Postdoctoral Research Scientist, Gene Therapy Vector Engineering

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie)

About the Role:The Postdoctoral Scientist in Gene Therapy vector engineering will participate in the development of novel AAV-based gene therapies and their process development. Working with our Collaboration Partners and internal colleagues in Research, CMC, and Business Development, the individual will participate in work on new and existing programs.

_

Your Contributions (include, but are not limited to):

• The primary role is to design and produce novel AAV material at various scales to advance gene therapy programs

• Design and execute molecular biology and in vitro experiments in support of AAV capsid and genome engineering

• Prepare data summaries and present results to peers and colleagues at Neurocrine

• Be able to present data as appropriate at scientific meetings at the National and International level

• Other tasks as assigned

Requirements:

• Master's degree in biology, life sciences or related discipline, and experience in the biotech/pharmaceutical industry OR PhD or postdoc experience

• Proficient in molecular biology and cell culture work

• Experience with AAV production preferred, including plasmid transfection, cell material processing, and purification by ultracentrifugation

• Knowledge of AAV vector design including capsid and gene regulatory elements

• Backgrounds in neuroscience, protein engineering, and/or sequencing technologies are a plus

• General knowledge of AAV biology and/or protein engineering

• Experience with molecular biology techniques such as PCR, digital PCR, gel electrophoresis, western blot/ELISA, plasmid design, cloning, and sequencing

• Experience with cell culture in vitro techniques such as cell passage of adherent and suspension cells, sterile technique, media preparation, cell lysis, and material processing

• Experience with NGS sample preparation and data analysis

• Excellent critical analysis skills and ability to assess data and research findings outside of Neurocrine for application to new scientific projects

• Advanced knowledge and demonstrated ability to work with a variety of laboratory equipment/tools

• Ability to work as part of teams

• Excellent computer skills

• Excellent communication skills

• Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency

#LI-DM1

Neurocrine Biosciences is an EEO/Disability/Vets employer.

We are committed to building a workplace of belonging, respect, and empowerment, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.

_

The annual base salary we reasonably expect to pay is $89,800.00-$123,000.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.