At AstraZeneca's Oncology R&D division, we follow the science to explore and innovate. We are working towards treating, preventing, modifying, and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference and have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.
Position Summary
The Research Associate Process Development (PD) contributes to the design and execution of studies to improve clinical manufacturing processes of Neogene portfolio of engineered T cell therapies. Based in Santa Monica, CA, you will report to the Senior Scientist, Process Development.
Responsibilities
- Develop process development studies to improve, scale-up and transfer cGMP manufacturing processes.
- Perform flow cytometry and cell-based assay experiments for the characterization of and optimization of cell therapy manufacturing processes.
- Perform cell culture of T cells in multiple formats including flasks, bags, and bioreactors.
- Collaborate within the project team to interpret study results and contribute to technical discussions for subsequent study design.
- Prepare experimental proposals, technical reports, SOPs and manufacturing batch records.
- Work collaboratively within PD group and with other groups to meet Technical Operation organization goals.
Required Skills
- 6 months practical experience with Flow Cytometry.
- Hands-on experience in primary cell culture, specifically in T cells is highly desirable.
- Knowledge of cGMP manufacturing and regulations and practical experience in GMP operations.
- Knowledge of statistical analysis for process development.
- Demonstrated troubleshooting based on deductive reasoning.
- Able to work with biological and chemical hazards
Education and Experience
- MS degree in Immunology, Cell Biology, Molecular biology, Bioengineering, or relevant degrees or similar BS degree with 1.5+ years relevant experience in pharmaceutical or biotech industries.
#LI-Onsite
The annual base pay for this position ranges from $71,200 to $106,800. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
DE&I Statement
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
Top Skills
What We Do
Neogene Therapeutics is a global, clinical-stage biotechnology company pioneering the discovery, development, and manufacturing of next-generation engineered T cell receptor (TCR) therapies targeting a broad spectrum of solid cancers. With offices in Santa Monica, CA and Amsterdam, the Netherlands, Neogene is aiming to change the paradigm of treatment for solid cancers. Neogene is a member of the AstraZeneca Group
