About AbbVie
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.
Job DescriptionThe Biotherapeutics and Genetic Medicine (BGM) department at AbbVie is seeking a motivated Principal Research Scientist to join the growing siRNA team. In this role, you will work with the genetic medicine teams to establish siRNA synthesis, purification, and analytical capabilities. You will serve as a subject matter expert in oligonucleotide chemistry and siRNA production, with responsibility for generating high-quality siRNA materials to advance genetic medicine studies.
Responsibilities:
- Lead the siRNA synthesis platform to support various stages of siRNA studies.
- Oversee solid-phase oligonucleotide synthesis, deprotection, purification, desalting, and analytical characterization of siRNA.
- Troubleshoot synthesis, purification, and analytical challenges to improve yield, purity, and scalability.
- Partner with cross-functional teams, including the siRNA screening team, the antibody conjugation group, and CMC, to support platform and project objectives.
- Ensure rigorous documentation, data integrity, and compliance with internal quality standards.
- Track and evaluate emerging technologies and best practices in oligonucleotide and RNA-based therapeutics.
- Manage and develop a team of 2–3 scientists to support program goals and deliver high-quality siRNA materials on time.
- BS, MS, or PhD in chemistry, chemical biology, biochemistry, or a related field, with typically 6+ (PhD), 12+ (MS), or 14+ (BS) years of experience in biotech or pharma.
- Demonstrated expertise in siRNA synthesis, purification, and characterization.
- Strong knowledge of oligonucleotide chemistry, RNA chemistry, conjugation chemistry, and analytical techniques such as HPLC, LC-MS, and UV spectroscopy.
- Demonstrated ability to independently address complex technical problems and drive projects forward.
- Excellent communication, collaboration, and organizational skills.
- Strong track record of presenting complex scientific data to internal and external stakeholders.
- Prior people management experience is a plus.
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term and long-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
https://www.abbvie.com/join-us/reasonable-accommodations.html
Skills Required
- BS, MS, or PhD in chemistry, chemical biology, biochemistry, or related field with significant industry experience (typical: 6+ PhD, 12+ MS, 14+ BS)
- Demonstrated expertise in siRNA synthesis, purification, and characterization
- Strong knowledge of oligonucleotide chemistry, RNA chemistry, and conjugation chemistry
- Experience with analytical techniques such as HPLC, LC-MS, and UV spectroscopy
- Experience in biotech or pharmaceutical industry
- Ability to independently solve complex technical problems and drive projects
- Excellent communication, collaboration, and organizational skills; ability to present complex scientific data
- Prior people management experience (managing/developing a small team)
AbbVie Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about AbbVie and has not been reviewed or approved by AbbVie.
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Retirement Support — 401(k) contributions include a dollar-for-dollar match up to 6% plus an additional annual company contribution tied to age and service. Company-paid life insurance and other financial protections further strengthen long-term security.
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Parental & Family Support — Paid leave programs include up to 12 weeks at 100% for parental leave and separate paid caregiver leave, with eligibility after six months where noted. Adoption and surrogacy reimbursements and family-building resources add further support.
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Healthcare Strength — Health coverage begins on day one with medical, dental, vision, mental health, and prescription benefits, and preventive care covered at 100%. Options such as HSAs/FSAs and coverage for spouses/domestic partners and children up to age 26 broaden accessibility.
AbbVie Insights
What We Do
AbbVie is a global biopharmaceutical company focused on creating medicines and solutions that put impact first — for patients, communities, and our world. We aim to address complex health issues and enhance people's lives through our core therapeutic areas: immunology, oncology, neuroscience, eye care, aesthetics and other areas of unmet need.
