Preclinical Pharmacology Expert- F/M- CDI

Pierre Fabre is the 2nd largest dermo-cosmetics laboratory in the world, the 2nd largest private French pharmaceutical group and the market leader in France for products sold over the counter in pharmacies.

Its portfolio includes several medical franchises and international brands including Pierre Fabre Oncologie, Pierre Fabre Dermatologie, Eau Thermale Avène, Klorane, Ducray, René Furterer, A-Derma, Naturactive, Pierre Fabre Oral Care. 

Established in the Occitanie region since its creation, and manufacturing over 95% of its products in France, the Group employs some 10,000 people worldwide. Its products are distributed in about 130 countries. 86% of the Pierre Fabre Group is held by the Pierre Fabre Foundation, a government-recognized public-interest foundation, while a smaller share is owned by its employees via an employee stock ownership plan. 

In 2019, Ecocert Environment assessed the Group’s corporate social and environmental responsibility approach in accordance with the ISO 26000 sustainable development standard and awarded it the “Excellence” level.

Pierre Fabre is recognized as one of the "World's Best Employers 2021" by Forbes. Our group is ranked in the Top 3 in the cosmetics industry and in the Top 10 in the pharmaceutical industry worldwide. 

Pierre Fabre Group is committed to Medical Care R&D to bring novel, innovative therapeutic opportunities to patients in need. Oncology is a major priority and constitutes a strategic focus for the Pierre Fabre Group.

The internal R&D pipeline, supplemented with future external opportunities, will be central in shaping the future orientation of Pierre Fabre Medical Care.

We are seeking a talented, highly motivated and experienced Preclinical Pharmacology Expert to join our growing oncology drug discovery group in Toulouse.

The ideal candidate will have extensive experience in pre-clinical in vivo pharmacology and will contribute, with both internal and external partners to define and oversee outsourced in vivo studies. This is an exciting opportunity to directly contribute to drug candidate selection and characterization across different projects.

Key skills and responsibilities

• In depth expertise in in vivo pharmacology: PK/PD/efficacy relationship analyses, biomarker studies, knowledge of relevant mechanistic and disease models to support drug discovery and translational research

• Ability to propose and assess new methodologies and technologies for in vivo (and possibly in vitro) pharmacology evaluation Work internally with Core Team members including drug discovery/PK/toxicology and biomarker team members to establish the in vivo evaluation plan for the research projects

• Identify CROs of choice and coordinate outsourcing of in vivo studies and subsequent investigations as needed

• Oversee study design, analysis and interpretation of in vivo pharmacology studies within the defined timelines

• Thorough understanding of the different therapeutic modalities (small molecules, antibodies including Antibody-Drug-Conjugates) and their specificity related to in vivo pharmacology

• Knowledge of the regulatory and ethical framework related to in vivo activities

• Proficiency in both written and spoken English, with strong presentation and communication skills

• Experience working in a cross-functional and dynamic environment

• Self-motivated and collaborative with ability to work on multiple projects with multi-disciplinary teams and external partners

This position is compatible with teleworking up to 2 days a week after the trial period.

We offer an attractive remuneration/benefits package: Incentives, profit-sharing, Pierre Fabre shareholding with matching contribution, health and provident insurance, 16 days of holidays (RTT) in addition to 25 days of personal holidays, public transport participation, very attractive CE...

Profile

• Master’s degree or PhD in a relevant scientific discipline (e.g., pharmacology, biology) with strong expertise in oncology.

• At least 10 years of experience as in vivo pharmacologist in a pharmaceutical or biotech company.

• Habilitation (Level 1) is required to conduct these animal studies

We are convinced that diversity is a source of fulfillment, social balance and complementarity for our employees, which is why our offers are open to all, without restriction.