordination and management.

Competencies

• Experimental execution, performance, and data collection.

• Research Protocol Scientific Terminology Flexible – ability to change directions as needed for the benefit of laboratory.

• Performance Excellence – high responsibility, pleasant to work with, provides timely and accurate information.

• Organized – manages time effectively, keeps tasks appropriately prioritized.

• Critical Thinking – ability to think through issues and identify appropriate options.

• Work Ethic – motivated, diligent, industrious and persistent in the workplace, stays on tasks to completion, works at a fast pace to ensure optimal efficiency.

• Interpersonal – can build effective, strong working relationships with colleagues and management through trust, communication, and credibility.

• Teamwork – ability to work with others, serve others, help others, take directions from others in the interest of moving process and programs forward to the desired outcome

Target Compensation Maximum:

Target Compensation Minimum:

Compensation will be commensurate to candidate experience.

Equal Employment Opportunity

The University of Louisville is an Equal Employment Opportunity employer. The University strives to provide equal employment opportunity on the basis of merit and without unlawful discrimination on the basis of race, sex, age, color, national origin, ethnicity, creed, religion, disability, genetic information, sexual orientation, gender, gender identity or expression, veteran status, marital status, or pregnancy. In accordance with the Rehabilitation Act of 1973 and the Vietnam Era Veteran Readjustment Act of 1974, the University prohibits job discrimination of individuals with disabilities, Vietnam era veterans, qualified special disabled veterans, recently separated veterans, and other protected veterans. The University acknowledges its obligations to ensure affirmative steps are taken to ensure equal employment opportunities for all employees and applicants for employment. It is the policy of the University that no employee or applicant for employment be subject to unlawful discrimination in terms of recruitment, hiring, promotion, contract, contract renewal, tenure, compensation, benefits, and/or working conditions. No employee or applicant for employment is required to endorse or condemn a specific ideology, political viewpoint, or social viewpoint to be eligible for hiring, contract renewal, tenure, or promotion.

Consistent with applicable law, demographic information is collected for aggregate reporting requirements. Demographic information provided through this application is not available to hiring managers/committees and is not considered in hiring or employment decisions.

Assistance and Accommodations

Computers are available for application submission at the Human Resources Department located at 2315 South First Street Walk, Room 02C - Louisville, Kentucky 40292.

If you require assistance or accommodation with our online application process, please contact us by email at [email protected] or by phone 502-852-6258.