Regeneron’s Late-Stage Purification Development team within PMPD (Preclinical Manufacturing and Process Development) is seeking a full-time Process Development Engineer I. In this role, you will be responsible for the development and transfer of the harvest, affinity chromatography, and viral inactivation unit operations for recombinant proteins using Quality by Design principles.
A Typical Day in the Role Might Look Like:
- Designs and executes experiments at both bench and pilot-scale
- Analyzes data, draws conclusions from results, and proposes next steps
- Documents results in laboratory notebook and reports
- Communicates findings to functional area and department leadership
- Acts as purification development subject matter expert during manufacturing process transfer to ensure successful completion of GMP batches
- Works cross-functionally with the process development team to enable a robust, cohesive manufacturing process
- Supports technology development and improvement activities potentially including but not limited to: automation of pilot-scale unit operations, improving bench-scale process models, developing workflows for compilation and analysis of historical data, investigating new raw materials, equipment, and/or techniques to advance the harvest, affinity chromatography, and viral inactivation unit operations
- Trains peers and directly or indirectly manages, mentors, and assists co-op students and interns in conducting experiments, analyzing data, and documenting results.
- Contributes to lab equipment maintenance and general lab safety to help create a safe, effective, and efficient working environment
This Role Might Be For You If You:
- Have a solid understanding and practical experience in purifying monoclonal antibodies or other biopharmaceuticals
- Enjoy spending ~50-70% of time performing lab work at both bench and pilot-scale
- Have experience with process automation, specifically hardware, control logic, and/or HMI development
- Thrive in a team-based, collaborative environment
- Are well organized and able to manage multiple projects efficiently
- Are an effective communicator within all levels of an organization
- Are scientifically curious, creative, and have a problem-solver mentality
This role requires a Bachelor’s and/ or Master’s degree in either Chemical Engineering, Biochemical Engineering, Biochemistry, or a related field with 3-5/0-2 years of recombinant protein purification experience, including some but not limited to depth filtration, disc stack centrifugation, column chromatography, virus retentive filtration, ultrafiltration/diafiltration, buffer preparation. A strong fundamental understanding of various protein purification techniques and experience with Akta chromatography systems, HPLC, UPLC, Empower, Unicorn, JMP, LIMS, Python, Ignition, and PI Historian is a plus.
#pmpd
Intro To PMPD Video:
https://www.youtube.com/watchv=pAboGKlI1zw&list=PL_7lj13Lp4fH4OssUue8J5bby6muZsaR4&index=5
Intro To PMPD Purification Video:
https://www.youtube.com/watchv=aZ82TmphmfA&list=PL_7lj13Lp4fH4OssUue8J5bby6muZsaR4&index=6
Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other countries’ specific benefits, please speak to your recruiter.
Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regeneron’s roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regeneron’s on-site policy and expectations for your role and your location.
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.
For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.
Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.
Salary Range (annually)
Top Skills
What We Do
At Regeneron we believe that when the right idea finds the right team, powerful change is possible. As we work across our expanding global network to invent, develop and commercialize life-transforming medicines for people with serious diseases, we’re establishing new ways to think about science, manufacturing and commercialization. And new ways to think about health. Connect with us so we can learn more about you, and you can learn more about our biopharmaceutical medicines. And join us, as we build a future we believe in.
Please visit www.regeneron.com/social-media-terms for information on how to engage with us on social media.
An important note about privacy: Regeneron is committed to your privacy and will not ask for sensitive personal information such as social security number, date of birth or bank account details via email or social media.
.png)
