Job Description
Position Summary
Vertex is seeking a Full-Stack AI Engineer to help build, extend, and operate our Agentic AI platform end to end. In this role you will develop AI agents and the services, APIs, and interfaces around them, and connect the platform to the systems, tools, and data sources that make AI valuable in real enterprise workflows.
The ideal candidate is a versatile engineer who is comfortable across the stack including backend services and APIs, agent frameworks and orchestration, data and retrieval pipelines, and lightweight front-end experiences with real depth in enterprise integration design, MCP/A2A protocols, event-driven architectures, and authentication patterns. This individual will play a key role in ensuring AI capabilities are embedded into day-to-day work at Vertex and not as isolated proofs of concept, but as production-ready solutions integrated into the enterprise ecosystem.
Key Responsibilities
Platform and integrations: connecting the agentic AI platform to enterprise systems, third-party tools, and business-critical services through MCP, A2A, APIs, webhooks, and event-driven patterns
Agent and service development: building agents, tools, and the backend services that support tool use, orchestration, memory, and action execution
Data and retrieval: making structured and unstructured enterprise content usable by AI workflows through ingestion, retrieval, and grounding patterns
User-facing experiences: building and extending lightweight interfaces, chat surfaces, and developer-facing SDKs and connectors that put agents in the flow of work
Reliability and governance: observability, evaluation, security reviews, and the standards that keep agentic solutions safe and supportable in a regulated environment
Build and ship AI and agentic capabilities end to end—from backend services and APIs to the interfaces and connectors users and developers interact with
Design, build, and maintain integrations between the AI/agentic platform and enterprise systems, internal applications, third-party tools, and business services
Implement secure, scalable connectivity patterns that enable AI agents and workflows to access data, trigger actions, and interact with enterprise platforms
Develop and support integrations using MCP, A2A, APIs, webhooks, and event-driven architectures
Create reusable connectors, SDKs, middleware components, and service patterns that accelerate onboarding of new tools and systems into the AI platform
Implement agent capabilities such as tool use, orchestration, retrieval, and action execution, and tune them for accuracy, latency, and cost
Partner with platform, product, data, security, and enterprise application teams to ensure solutions meet technical, business, and compliance requirements
Design robust authentication and authorization patterns for AI services, including identity propagation, token handling, and access control
Enable AI workflows to interact reliably with core enterprise platforms such as collaboration tools, knowledge systems, workflow tools, and line-of-business applications
Build data and retrieval pipelines that make structured and unstructured sources usable by AI and agentic applications
Implement monitoring, logging, tracing, evaluation, error handling, and alerting across agents and integration services
Ensure solutions are resilient, maintainable, observable, and aligned with enterprise architecture standards
Contribute to platform governance by defining standards, documentation, onboarding guidance, and best practices
Troubleshoot and resolve issues related to connectivity, data exchange, authentication, latency, and downstream service dependencies
Evaluate emerging standards and tools in AI engineering, system interoperability, and enterprise integration to inform platform evolution
Required Qualifications
Bachelor's degree in Computer Science, Information Systems, Software Engineering, or a related technical field; equivalent practical experience may be considered
Experience in software engineering, AI/application engineering, or platform engineering, including shipping production services
Full-stack development experience in Python and/or TypeScript, spanning backend services and APIs plus modern front-end or developer-facing surfaces
Hands-on experience building with LLMs and agent frameworks, including tool calling, orchestration, retrieval-augmented generation, prompting, and evaluation
Strong hands-on experience designing and implementing API-based integrations in enterprise environments
Experience with MCP, A2A, service-to-service communication, or similar integration/interoperability patterns
Strong understanding of event-driven architecture, messaging systems, asynchronous processing, and workflow-based integration design
Experience with authentication and authorization standards such as OAuth, OIDC, SSO, service principals, secrets management, and token-based security
Familiarity with enterprise application integration patterns, middleware, and distributed systems design
Experience building secure, scalable, and reliable production services on modern cloud platforms
Strong problem-solving skills and ability to work across multiple systems, teams, and technical domains
Strong written and verbal communication skills with the ability to document and explain technical approaches clearly
Understanding of AI-native software engineering practices, including effective and responsible use of AI coding assistants and software engineering agents
Technical Skills
Python and/or TypeScript across backend and front-end
LLM APIs, agent frameworks, tool calling, and orchestration
Prompt design, evaluation harnesses, and quality/cost/latency tuning
Retrieval-augmented generation, embeddings, and vector stores
MCP and A2A protocols
REST APIs and service integration
Webhooks and event-driven integration patterns
Enterprise application integration
Authentication and authorization design
OAuth, OIDC, SSO, and token management
Distributed systems and microservices
Messaging and asynchronous processing
Observability, logging, tracing, and monitoring
Data exchange patterns across enterprise systems
Secure connectivity and secrets management
Cloud platforms and cloud-native architectures
Error handling, resiliency, and performance optimization
Versioning, testing, CI/CD, and deployment of production services
Preferred Skills
Experience building or integrating AI and agentic platforms with enterprise tools and business systems
Experience with Microsoft AI and cloud technologies such as Azure AI Foundry, M365 Copilot, and agent frameworks
Familiarity with workflow orchestration platforms and automation frameworks
Experience building reusable connectors or SDKs for platform extensibility
Knowledge of enterprise data platforms, document systems, knowledge repositories, and collaboration tools
Experience with regulated environments such as biotechnology, pharmaceuticals, healthcare, or life sciences
Experience supporting platform governance, security reviews, and technical documentation
Understanding of observability and evaluation practices for complex, multi-system agentic workflows
#LI-HYBRID
Pay Range:
$166,640 - $250,000Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
Hybrid-Eligible Or On-Site EligibleFlex Eligibility Status:
In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Hybrid
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected]
Skills Required
- Bachelor's degree in Computer Science, Information Systems, Software Engineering, or related field (or equivalent experience)
- 8+ years of experience in software engineering, platform engineering, or enterprise integrations
- Hands-on experience designing and implementing API-based integrations (REST APIs)
- Experience with MCP and A2A protocols and service-to-service communication
- Strong understanding of event-driven architecture, messaging systems, and asynchronous processing
- Experience with authentication and authorization standards: OAuth, OIDC, SSO, token management, service principals
- Familiarity with enterprise application integration patterns, middleware, and distributed systems design
- Experience building secure, scalable, and reliable production services
- Experience with secrets management and secure connectivity patterns
- Integration observability: logging, tracing, monitoring, error handling and alerting
- Experience defining architecture, standards, and reusable services for large-scale enterprise environments
- Strong written and verbal communication skills; ability to document and explain integration approaches
- Deep understanding of AI-native software engineering practices and experience establishing governance and best practices
- Experience with cloud platforms and cloud-native integration architectures
- Experience with versioning, testing, deployment, resiliency, and performance optimization of integration services
- Experience integrating AI or agentic platforms with enterprise tools and business systems
- Familiarity with workflow orchestration platforms and automation frameworks
- Experience building reusable connectors or SDKs for platform extensibility
- Knowledge of enterprise data platforms, document systems, knowledge repositories, and collaboration tools
- Experience in regulated environments such as biotech, pharmaceuticals, healthcare, or life sciences
- Exposure to AI platform patterns including tool use, agent execution, retrieval, and action frameworks
- Experience supporting platform governance, security reviews, and integration documentation
- Understanding of observability practices for complex, multi-system workflows
Vertex Pharmaceuticals Compensation & Benefits Highlights
The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Vertex Pharmaceuticals and has not been reviewed or approved by Vertex Pharmaceuticals.
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Parental & Family Support — Policies provide 12 weeks of 100% paid bonding leave for all U.S. parents with additional fully paid time for birth parents. Family-forming supports include adoption and surrogacy assistance, fertility options like IVF and egg cryopreservation, breast‑milk shipping, subsidized childcare, backup care, and a DCFSA match.
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Leave & Time Off Breadth — Time off includes roughly four weeks of vacation, 13 holidays, sick time, and two companywide shutdowns (summer and year‑end). Some roles also include flexible or unlimited time off and paid volunteer time.
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Retirement Support — Programs include a 401(k) plan with employer contributions and an employee stock purchase plan. Filings describe employer contributions occurring in company stock, supporting long‑term ownership.
Vertex Pharmaceuticals Insights
What We Do
Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious and life-threatening diseases. We discovered and developed the first medicines to treat the underlying cause of cystic fibrosis (CF), a rare, life-threatening genetic disease. In addition to clinical development programs in CF, Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases. Founded in 1989 in Cambridge, Massachusetts, our corporate headquarters is now located in Boston’s Innovation District, and our international headquarters is in London, United Kingdom. We currently employ approximately 3,500 people in the United States, Europe, Canada, Australia and Latin America with nearly two-thirds of our staff dedicated to research and development. Vertex is consistently recognized as one of the industry’s top places to work by Science Magazine, The Boston Globe, Boston Business Journal and the San Diego Business Journal. Our research and medicines have also received esteemed recognitions, including the Robert J. Beall Therapeutics Development Award, the French Prix Galien and the British Pharmacological Society awards.
