Postdoctoral Fellow, Tumor-on-a-chip for PK/PD Predictions

Use Your Power for Purpose
At Pfizer, our purpose is to deliver breakthroughs that transform patients' lives. Central to this mission is our Research and Development team, which strives to convert advanced science and cutting-edge technologies into impactful therapies and vaccines. Whether you are engaged in discovery sciences, ensuring drug safety and efficacy, or supporting clinical trials, your role is crucial. You will leverage innovative design and process development capabilities to expedite the delivery of top-tier medicines to patients globally.
We are looking for a highly motivated postdoctoral fellow with expertise in cell biology or biomedical engineering to join Pfizer's Pharmacokinetics, Dynamics and Metabolism (PDM) Department.
How You Will Achieve it
In this position, the postdoctoral fellow will lead the advancement and validation of microfluidic-based in vitro tumor growth inhibition (TGI) models. With a focus on early prediction of effective concentrations and dosing, this project aims to significantly influence strategies to reduce and ultimately replace in vivo TGI studies. The successful candidate will be exposed to and collaborate with colleagues in oncology biology, proteomics, Translational Modeling and Simulation (TMS) and mass spectrometry.
In this position, you will draw on your background in cell biology and your passion for developing advanced microfluidic in vitro systems to design tumor growth inhibition models for both solid and liquid tumors. You'll incorporate preclinical and clinical pharmacokinetic-pharmacodynamic (PK/PD) data to mimic relevant exposure profiles, will design the appropriate studies to monitor pharmacodynamic response, and work closely with TMS colleagues to establish and validate the correlation between in vitro and in vivo results (IVIVC).
You will also present internally and externally and publish your results from this project.
Here Is What You Need (Minimum Requirements):

• Ph.D. in Biological Sciences, Biomedical Engineering, or a related field with expertise in one more of the following areas as demonstrated through at least one first-author publication: Cell Biology, Oncology, Cell/Tissue Engineering, 3D Complex In Vitro Models/Biophysiological Systems.
• No more than 2 years of post-degree experience.
• Willingness to make a minimum 2-year commitment.
• Successful record of scientific accomplishments evidenced by scientific publications and/or presentations with at least one first-author publication in a peer-reviewed journal.
• Hands on experience in cell biology, assay design and functional readouts of probed biology (e.g., immunofluorescence, imaged-based analysis, multi-omic profiling for translational relevance).
• Strong oral and written communication skills and the ability to work independently and as part of an interdisciplinary team. Ability to adapt and distill complex scientific concepts or experimental design to the level of understanding across the interdisciplinary team.
• Strong problem-solving capability - enjoy complex challenges and driven to explore different approaches to overcome challenges.
• Strong collaborative acumen.

Bonus Points If You Have (Preferred Requirements):

• Familiarity with principles of pharmacokinetics, pharmacodynamics & metabolism.
• Strong grasp of biological systems such as oncology, pathways, and biomarkers.
• Practical experience with microfluidics/dynamic flow cell/tissue culture systems, 2D and 3D cell co-culture, spheroid/organoid culture.
• Familiarity with microfluidic chip materials, microfluidic chip design & fabrication.
• Interest and/or experience in computational modeling of PK/PD.

PHYSICAL/MENTAL REQUIREMENTS

• Lifting, sitting, standing, walking, bending.
• Ability to perform mathematical calculations.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• Majority of work will be performed during the standard workday, but ability to work flexible hours when needed is preferrable.

ADDITIONAL INFORMATION

• Work Location Assignment: On Premise.
• Relocation support: No.
• Last day to apply: September 30th, 2025.

The annual base salary for this position ranges from $62,700.00 to $104,500.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
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Research and Development