Passionate about precision medicine and advancing the healthcare industry?
Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.
We are seeking a Senior Scientist to lead the development and validation of new molecular assays and laboratory processes for deployment in our clinical laboratory.
What You’ll Do
Lead development of molecular assays and NGS workflows for high-throughput clinical laboratories.
Design, execute, and analyze R&D studies with scientific rigor and attention to detail.
Lead assay validation and clinical implementation from study design through launch, including workflow development, SOP creation, and documentation.
Design and execute qualification and validation studies for reagents, instruments, equipment, and methods to support clinical deployment.
Interpret data, troubleshoot issues, and drive process improvements.
Collaborate across cross-functional teams and provide scientific leadership in a matrixed environment.
Communicate clearly and effectively with technical and non-technical stakeholders.
Train and mentor junior scientific staff and support implementation of new laboratory workflows.
Support automation and technology initiatives to improve laboratory workflows.
Manage multiple priorities and adapt quickly in a fast-paced environment.
Travel up to 10% as needed.
Qualifications
Ph.D. with 0 or more years of experience, or Master’s degree with 5+ years of relevant experience in molecular biology, assay development, or a related field.
Experience in assay development and/or validation required.
Experience in a clinical laboratory environment required; CAP/CLIA/NYSDOH experience preferred.
Strong analytical, troubleshooting, and experimental design skills.
Highly organized, detail-oriented, and committed to quality and accuracy.
Proven ability to learn quickly and adapt to new processes, technologies, and workflows.
Strong collaboration skills with the ability to lead across teams.
Excellent oral and written communication skills.
Ability to manage competing priorities and deadlines in a dynamic environment.
Preferred Technical Experience
DNA/RNA extraction and purification methods.
NGS library preparation, hybrid capture, and sequencing workflows.
PCR-based techniques, including PCR, qPCR, RT-PCR, and ddPCR.
Nucleic acid manipulation, quantitation, and analysis.
Assay troubleshooting, root cause analysis, and workflow optimization.
Highly Desirable
Experience with FFPE tissue workflows.
Experience with laboratory automation and liquid handling robotics.
Experience developing and implementing protocols for CLIA-regulated laboratories.
Familiarity with LIMS and laboratory data systems.
Pay Range: $95,000 - $120,000 USD
The expected salary range may vary for other locations. Actual salary may vary based on qualifications and experience. Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.
We are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Skills Required
- Ph.D. in molecular biology, assay development, or related field OR Master's degree with 5+ years relevant experience
- Experience in assay development and/or validation
- Experience in a clinical laboratory environment
- CAP/CLIA/NYSDOH experience
- Strong analytical, troubleshooting, and experimental design skills
- Highly organized, detail-oriented, and committed to quality and accuracy
- Proven ability to learn quickly and adapt to new processes, technologies, and workflows
- Strong collaboration skills with the ability to lead across teams
- Excellent oral and written communication skills
- Ability to manage competing priorities and deadlines in a dynamic environment
- Willingness to travel up to 10%
- DNA/RNA extraction and purification methods
- NGS library preparation, hybrid capture, and sequencing workflows
- PCR-based techniques, including PCR, qPCR, RT-PCR, and ddPCR
- Nucleic acid manipulation, quantitation, and analysis
- Assay troubleshooting, root cause analysis, and workflow optimization
- Experience with FFPE tissue workflows
- Experience with laboratory automation and liquid handling robotics
- Experience developing and implementing protocols for CLIA-regulated laboratories
- Familiarity with LIMS and laboratory data systems
What the Team is Saying
Tempus AI Compensation & Benefits Highlights
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Healthcare Strength — Medical, dental, and vision insurance are standard and employer‑verified, complemented by life/disability coverage, HSA/FSA, mental health resources, and EAP. Company materials and verified listings indicate these core benefits are well established as of mid‑2026.
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Leave & Time Off Breadth — Vacation/Paid Time Off, Sick Leave, and Paid Holidays are explicitly offered on employer‑verified pages. Many roles are described as having flexible or unlimited PTO, though laboratory staff may follow separate policies.
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Wellbeing & Lifestyle Benefits — On‑site conveniences such as a cafeteria, stocked kitchens, and an on‑site barista are highlighted for select offices, alongside wellness initiatives, gym discounts, commuter benefits, and charitable matching. These day‑to‑day perks are emphasized on official culture/benefits pages and aligned third‑party summaries.
Tempus AI Insights
What We Do
We bring together one of the world’s largest libraries of multimodal clinical and molecular data with a robust suite of AI tools to help physicians personalize care in real time, connect patients with therapies and clinical trials, and enable partners to accelerate discovery and development of new treatments. With ~8 million de-identified research records and 350+ petabytes of data, Tempus partners with more than half of U.S. oncologists and the majority of the top 20 global pharma companies. Our teams are pioneering work across oncology, neurology, psychiatry, cardiology, and beyond—transforming how care is delivered and therapies are developed. At Tempus, every role contributes to our mission: to help each patient benefit from the experiences of those who came before. For more information, visit tempus.com.
Why Work With Us
We’re looking for people who can change the world. People who question the status quo and refuse to shy away from tough problems. For builders who are never done building, and the learners who are never done learning. Passionate individuals with undying curiosity who want to take on one of the greatest challenges humanity has ever faced—head on.
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Tempus AI Offices
Hybrid Workspace
Employees engage in a combination of remote and on-site work.
Most of the team follows a hybrid policy, with some roles allowing for a fully remote arrangement and some roles being onsite only.
