Principal Scientist or Associate Director, Preclinical and Translational PK/PD Modeling

Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit www.kymeratx.com or follow us on X (formerly Twitter) or LinkedIn. 

• PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.
• COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.
• BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.

The successful candidate will develop translational models (PK, PK/PD, PBPK, QSP) to guide decision-making and help optimize therapeutics for clinical success. This is the ideal role for a motivated and adaptable individual that excels in a fast-paced, highly collaborative environment. You will be embedded within DMPK, an active member of core project teams, and collaborate extensively across diverse functions to establish translational dose/PK/PD/efficacy/safety relationships and support the rapid advancement of multiple drug candidates.

• Develop and implement innovative, fit-for-purpose, quantitative analyses and strategies for translational modeling across preclinical programs (incorporating empirical and mechanistic PK, PK/PD, PBPK, QSP, and/or AI approaches as appropriate) 
• Provide human PK and efficacious dose projections, and drug-drug interaction (DDI) or similar risk assessments
• Design, model, and interpret preclinical in vitro and in vivo PK/PD studies 
• In collaboration with Computer-Aided Drug Design and Clinical Pharmacology colleagues, participate in developing quantitative models to predict molecular and PK/ADME properties of targeted protein degraders
• Establish and maintain strong cross-functional collaborations with Preclinical and Clinical Pharmacology, Biology, Translational Medicine, Toxicology, Medicinal Chemistry, CMC, DMPK, and Informatics colleagues
• Liaise with collaboration partners and CROs to generate data and analyses
• Support IND submissions and other regulatory interactions 

• PhD in quantitative sciences, engineering, applied mathematics, pharmacometrics, pharmaceutical sciences, or related field with 7+ years of relevant industry experience (or MS degree with additional industry experience)
• Proficiency with relevant software and languages including MATLAB/SimBiology, Phoenix/WinNonlin/NLME, R, and/or Julia. Experience with PBPK software such GastroPlus, Simcyp, or PK-Sim is a plus
• Exceptional communication skills with the ability to present technical results to teams with diverse scientific backgrounds
• Prior experience within multifunctional core project teams is required
• Ability to work in a fast-paced matrix environment
• Must have a strong understanding of PK/ADME, pharmacology, translational sciences, PK/PD modeling, and human dose prediction principles, and be able to give clear recommendations for the design of preclinical and clinical studies
• Passion for flexible, fit-for-purpose, data-driven analysis, and applying innovative quantitative solutions to advance drug programs

Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.