Pioneering Medicines: Senior Research Associate/Associate Scientist, Translational Sciences

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines is dedicated to conceiving and developing a broad portfolio of life-changing treatments by leveraging and expanding the use of Flagship’s multiple bioplatforms and Flagship’s proprietary innovation process. By harnessing the power of Flagship’s first-in-category platforms, Pioneering Medicines creates and advances novel medicines, partnering with Flagship companies to accelerate the extension of their portfolios into new areas and show that the platform can be applied more broadly, thereby delivering benefits to more patients, sooner.
With a highly experienced drug development team and access to the wide ecosystem of Flagship companies, Pioneering Medicines is well positioned to conceive new medicine ideas both internally and in collaboration with strategic partners and advance these assets through to significant value inflection. Pioneering Medicines currently has 18 programs ongoing with additional coming soon. Pioneering Medicines works with external strategic partners including Novo Nordisk, Pfizer, and the Cystic Fibrosis Foundation and continues to engage in discussions on potential partnerships.

Position Summary:

Pioneering Medicines is seeking an innovative, motivated, and highly collaborative Senior Research Associate/ Associate Scientist to join our Translational Sciences team. The position supports translational research activities aimed at bridging the gap between early research and clinical development. This role will be directly accountable on data delivery to support the deep characterization of novel and emerging drug candidates, and/or execution of biomarker assays to evaluate pharmacology of therapeutic molecules. The candidate will be supported by scientific leaders to develop experience and expertise in drug discovery and pharmacology. We are looking for adaptive and scientifically curious individuals who embrace our core values of putting people and patients first, in an environment that encourages growth and learning.

This position is on-site in Cambridge, MA.

Key Responsibilities:

• Deliver impactful datasets to inform the translational direction of drug discovery program(s) (e.g., pharmacodynamic biomarker discovery for disease/patient selection, inform human dose predictions, develop novel biomarker assays)
• Contribute to drug discovery programs supporting translational research goals and strategies.
• Collaborate on capability building to support translational needs and emerging program needs.
• Communicate research plans and data to colleagues with diverse scientific backgrounds.
• Maintain experimental records in an ELN
• Contribute to other prioritized activities and initiatives within the drug discovery group, aligned with team needs and personal interests.

Required Qualifications

• Bachelor or Master of Science degree in biology, immunology, pharmacology or equivalent
•  2+ years’ experience in a laboratory of academia or industry
• Previous experience with ex-vivo assay development in rodent, NHP and human tissues/plasma/whole blood
• Experience working with sterile cell culture techniques for the growth and maintenance of cell lines and primary cells (e.g. peripheral blood mononuclear cells, organoids, explant cultures)
• Prior working experience with in vitro cell based pharmacology assays using human or rodent primary cells
• Hands-on experience with isolating and manipulating primary cells to perform downstream analysis (e.g. MSD/ELISA, FACS, western blots, qPCR, histology, fluorescence microscopy)
• Experience with scientific software (e.g., GraphPad PRISM, imaging software)
• Independence in experimental design and execution, data analysis, interpretation, and presentation 

Preferred Qualifications

• Preclinical research experience that supports early phase clinical studies or is directly related to the understanding of human disease/pharmacology.
• Experience with advanced cell biology techniques (organoid cultures, 3D cell culture models, iPSC manipulation) for use in pharmacology/translational research.
• Experience/understanding in the utility of bioinformatics to inform translational research directions.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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