Position Summary:
The Principal Scientist will be instrumental in helping Precision achieve its goals of delivering exceptional services to Precision’s diverse, innovative and global biopharmaceutical clients. Working closely with the Senior Vice President, Lab Operations they will help implement the strategic scientific plan to support translational medicine research, primarily, but not solely, in the Immuno-Oncology and autoimmune/inflammatory space. Key components will be focused on, design and development of innovative qualified and validated immunophenotyping (including high content flow cytometry assays up to 31 markers, receptor occupancy assays, tetramer/dextramer assays as well as immunophenotyping flow based assays), and antigen specific (ELISpot/Fluorospot) or other custom cell based assays. The successful candidate will assist and be a resource for senior team members to design experimental plans and timelines, that match client specifications/requirements. They should and be able to communicate the plan and progress to the client, along with executing and reporting the work according to agreed timelines and under the appropriate regulations (GLP, CAP, CLIA etc.). A significant aspect of this job is the training and mentoring of more junior scientists and team members in bioservices both in laboratory techniques and in the analysis and presentation of data. The role will provide technical expertise to the laboratory as needed, as well as the expectation is that a large part of training is provided “hands on”.
Essential functions of the job include but are not limited to:
- Provide mentoring, coaching and team leadership to Flow Laboratory team members, hold one-on-one engagement meetings with direct reports, set goals, conduct performance reviews and set priorities for lab work
- Motivate team, share knowledge on FACS, participate in recruitment process and revenue forecasting
- Design and implement cell-based assays to meet client requirements; may include complex flow immunophenotyping assays, primary cell based assays.
- Write and implement standard operating procedures (SOPs) to perform assays to meet client requirements and the level of regulatory compliance needed
- Utilize current SOPs to perform cell assays such as flow immunophenotyping, ELISpot, and other custom cell based assays.
- Generate technical reports and other communications required to present data to clients
- Write posters and papers for submission to conference organizers and peer reviewed journals
- Write reviews and white papers
- On occasion, review and edit client proposals, contract/proposals as appropriate.
- Train scientific staff in the review and presentation of data; including client reports, posters and papers for peer reviewed journals
- Train technical staff how to perform laboratory procedures. Devise and perform validation schema to ensure staff are superbly trained and competent. Maintain and support safe lab practices and environment
- Track and trend laboratory efficiency and quality
- Perform duties with high degree of independence, quality, and efficiency
- Act as internal expert on technical advances and industry trends to anticipate and act as a thought leader to management on all matters of major importance, initiate and/or recommend appropriate courses of action and identify those matters requiring policy interpretation or revision
Promote the company to local, regional, national, and international constituencies through networking, speaking engagements, activity in professional associations and publications
Qualifications:
Minimum Required:
- Must have a Ph.D. in life sciences or relevant field (preferably Immunology, Cellular Biology)
- At least 8 years of full-time post-doctoral laboratory experience
Other Required:
- Strong bench scientist skills around cell-based assays. Hands on flow cytometry experience is required. Preferably with experience in ELISpot and other cell based assays. Core competencies of standard biology laboratory experience e.g. cell isolation, and primary cell based assays.
- Experience with cell sorting, trouble-shooting and client relationships, alliance partnerships and timelines
- Experience in validation/qualification of assays to CAP/CLIA/GLP or ISO guidelines
- Strong organizational skills
- Strong communication skills
- Experienced technical report generation
- The ability to see and differentiate between colors on the full color spectrum
- Ability to lift and carry between 1-15 lbs.; Ability to lift up to 50 lbs. overhead with assistance; frequently required to sit, grasp, and use right/left finger dexterity; May be exposed to a cold freezer environment (Freezer temperatures range between -20ºC -196ºC)
- Must be able to read, write, speak fluently and comprehend the English language
Preferred:
- 10-15+ years’ experience as CORE lab member with leadership role as direct manager to flow cytometry team
- Industrial experience and/or management of outside collaborations is desirable
- Experience with viral infections; cell culture and cell line derivation; nucleic acid (RNA & DNA) extraction from primary human samples; nucleic acid characterization by spectrophotometer, Agilent, and fluorescence-based detection
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Precision Medicine Group is an Equal Opportunity Employer. Employment decisions are made without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status or other characteristics protected by law.
If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact Precision Medicine Group at [email protected].
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Candidates must be legally authorized to work in the country of employment without employer sponsorship.
Skills Required
- Ph.D. in life sciences or a relevant field, preferably immunology or cellular biology
- At least 8 years of full-time post-doctoral laboratory experience
- Strong bench scientist skills with cell-based assays
- Hands-on flow cytometry experience
- Experience with cell isolation and primary cell-based assays
- Experience with cell sorting, troubleshooting, client relationships, alliance partnerships, and timelines
- Experience validating or qualifying assays to CAP, CLIA, GLP, or ISO guidelines
- Strong organizational and communication skills
- Technical report generation experience
- Ability to differentiate colors across the full color spectrum
- Ability to lift and carry 1–15 pounds and lift up to 50 pounds overhead with assistance
- Ability to work in freezer environments ranging from -20°C to -196°C
- Fluent English reading, writing, speaking, and comprehension
- 10–15+ years of experience as a core laboratory member with direct management of a flow cytometry team
- Industrial experience or management of outside collaborations
- Experience with ELISpot and other cell-based assays
- Experience with viral infections, cell culture, and cell line derivation
- Experience extracting and characterizing nucleic acids from primary human samples using spectrophotometer, Agilent, and fluorescence-based detection
Precision Medicine Group Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Precision Medicine Group and has not been reviewed or approved by Precision Medicine Group.
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Healthcare Strength — Health coverage includes medical, dental, and vision with HSA/FSA options, plus disability and life insurance, forming a comprehensive core package. The lineup is presented as robust across wellbeing, time off, and financial security categories.
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Leave & Time Off Breadth — Time off includes generous PTO and paid holidays, along with paid parental leave and adoption assistance. These offerings are positioned as part of a well-rounded benefits suite in the U.S. with similar cores noted in Canada.
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Retirement Support — Retirement programs include a 401(k) with employer match in the U.S. and a group retirement plan in Canada. These elements help establish a competitive total rewards foundation.
Precision Medicine Group Insights
What We Do
We founded Precision Medicine Group in 2012 because we believed there was a transformational opportunity to improve the process of bringing new drugs to market. It involves utilizing technology, data, and human expertise. It is a big challenge that requires diverse talents. Our model involves both nurturing and investing organically and acquiring capabilities that we do not have but critically need. Our core executive team is anchored to this model, building life science services that address fundamental changes in healthcare that are necessary for health and outcomes improvement.
