Postdoctoral Researcher

UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.

UHN’s vision is to build A Healthier World and it’s only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.

www.uhn.ca

Union: Non-Union
Number of Vacancies: 1
New or Replacement Position: New
Site: Princess Margaret Cancer Centre
Department: Research
Reports to: Principal Investigator
Salary Range: $60,000 - $75,000 annually
Hours: 37.5 hours a week
Shifts: Monday - Friday
Status: Temporary Full-Time (1 year contract)
Closing Date: June 30, 2026

Position Summary

Our lab is a multidisciplinary research program based at the Princess Margaret Cancer Centre (UHN) and closely integrated with the Structural Genomics Consortium (SGC). We operate at the intersection of clinical oncology, experimental biology, and computational genomics, with a focus on decoding chromatin architecture and epigenetic regulation in cancer.

Our work combines 3D genome mapping, functional epigenomics, and multi-omic integration to understand tumor heterogeneity and identify clinically actionable regulatory mechanisms. A central goal of the lab is to translate epigenomic insights into precision oncology strategies, including biomarker development and epigenome-informed therapeutic approaches.

We are seeking a highly motivated Postdoctoral Fellow to lead experimental efforts focused on 3D genome organization in cancer. The successful candidate will drive projects integrating chromatin architecture with transcriptional and regulatory landscapes, using a combination of bulk, single-cell, and spatial epigenomics approaches. The role includes substantial opportunity to develop independent research directions, contribute to high-impact publications, and engage in translational research aligned with precision medicine.

This is an ideal position for candidates interested in working at the interface of experimental and computational epigenomics, within a collaborative and high-impact research environment.

Duties 

• Design and execute independent research projects centered on 3D genome organization in cancer.
• Perform and optimize chromatin conformation assays, including HiChIP, HiC and related targeted 3D genome methods.
• Generate and integrate complementary epigenomic datasets, including ATAC-seq, CUT&RUN, CUT&Tag.
• Contribute to or initiate single-cell and spatial multi-omics projects.
• Work with patient-derived organoid models.
• Perform and optimize NGS library preparation protocols across multiple assay types.
• Collaborate closely with computational scientists for data analysis and interpretation.
• Lead manuscript preparation and contribute to grant development.
• Mentor trainees and contribute to a collaborative lab environment.

• Ph.D. in Molecular Biology, Cancer Biology, Genomics, or a related field, required 
• Strong experimental background in functional genomics and epigenomics assays.
• Hands-on experience with next-generation sequencing (NGS) library preparation.
• Experience with chromatin-based assays, for example ATAC-seq, HiC-based methods, CUT&RUN.
• Proven ability to independently design and execute experiments.
• Strong publication record.
• Excellent communication skills and fluency in English, written and spoken.
• Ability to work effectively in a collaborative, multidisciplinary environment.
• Direct experience with 3D genome assays, such as Hi-C, HiChIP, Capture-C, or related methods, an asset
• Experience with organoid culture systems, an asset
• Exposure to single-cell or spatial genomics technologies, an asset 
• Basic familiarity with computational analysis of genomic data, such as R/Python, an asset

Why join UHN?

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN. 

• Competitive offer packages  
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP https://hoopp.com/) 
• Close access to Transit and UHN shuttle service 
• A flexible work environment  
• Opportunities for development and promotions within a large organization 
• Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.) 

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, to be eligible for consideration. 

All applications must be submitted before the posting close date.

UHN uses email to communicate with selected candidates.  Please ensure you check your email regularly.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.

We thank all applicants for their interest, however, only those selected for further consideration will be contacted.