We are looking for an extremely talented Physician Scientist to join our Immunology Therapeutic Area Genetics (TAG) team. Within the RGC, the Immunology TAG team is using large-scale human exome sequencing for discovery and validation of new therapeutic targets in autoimmune and other immune-mediated disease. You will be responsible for designing and executing studies integrating large scale human genetics and multidimensional omics datasets derived from RGC and public resources in the immunology space to identify new targets for inflammatory and auto-immune diseases and accelerate target transition to novel therapeutics. You will collaborate with various RGC teams and with pre-clinical and clinical development teams at Regeneron to catalyze therapeutic development for genetically-validated targets in immunologic diseases.
In this role, a typical day might include the following:
Understand and leverage RGC and Regeneron datasets, external resources, and the scientific/medical literature to generate research questions and then generate relevant phenotypes from longitiudinal clinical data, design and execute genetic association studies, and perform integrative omics analyses to address these research questions
Deploy computational methods to integrate genetic data with multiple omics data to more effectively identify/prioritize drug targets illuminated by genetic association data.
Work closely with other members of the Immunology and other TAG teams, Analytic Genetics, Sequencing, and GIDE in cross-functional initiatives within the RGC and Regeneron.
Collaboratively summarize insights of investigations into a variety of formats (e.g. documents, presentations, patent applications, publications, etc.) for audiences with broad bacgrounds.
Partner with Clinical Development to evaluate clinical stage programs and opportunities for human genetics studies to aid in the selection of indications or evaluation of safety considerations.
This job might be for you if you can/have
Bring innovative thinking to human genetics and epidemiological studies
Experience leading complex human genetics research incorporating different analytic methods, phenotypes, and study designs.
Ability to use medical knowledge to define relevant phenotypes for genetic association studies and to formulate innovative and important research questions.
Worked with multidisciplinary teams to characterize the functional consequences of discovered disease gene variants
Understanding of drug development and clinical trial design and execution. Experience in the clinical management or medical research relating to autoimmune and immune-mediated disease is a plus.
Experience with clearly and concisely communicating complex genetics/genomics concepts to audiences with broad scientific backgrounds
A strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward within Regeneron.
To be considered for this opportunity, you must have a demonstrated expertise in immunobiology, genetics, and mechanisms; familiarity with large genetic studies that deliver novel genetic findings and medically relevant gene discoveries; and demonstrated ability to manage and collaborate in a multi-disciplinary team, to discover and evolve immunology-related drug discovery pipelines. MD Required, MD/PhD preferred with >3 years of experience in the use of WES/GWAS datasets, RNA-Seq, proteomics and other large-scale platforms for genomic/proteomics. Individuals with proficiency in computational immunology research are particularly encouraged to apply.
Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits, which often include (depending on location) health and wellness programs, fitness centers, equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.
For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.
Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.
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