Twist Bioscience is expanding our protein capabilities to support a growing portfolio of products. We're looking for a Protein Scientist with strong technical skills, hands-on experience in protein characterization techniques, as well as a passion for troubleshooting sample problems that arise in a manufacturing environment. The primary focus of this role will be affinity and kinetics measurements of antibody/antigen interactions using SPR.
As a member of the IgG Production team, you will perform and analyze antibody binding and other characterization assays, adjusting your approach to accommodate nonstandard requests as needed. You will also be expected to assist manufacturing associates in troubleshooting experiment issues as they arise. You will collaborate with our subject matter experts located in Twist’s San Francisco and Boston labs to ensure assay alignment between the sites. You will also be required to troubleshoot challenges that arise in manufacturing settings as the subject matter expert at Twist Wilsonville. This role provides the opportunity to work cross-functionally with R&D scientists, automation & software engineers, and bioinformaticists in a fast-paced, innovation-driven company.
If you thrive in a multidisciplinary team environment where every day is different, accelerate at executing a variety of processes at the lab bench, and are a creative problem solver with a passion for delivering high-quality results with careful experimental execution, we want you to apply!
Key Responsibilities
- Perform and analyze affinity and kinetics measurements of antibodies produced in our high-throughput production facility
- Implement and troubleshoot workflows for biophysical and functional characterization of IgG and VHH, including analytical SEC, DLS, DSF, HIC, and additional downstream assays as needed.
- Serve as technical lead for protein characterization and help train and assist manufacturing assistants with execution of assays
- Author technical documents, protocols, training guides, and validation reports to ensure smooth process implementation and knowledge transfer.
- Analyze complex experimental datasets and contribute to data-driven troubleshooting and continuous process improvement.
- Collaborate in cross-functional project teams representing protein characterization in core team meetings and contributing to strategic decisions.
- Document work in electronic lab notebooks and communicate results to stakeholders clearly and regularly.
Qualifications And Required Skills
- Ph.D. in Protein Chemistry, Biochemistry, Molecular Biology, or a related field, or M.S. with 2–5 years of relevant industry experience.
- Strong hands-on experience in protein purification and characterization techniques.
- Experience characterizing affinity/kinetics (KD, ka, kd) of protein/target interactions using SPR or BLI
- Familiarity with biophysical methods for antibody developability such as SEC, DLS, DSF, HIC, ac-sins, enzymatic activity assays, among others.
- Background in protein chemistry and experience characterizing antibodies is strongly preferred.
- Excellent problem-solving skills, scientific judgment, and attention to detail.
- Strong interpersonal and communication skills with the ability to work in a collaborative, cross-disciplinary environment.
- Ability to troubleshoot, train, and mentor others in experimental workflows and data interpretation
Preferred Skills
- Ability to multitask and thrive in a fast-paced and challenging environment.
- Work cross-functionally within and across the department effectively as a team player.
- Excellent problem-solving capabilities.
- Programming experience (ideally SQL, JSON, or Python) for manipulating and analyzing large datasets.
- Familiarity with various sequencing platforms such as Illumina NGS.
- Experience with various high-throughput automation platforms.
About Twist Bioscience
Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.
At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care,agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.
Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.
Skills Required
- Ph.D. in Protein Chemistry, Biochemistry, Molecular Biology, or related field; or M.S. with 2-5 years relevant industry experience.
- Hands-on experience in protein purification and characterization techniques.
- Experience characterizing affinity/kinetics (KD, ka, kd) of protein interactions using SPR or BLI.
- Familiarity with biophysical methods for antibody developability: SEC, DLS, DSF, HIC, AC-SINS, and enzymatic activity assays.
- Ability to troubleshoot experimental issues, support manufacturing associates, and serve as technical lead and trainer.
- Author technical documents, protocols, training guides, and validation reports; document work in electronic lab notebooks.
- Strong problem-solving skills, scientific judgment, attention to detail, and strong interpersonal/communication skills for cross-functional work.
- Background in protein chemistry and experience characterizing antibodies.
- Programming experience for manipulating and analyzing large datasets (ideally SQL, JSON, or Python).
- Familiarity with sequencing platforms such as Illumina NGS.
- Experience with high-throughput automation platforms.
- Ability to multitask and thrive in a fast-paced environment; effective cross-functional teamwork.
What We Do
Twist Bioscience is a synthetic biology company based in South San Francisco, California. The company has developed a proprietary silicon-based manufacturing process for the production of synthetic DNA. Twist Bioscience serves Life Science researchers who are changing the world for the better. Coming from diverse fields of medicine, agriculture, industrial chemicals and data storage, scientists use our synthetic genes, oligo pools, and NGS target enrichment to better lives and improve the sustainability of the planet. Twist Bioscience is uniquely positioned to help accelerate these efforts by providing precision at a scale that is otherwise unavailable. Our technology overcomes inefficiencies and enables cost-effective, rapid, precise, high-throughput DNA synthesis and sequencing. We offer both the quality and quantity researchers need now to rapidly realize opportunities ahead.
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