Protein Scientist

Reposted 5 Days Ago
Be an Early Applicant
Portland, OR
In-Office
Mid level
Biotech
The Role
The Protein Scientist will develop workflows for protein characterization, support transfers to production, and collaborate with teams for troubleshooting and process improvement.
Summary Generated by Built In
Protein Scientist (Onsite in Wilsonville, OR)Job Description

Twist Bioscience is expanding our protein capabilities to support a growing portfolio of products. We're looking for a Protein Scientist with strong technical skills, hands-on experience in protein characterization techniques, as well as a passion for developing and implementing new technologies in a manufacturing environment.

As a member of the Tech Transfer team, you will develop, troubleshoot, and refine methods to establish robust workflows that can be seamlessly executed by the manufacturing team for high-throughput processing. You will collaborate with our subject matter experts located in Twist’s San Francisco and Boston labs as well as with manufacturers to bring new capabilities into production. You will also be required to troubleshoot challenges that arise in manufacturing settings as the subject matter expert at Twist Wilsonville. This role provides the opportunity to work cross-functionally with R&D scientists, automation & software engineers, bioinformaticists, and manufacturers in a fast-paced, innovation-driven company.

If you thrive in a multidisciplinary team environment where every day is different, accelerate at executing a variety of processes at the lab bench, and are a creative problem solver with a passion for delivering high-quality results with careful experimental execution, we want you to apply!  

Key Responsibilities
  • Design and implement workflows for biophysical and functional characterization of IgG and recombinant proteins, including SEC, DLS, DSF, BLI, SPR, MS, and additional downstream assays as needed.
  • Support the transfer of protein-based workflows to production, including method optimization, documentation, and training of manufacturing staff.
  • Lead efforts to insource protein production, including evaluation of expression systems, purification workflows, and performance benchmarking.
  • Author technical documents, protocols, training guides, and validation reports to ensure smooth process implementation and knowledge transfer.
  • Analyze complex experimental datasets and contribute to data-driven troubleshooting and continuous process improvement.
  • Collaborate in cross-functional project teams representing protein science in core team meetings and contributing to strategic decisions.
  • Document work in electronic lab notebooks and communicate results to stakeholders clearly and regularly.
Qualifications And Required Skills
  • Ph.D. in Protein Chemistry, Biochemistry, Molecular Biology, or a related field, or M.S. with 2–5 years of relevant industry experience.
  • Strong hands-on experience in protein purification and characterization techniques.
  • Familiarity with analytical methods such as SEC, DLS, DSF, BLI, SPR, MS, enzymatic activity assays, among others. 
  • Background in protein chemistry is strongly preferred.
  • Excellent problem-solving skills, scientific judgment, and attention to detail.
  • Strong interpersonal and communication skills with the ability to work in a collaborative, cross-disciplinary environment.
  • Ability to troubleshoot, train, and mentor others in experimental workflows and data interpretation
Preferred Skills
  • Ability to multitask and thrive in a fast-paced and challenging environment.
  • Work cross-functionally within and across the department effectively as a team player.
  • Excellent problem-solving capabilities.
  • Programming experience (ideally SQL, JSON, or Python) for manipulating and analyzing large datasets.
  • Familiarity with various sequencing platforms such as Illumina NGS.
  • Experience with various high-throughput automation platforms.
  • Understanding of ISO 13485 and regulated environments for molecular diagnostics or NGS kits.
About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

Top Skills

Bli
Dls
Dsf
High-Throughput Automation Platforms
JSON
Ms
Python
Sec
Spr
SQL
Various Sequencing Platforms
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The Company
Carlsbad, CA
657 Employees
Year Founded: 2013

What We Do

Twist Bioscience is a synthetic biology company based in South San Francisco, California. The company has developed a proprietary silicon-based manufacturing process for the production of synthetic DNA.
Twist Bioscience serves Life Science researchers who are changing the world for the better. Coming from diverse fields of medicine, agriculture, industrial chemicals and data storage, scientists use our synthetic genes, oligo pools, and NGS target enrichment to better lives and improve the sustainability of the planet.
Twist Bioscience is uniquely positioned to help accelerate these efforts by providing precision at a scale that is otherwise unavailable. Our technology overcomes inefficiencies and enables cost-effective, rapid, precise, high-throughput DNA synthesis and sequencing. We offer both the quality and quantity researchers need now to rapidly realize opportunities ahead.

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