Postdoctoral Research Scientist, Proteomics

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie)

About the Role:Our biologics research team is seeking a motivated, talented and collaborative scientist to apply mass spectrometry-based proteomics to pharmaceutical discovery, including applications in target identification, target engagement and pharmacodynamic biomarkers. The qualified individual will work closely with in-vitro and in-vivo pharmacology as well as project teams to design and execute proteomics studies. The position requires excellent scientific, technical and laboratory skills, strong organizational and communications skills, and enthusiasm for contributing to a fast-paced organization focused on discoveries of novel and differentiated therapeutic candidates.

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Your Contributions (include, but are not limited to):

• Develop robust proteome profiling and quantitation assays, perform in-house experiments on biological samples

• Working closely with the MS team to effectively utilize the state-of-the-art instruments to implement proteomics methodologies that will meet the needs of the stakeholders

• Perform data analysis utilizing commercially available software and in-house developed platforms. Optimize various parameters to maximize the value extracted from acquired data

• Collaborate with project, pharmacology and translational biology teams as the subject matter expert, design and execute studies, analyze data and interpret results

• Maintain high quality standards for in-house studies through sample preparation, data acquisition and analysis, ensure quality and delivery of outsourced studies

• Present data at team meetings, lead discussions to guide decision making, prepare manuscripts for publication

Requirements:

• PhD in chemistry, biochemistry or biology

• Solid understanding of mass spectrometry and current proteomics techniques, hands-on experience on LC-MS instruments, immunoprecipitation and bottom-up sample preparation is required

• Experience on high-resolution TOF and/or Orbitrap mass analyzers is a plus

• Experience in methods including DIA, TMT and chemical labeling is desired

• Working knowledge of data processing software, experience in R or Python is desirable

• Experience to monitor and troubleshoot instrumentation, including mass spectrometers, and associated LCs, to maintain up time

• Strong understanding and experience in documenting all sample preparation, method development notes, author scientific reports/publications and protocols/SOPs

• Strong collaboration skills and the ability to work in / lead cross functional or multidisciplinary projects / teams, with a specific focus on how core technology is successfully applied to achieve the broader goals

• Outstanding organizational skills and the ability to work independently

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​Neurocrine Biosciences is an EEO/Disability/Vets employer.

We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.