The Role
Execute in vivo rodent studies to characterize Antibody Oligonucleotide Conjugates for cardiac programs, with primary emphasis on mouse echocardiography. Develop and characterize cardiac disease models, perform ECGs, dosing (IV/SC/IP/RO/IM), blood/tissue collection, necropsy, microdissection, sample handling, data analysis, and present results to multidisciplinary teams.
Summary Generated by Built In
Atrium is a biopharmaceutical company pioneering delivery of RNA therapeutics to the heart to transform the standard of care for people living with cardiomyopathies. Our proprietary technology leverages the targeted RNA delivery platform initially designed at Avidity, which combines the tissue selectivity of mAbs and other targeted delivery ligands with the precision of oligonucleotides.
This unique combination is designed to allow selective targeting of the underlying genetic drivers of disease that were previously undruggable. Through targeted, non-viral delivery of siRNA to cardiac tissues, our approach has the potential to overcome key limitations of nonspecific viral and nanoparticle-based delivery systems, including challenges related to tissue specificity, immunogenicity, and redosing.
This unique combination is designed to allow selective targeting of the underlying genetic drivers of disease that were previously undruggable. Through targeted, non-viral delivery of siRNA to cardiac tissues, our approach has the potential to overcome key limitations of nonspecific viral and nanoparticle-based delivery systems, including challenges related to tissue specificity, immunogenicity, and redosing.
Position Overview:
We are seeking an experienced in vivo Cardiac Biology Associate Scientist to characterize the in vivo properties of novel therapeutic Antibody Oligonucleotide Conjugates that deliver nucleic acids for cardiac programs. Previous experience handling rodents, using various dosing routes, and performing blood and tissue sample collection is required. Experience with mouse anesthesia is also required. Hands-on experience with mouse echocardiography is strongly preferred, and experience with electrocardiography (ECG) is also preferred. The Associate Scientist will closely collaborate with colleagues in preclinical discovery and present scientific results to multidisciplinary teams and senior management.
Responsibilities:
The candidate will be responsible for the execution of in vivo animal studies, with primary emphasis on mouse echocardiography to evaluate cardiac function and structure. Additional responsibilities will include the development and characterization of cardiac disease models, ECG studies, and collection of blood and tissue samples from rodents.
Education and Experience Requirements:
• B.S. degree in the biological sciences with at least 3 years of relevant in vivo animal study experience
• Experience with mouse cardiac disease models and evaluating in vivo cardiac function is highly preferred
• Knowledge of laboratory mouse behavior, anatomy, and guiding principles for animal welfare
• High proficiency in animal handling, various dosing techniques (IV, SC, IP, RO, IM), bleeding techniques (RO, tail, Submandibular, cardiac), necropsy and micro dissection, and sample handling.
• Demonstrate strong skills in aseptic techniques, proper handling of biological samples/specimens, protein biologics, and data collection and analysis.
• Proficient computer and data analysis/management skills - Microsoft Office Suite, Prism, and Electronic Lab Notebook (ELN)
• Strong organizational skills and attention to detail, including the ability to manage several projects simultaneously.
• Demonstrated ability to work effectively with little to no supervision and in a fast-paced and dynamic environment with a diverse team of co-workers
Skills Required
- B.S. degree in biological sciences with at least 3 years relevant in vivo animal study experience
- Experience handling rodents and knowledge of laboratory mouse behavior, anatomy, and animal welfare
- Experience with various dosing techniques (IV, SC, IP, RO, IM) and bleeding techniques (RO, tail, submandibular, cardiac)
- Experience performing blood and tissue collection, necropsy, microdissection, and sample handling
- Experience with mouse anesthesia
- Hands-on experience with mouse echocardiography
- Experience with electrocardiography (ECG)
- Experience with mouse cardiac disease models and evaluating in vivo cardiac function
- Strong skills in aseptic technique and proper handling of biological samples and protein biologics
- Proficient computer and data analysis/management skills (Microsoft Office Suite, Prism, ELN)
- Strong organizational skills, attention to detail, and ability to manage multiple projects
- Ability to work effectively with little to no supervision in a fast-paced dynamic environment
Am I A Good Fit?
Get Personalized Job Insights.
Our AI-powered fit analysis compares your resume with a job listing so you know if your skills & experience align.
Success! Refresh the page to see how your skills align with this role.
The Company
What We Do
Atrium Therapeutics, Inc. is a San Diego-based biopharmaceutical company dedicated to pioneering the delivery of ribonucleic acid (RNA) therapeutics directly to the heart. By focusing on delivering precision RNA medicines to cardiac tissue, the company aims to transform the standard of care for patients living with rare, life-threatening genetic cardiomyopathies and advance the field of precision cardiology.
