Principal Engineer - Commercial CFC Artificial Intelligence Creation Center

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2 Locations
Hybrid
163K-261K Annually
Artificial Intelligence • Healthtech • Machine Learning • Natural Language Processing • Biotech • Pharmaceutical
We’re in relentless pursuit of breakthroughs that change patients’ lives.
The Role
Use Your Power for Purpose
Technology impacts everything we do. Pfizer's digital and 'data first' strategy focuses on implementing innovative and impactful technology solutions across all functions from research to manufacturing. Whether you are digitizing drug discovery and development, identifying solutions, or making our work easier and faster, you will be making a difference to countless lives. Your contributions will be instrumental in developing and supporting robust software for our business, fostering a culture that promotes innovation, and striving to improve patient care and healthcare outcomes.
About the Team
Our team is dedicated to building AI Solutions for our Customer Facing Colleagues using Salesforce and other Pfizer standard platforms for agent development in partnership with Digital, CMO, BU, and other functions to connect technology, business processes, and user experience. As a team, we develop and own the technology roadmap, maintain the digital strategy, and drive alignment across the enterprise on when to use Agent force AI versus other platforms. We anticipate and prepare for long-term development needs. With our vendors we shape platform roadmaps to meet Pfizer needs.
Our vision is to innovate and engineer breakthrough digital products to power business performance and transform global health.
Key Responsibilities
Technical Leadership
  • Serve as the top technical authority on projects, making decisions on technology choices, design approaches, solution architecture and implementation.
  • Lead and oversee the entire lifecycle excellence of engineering projects, ensuring alignment with architectural vision and adherence to best practices.
  • Responsible for maintaining good code quality by promoting and ensuring secure code hygiene.
  • Responsible for guiding the correct configuration of SaaS solutions to ensure security and compliance.
  • Facilitate the conversation between Enterprise Architects, Business Architects, Vendors and Developers, by providing technical clarity on solution(s) to build and code to write, move content from ideation into delivery to move from concept to reality.

Cross-Team Collaboration
  • Act as a translator between business stakeholders and technical engineers, to ensure that technical, security and privacy considerations are represented in strategic discussions and business objectives are being met by our solutions.
  • Align objectives, dependencies, and schedules across multiple teams to keep teams unblocked, and to ensure seamless projects execution.
  • Collaborate with other Principal Engineers, and through the Principal Engineers Forum, to share best practices, quality standards, address improvement areas, and ensure effective communication of information.
  • Collaborate with security teams to monitor vulnerabilities, implement defenses, and ensure compliance with security best practices.
  • Collaborate with digital operations and support to ensure smooth BAU operations.

Excellence by Design
  • Continuously discover, define, architect, deliver, and enable solutions that support program OKRs.
  • Offer deep technical expertise, providing insights and guidance, ensuring solutions are secure, compliant, scalable, maintainable, and efficient.
  • Advocate for the adoption of best practices, new technologies, automation, and continuous improvement initiatives in both technical and privacy domains.
  • Foster a DevOps model of success by building a culture of shared responsibilities and transparency leading to higher quality and quicker delivery of outcomes.
  • Stay updated on emerging technologies, industry trends, and best practices, and apply this knowledge to improve engineering processes and drive innovation within the organization.

Coaching & Mentorship
  • Provide technical guidance and mentorship to junior and mid-level engineers, facilitate knowledge sharing and taking an active role in supporting the development of the wider team and their careers. Foster a culture of excellence, innovation, and continuous learning within the engineering team.
  • Act on Developer Experience (DX) survey findings and feedback from the engineering team members, to drive continuous improvement initiatives to increase the "Ease of Delivery" of the team.
  • Participate in or lead code reviews, where applicable.

What You Will Achieve
In this role, you will:
  • Develop and lead/co-lead highly complex projects, creating mid-term plans that impact results
  • Leverage relationships to meet the needs of various business units, serving as an advisor to others
  • Act independently on self-initiated projects, using knowledge from others and exercising judgment in complex decisions
  • Review work for effectiveness and business impact and evaluate the work of colleagues
  • Exercise foresight and judgment using knowledge and experience within business units
  • Develop innovative ideas and lead divisional projects, implementing Agile principles across all levels and departments
  • Gain consensus on technical approaches and implementation plans from peers, business sponsors, and management
  • Influence senior management decisions that impact business direction across all customer types
  • Partner with the Global Data Management organization to integrate application solutions and provide leadership for the successful delivery of technical aspects of all Digital Solutions & Emerging Technologies projects

Here Is What You Need (Minimum Requirements)
  • Bachelor's degree with at least 8 years of experience
  • Demonstrated progressive experience successfully designing, delivering, and maintaining Information Technology business solutions
  • Passion for emerging AI technologies and frameworks. Active experimentation with new LLMs and agentic approaches.
  • Experience driving and participating in technical discovery to architect and deliver solutions that meet program business objectives.
  • Experience in Salesforce Admin, App Builder, Platform Developer I AI Specialist, Data Cloud Consultant Additional Architect-level certifications (e.g., Integration Architect).
  • Demonstrated experience in effective organization and time management
  • Minimum 5+ years hands-on experience with Salesforce core platform. Deep knowledge of: Sales Cloud, Service Cloud, Experience Cloud Lightning Web Components, Apex, SOQL/SOSL Salesforce Data Cloud (CDP) and its integration with Agentforce.
  • \\Strong experience in Applied AI, especially: Agentforce, Generative AI, LLMs, RAG pipelines Prompt engineering and agent-based frameworks
  • Experience with: Snowflake, Databricks, BigQuery, Redshift Designing and optimizing data pipelines for training/inference Cloud-native architectures (AWS, GCP, Azure),
  • Design solutions that integrate: Salesforce CRM, Data Cloud, analytics tools External systems via APIs and real-time data ingestion.
  • Ability to explain complex AI/ML concepts to technical and non-technical audiences. Lead workshops, demos, and enablement sessions
  • Extensive experience in software engineering, with a focus on leading complex projects.
  • Strong problem-solving and analytical abilities, with a keen attention to detail.
  • Proven technical leadership skills, mentorship, with the ability to motivate and inspire team members and fellow engineers towards achieving common goals.
  • Exceptional interpersonal skills, with the ability to communicate effectively in a matrix environment with geographically distributed resources, and establish strong partnerships with senior non-technical stakeholders, with a talent to explain complex topics simply.
  • Deep understanding of software development methodologies and best practices for implementing principles of privacy & security 'by design'.

Bonus Points If You Have (Preferred Requirements)
  • Master's degree
  • Certifications as a Salesforce Admin, App Builder, Platform Developer I AI Specialist, Data Cloud Consultant Additional Architect-level certifications (e.g., Integration Architect).
  • Relevant pharmaceutical industry experience
  • Experience in mobile or related emerging technology
  • Knowledge of system integrations
  • Strong analytical and problem-solving skills
  • Excellent communication and interpersonal skills
  • Ability to work collaboratively in a team environment
  • Strong leadership and mentoring skills
  • Experience using common AI tools, including generative technologies such as ChatGPT or Microsoft Copilot, to support problem solving and enhance productivity. Demonstrated curiosity for exploring how these tools can improve outcomes and understanding of responsible AI practices, includingrisk management and ethical use

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
Last day to apply : March 13th 2026
Work Location Assignment: Hybrid. Must be able to work from assigned Pfizer office 2-3 days per week, or as needed by the business
The annual base salary for this position ranges from $162,900.00 to $261,000.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 20.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email [email protected] . This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.
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What the Team is Saying

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Pfizer Compensation & Benefits Highlights

  • Healthcare Strength Health coverage includes comprehensive medical with robust mental‑health networks, plus dental and vision options, and coverage for infertility/family‑building and transgender‑affirming care. Recent U.S. summaries name mental‑health partners and outline multiple plan choices.
  • Retirement Support The retirement program provides a 401(k) with company match plus an additional employer Retirement Savings Contribution, along with financial‑planning support and company‑paid life and disability insurance. These elements are highlighted as part of the core U.S. package.
  • Parental & Family Support Parental leave is described as up to 26 weeks in the U.S. when combining paid non‑medical parental leave with medical recovery where applicable, with exact pay and weeks dependent on circumstances and plan elections. Family‑building support includes egg preservation, adoption, and surrogacy coverage.

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The Company
HQ: New York, NY
121,990 Employees
Year Founded: 1848

What We Do

Our purpose ensures that patients remain at the center of all we do. We live our purpose by sourcing the best science in the world; partnering with others in the healthcare system to improve access to our medicines; using digital technologies to enhance our drug discovery and development, as well as patient outcomes; and leading the conversation to advocate for pro-innovation/pro-patient policies.

Why Work With Us

We are the inventors, the problem solvers, the big thinkers — those who surmount any hurdle to deliver breakthrough medicines to the people who are counting on them the most.

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