Pioneering Medicines Senior Scientist, Translational Research

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines is dedicated to conceiving and developing a broad portfolio of life-changing treatments by leveraging and expanding the use of Flagship’s multiple bioplatforms and Flagship’s proprietary innovation process. By harnessing the power of Flagship’s first-in-category platforms, Pioneering Medicines creates and advances novel medicines, partnering with Flagship companies to accelerate the extension of their portfolios into new areas and show that the platform can be applied more broadly, thereby delivering benefits to more patients, sooner.
With a highly experienced drug development team and access to the wide ecosystem of Flagship companies, Pioneering Medicines is well positioned to conceive new medicine ideas both internally and in collaboration with strategic partners and advance these assets through to significant value inflection. Pioneering Medicines currently has 18 programs ongoing with additional coming soon. Pioneering Medicines works with external strategic partners including Novo Nordisk, Pfizer, and the Cystic Fibrosis Foundation and continues to engage in discussions on potential partnerships.

Position Summary:

Pioneering Medicines is seeking a highly motivated and experienced researcher to drive translational efforts across multiple therapeutic areas and drug modalities. The successful candidate will leverage deep subject matter expertise, scientific acumen and leadership skills, and will work in collaboration with companies across the Flagship Pioneering ecosystem. We are seeking individuals who are analytical, goal-oriented, and timeline-sensitive, while maintaining the highest levels of scientific and ethical standards. Strong communication skills and comfort working in a dynamic and cross-functional team environment are highly desirable.

Responsibilities:

• Generate and interpret translational data to support biomarker discovery, PK/PD and dose predictions, standard-of-care benchmarking, and development of clinically applicable biomarker assays.

• Develop platforms, identify CROs and external collaborators to grow the translational sciences capabilities.
• Opportunity to serve as scientific lead on early discovery projects, guiding cross-functional integration and strategy.
• Leverage translational datasets to identify new targets for early discovery.
• Provide scientific mentorship and training to junior staff, and contribute to the operational strategy of the research team.
• Demonstrate an insatiable curiosity, strong work ethic, and the ability to work equally well in a team or independently.

Required Qualifications & Experience

• Ph.D., with 2+ years or MSc with 5+ years, including some industry experience (or equivalent).
• Understanding of translational research including biomarker discovery, PK/PD/efficacy relationships, dose predictions, and supporting assets into early clinical development.
• Experience in target validation and identifying targets with strong causal human biology.
• Well-versed in various biochemical, cellular, and immunological techniques in the laboratory.
• Experience developing proof-of-concept for novel biomarker assays, suitable for implementation on early phase clinical trials.
• Scientific expertise in immunology, liver disease, cardio/renal/metabolic and/or oncology.
• Ability and interest to work across multiple therapeutic areas and modalities.
• Ability to work onsite at our Cambridge, MA site.

Preferred Qualifications 

• Ability to establish novel protocols or techniques in the lab or at CROs, and to train and mentor junior team members for data delivery.
• Experience working in multiple drug discovery functions in early and late-stage programs.
• Ability to leverage cross-functional approaches to derive translational insights. A strong understanding of translational bioinformatics is highly desirable.
• Experience engaging with key opinion leaders and participating in external scientific collaborations.
• Exhibits an infectious enthusiasm for science/discovery and an eagerness to rise to challenges.

Other Attributes

• Most importantly, curious and a positive, problem-solving can-do attitude.
• Engage enthusiastically and effectively in disparate projects.
• Function independently within the framework of tightly knit project teams.
• Reliably execute on team responsibilities in an efficient manner.
• Be proactive, organized and driven by a fundamental interest in contributing to science in general and drug discovery as a whole.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

About Flagship Pioneering:

Flagship Pioneering is a biotechnology company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture. What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. 

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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The salary range for this role is $146,000 - $184,250. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines’s good faith estimate as of the date of publication and may be modified in the future.