About AbbVie
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.
Job DescriptionAbbVie’s Biotherapeutics and Genetic Medicine (BGM) department is seeking a highly motivated Principal Research Scientist to join our expanding siRNA team. In this role, you will partner with genetic medicine teams to establish a high-throughput siRNA screening platform that advances pipeline innovation through next-generation delivery modalities and supports the discovery of therapeutic leads across multiple disease areas.
Responsibilities:
- Establish and implement a high-throughput siRNA screening platform using automated liquid-handling systems.
- Serve as a subject matter expert in siRNA screening experimental design, execution, and data interpretation.
- Lead research efforts and mentor scientists to advance siRNA optimization, including sequence design and novel chemical modifications, across multiple programs.
- Generate new scientific hypotheses and proposals, improve existing screening workflows, and evaluate emerging technologies in the siRNA field.
- Communicate clearly and effectively with internal siRNA teams and cross-functional collaborators to identify needs and support platform enhancement and program advancement.
- Manage and develop a team of at least 2-3 scientists, providing technical guidance, mentorship, and day-to-day leadership to support program goals.
- BS, MS, or PhD in Molecular Biology, Biochemistry, Chemical Biology, or a related field, with typically 6+ years (PhD), 12+ years (MS), or 14+ years (BS) of relevant experience in biotech or pharma.
- Proven track record in siRNA design, in vitro screening, and potency assays with experience using automated high-throughput platforms (e.g., Hamilton, Tecan).
- Experience with assays including, but not limited to, qRT-PCR, ELISA, and flow cytometry.
- Demonstrated experience in cell culture, including the maintenance of diverse cell lines.
- Prior experience leading siRNA platform initiatives or portfolio programs.
- Experience in animal study design and downstream assays to evaluate genetic medicines is a plus.
- Exceptional interpersonal skills and the ability to build productive working relationships with diverse internal teams and external collaborators.
- Strong track record of presenting complex scientific data to internal and external stakeholders.
- Prior people management experience is a plus.
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
- The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
- We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
- This job is eligible to participate in our short-term and long-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
https://www.abbvie.com/join-us/reasonable-accommodations.html
Skills Required
- BS, MS, or PhD in Molecular Biology, Biochemistry, Chemical Biology, or related field with specified relevant experience (PhD ~6+ years; MS ~12+; BS ~14+)
- Proven track record in siRNA design, in vitro screening, and potency assays
- Experience using automated high-throughput platforms (e.g., Hamilton, Tecan) and automated liquid-handling systems
- Experience with assays including qRT-PCR, ELISA, and flow cytometry
- Demonstrated experience in cell culture and maintenance of diverse cell lines
- Prior experience leading siRNA platform initiatives or portfolio programs
- Exceptional interpersonal and communication skills, including presenting complex scientific data to stakeholders
- Experience in animal study design and downstream assays to evaluate genetic medicines
- Prior people management experience (managing and mentoring scientists)
AbbVie Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about AbbVie and has not been reviewed or approved by AbbVie.
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Retirement Support — 401(k) contributions include a dollar-for-dollar match up to 6% plus an additional annual company contribution tied to age and service. Company-paid life insurance and other financial protections further strengthen long-term security.
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Parental & Family Support — Paid leave programs include up to 12 weeks at 100% for parental leave and separate paid caregiver leave, with eligibility after six months where noted. Adoption and surrogacy reimbursements and family-building resources add further support.
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Healthcare Strength — Health coverage begins on day one with medical, dental, vision, mental health, and prescription benefits, and preventive care covered at 100%. Options such as HSAs/FSAs and coverage for spouses/domestic partners and children up to age 26 broaden accessibility.
AbbVie Insights
What We Do
AbbVie is a global biopharmaceutical company focused on creating medicines and solutions that put impact first — for patients, communities, and our world. We aim to address complex health issues and enhance people's lives through our core therapeutic areas: immunology, oncology, neuroscience, eye care, aesthetics and other areas of unmet need.
