Principle Scientist, Protein Engineering & Biotherapeutic Discovery

ROLE SUMMARY
Pfizer's Biotherapeutic Discovery group in La Jolla is seeking an outstanding, highly motivated, and proven protein engineering expert. The candidate will be responsible for developing biologics, with a primary focus on engineering next-generation biologics and hit identification/lead optimization of antibodies. Additionally, the candidate will work closely with individuals in both protein engineering and biology groups to innovate and develop the next generation of protein therapeutics. The candidate will have access to state-of-the-art protein and antibody engineering technologies and will be expected to continue our tradition of developing world-class methods and technologies that enhance our therapeutic discovery efforts.
ROLE RESPONSIBILITIES

• Engage with therapeutic areas to design and apply new antibody MOAs at the interface of biology and molecular engineering.
• Carry out hands-on lab work to apply protein engineering principles to the generation of novel protein therapeutics.
• Conduct antibody discovery against challenging membrane targets.
• Work in teams to develop next-generation therapeutics and influence project teams in their decision-making.
• Stay informed with literature and scientific advancement in the biologics discovery and engineering field.
• Present experimental designs and results at internal and cross-function team meetings.

BASIC QUALIFICATIONS

• Ph.D. in Biological Science (Structural Biology, Protein Biochemistry, Molecular Biology) required.
• Minimum 5 years post-graduate experience in academia or industry.
• Proven scientific achievements through publications or intellectual property.
• Extensive technical skills in protein expression, purification, molecular biology, and structure-function relationships.
• Proficient hands-on experience in protein/antibody engineering and structural biology.
• Strong understanding of antibody structure/sequence and antibody behavior/function relationship.
• Experience in antibody discovery projects.
• Innovative with a successful record in biologics design, creative problem-solving, and strong analytical skills.
• Collaborative scientist with broad interests, diverse background, and ability to work across disciplines.
• Excellent interpersonal, collaborative, and oral communication skills.
• Capable of analyzing and applying relevant published work.

PREFERRED QUALIFICATIONS

• Antibody discovery against difficult membrane targets.
• Expertise in membrane protein production.
• Motivated to understand biology and innovate new protein-based therapeutics.
• Strategic thinking with an ability to understand program and therapeutic area needs and translate that understanding into an actionable approach.

Other Job Details:

• Last Date to Apply for Job: 22 MAY 2025
• Relocation support available

Work Location Assignment: On Premise
The annual base salary for this position ranges from $102,900.00 to $171,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Research and Development