We are seeking a motivated individual to join our investigations of G protein-coupled receptor (GPCR) signal transduction as it relates to cardiovascular disease, and in particular the molecular basis for adrenergic and angiotensin receptor signaling. Our lab uses a variety of experimental and computational biophysical techniques to characterize protein structure and dynamics in these studies, notably continuous-wave and pulsed EPR methods such as DEER spectroscopy. We have free access to eight internally developed and commercial EPR spectrometers housed within the Department of Biophysics. For a complete list of resources, see https://www.mcw.edu/departments/national-biomedical-epr-center/facilities.
Supervise and independently execute studies related to the project described above, including performing experiments, analyzing data, and disseminating results through presenting at conferences and writing manuscripts. Additionally, our lab works with an extensive network of world-class collaborators to study other aspects of GPCR signaling including biased agonism and allostery, and the post-doctoral fellow is expected to take an active role in one or more of these projects.
Supervise and independently execute studies related to the project described above
Performing experiments, analyzing data, and disseminating results through presenting at conferences and writing manuscripts.
Work with an extensive network of world-class collaborators to study other aspects of GPCR signaling including biased agonism and allostery
Expected to take an active role in one or more of these projects.
Plan, design and execute complex research studies, procedures and protocols.
Participate in discovery projects.
Coordinate research study activities; lead and manage projects.
Oversee organization, synthesis and analysis of data and findings.
Prepare scientific reports, outcome findings and scientific manuscripts.
Participate in meetings with principle investigator and research staff in which you will evaluate/interpret the validity of data, develop methodologies, and design and evaluate lab procedures.
Maintain supplies, may require negotiation with vendors, and track purchase orders.
May oversee the work of laboratory personnel including training and development as well as daily work direction, delegation and establishing priorities.
Other duties as assigned.
Pharmacology, cell signaling, and/or biochemistry of GPCRs
FRET/BRET-based cell signaling assays
Mammalian cell culture and purification of functional membrane proteins embedded in a micelle or lipid (nanodisc) environment
Site-directed mutagenesis for site-specific incorporation of spectroscopic probes (e.g. spin labels or fluorescent labels)
Magnetic resonance, electron paramagnetic resonance
Hardware/software interfacing
Python, MATLAB, LabView, C/C++
Excellent writing skills, as evidenced by first author publications
Required knowledge in biology, chemistry, mathematics, and statistics
Documentation, records management and data utilization skills
Complex problem solving, critical thinking, and resource management
Writing skills
Minimum Required Education: PhD
Minimum Required Experience: 0 years
Preferred Experience: Expertise in GPCR pharmacology and signaling
Work requires occasionally lifting moderate weight materials, standing, or walking continuously.
Occasional exposure to dust, noise, temperature changes, or contact with water or other liquids. Work is performed in an environmentally controlled environment.
Ability to detect and translate speech or other communication required. May occasionally require the ability to distinguish colors and perceive relative distances between objects.
Why MCW?
- Outstanding Healthcare Coverage, including but not limited to Health, Vision, and Dental. Along with Flexible Spending options
- 403B Retirement Package
- Competitive Vacation and Paid Holidays offered
- Tuition Reimbursement
- Paid Parental Leave
- Employee & Family Assistance Program (EFAP)
- Pet Insurance
- On campus Fitness Facility, offering onsite classes
- Additional discounted rates on items such as: Select cell phone plans, local fitness facilities, Milwaukee recreation and entertainment etc.
For a brief overview of our benefits see: Benefits Overview
For a full list of positions see: MCW Careers
At MCW all of our endeavors, from our internal operations to our interactions with our partners, are driven by our shared organizational values: Caring – Collaborative – Curiosity – Inclusive – Integrity – Respect. We are committed to fostering an inclusive environment that values diversity in backgrounds, experiences, and perspectives through merit-based processes and in alignment with all applicable laws. We believe that embracing human differences is critical to realize our vision of a healthier world, and we recognize that a healthy and thriving community starts from within. Our values define who we are, what we stand for and how we conduct ourselves at MCW. If you believe in embracing individuality and working together according to these principles to improve health for all, then MCW is the place for you. For more information, please visit our institutional website.
MCW as an Equal Opportunity Employer and Commitment to Non-Discrimination:
The Medical College of Wisconsin (MCW) is an Equal Opportunity Employer. We are committed to fostering an inclusive community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.
Skills Required
- PhD
- Knowledge of biology, chemistry, mathematics, and statistics
- Pharmacology, cell signaling, and/or biochemistry of GPCRs
- FRET/BRET-based cell signaling assays
- Mammalian cell culture and purification of functional membrane proteins in micelle or nanodisc environments
- Site-directed mutagenesis for incorporation of spectroscopic probes
- Magnetic resonance and electron paramagnetic resonance
- Python, MATLAB, LabVIEW, and C/C++
- Excellent writing skills demonstrated by first-author publications
- Expertise in GPCR pharmacology and signaling
What We Do
The Medical College of Wisconsin brings a synergy between the best medical education, research and patient care.
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