Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Let’s do something amazing together! The National Account Director (NAD) will play a critical role in enabling patient access to Arrowhead’s first commercial asset – Plozasiran (siRNA targeting APOC3) as well as an expanding pipeline of innovative therapies across multiple therapeutic areas. This product has demonstrated compelling clinical data to date and is in late-stage development for the treatment of various grievous conditions, including Familial Chylomicronemia Syndrome (FCS) and Severe Hypertriglyceridemia (SHTG).
The NAD will develop, execute, and manage strategic relationships with key stakeholders including GPO, PBM, and Plan (Commercial, Medicare, Medicaid) stakeholders to secure formulary access. The ideal candidate will demonstrate the proven ability to build, develop, and lead a high-performing market access team to support Arrowhead’s expanding commercial portfolio. This is a field-based role that requires periodic travel to Arrowhead's Corporate Headquarters in Pasadena, CA, as business needs dictate.
Responsibilities
- Strengthen relationships with GPO, PBM, Commercial, Medicare, and Medicaid plan stakeholders
- Communicate product clinical and economic value to payers, and key decision-makers
- Create and maintain comprehensive account plans supporting launch, and post-launch strategies
- Lead contract negotiations, evaluate performance metrics, and ensure organizational alignment
- Help develop the organizational structure and capabilities required to support effective payer engagement across the expanding U.S. Arrowhead portfolio
- Monitor sales implications for each payer negotiation and take action to establish optimal access in the right direction as necessary
- Collaborate with cross-functional teams, including Sales, Medical Affairs, Commercial Analytics, Finance, and Compliance, to address access challenges
- Provide market intelligence updates on payer trends, coverage determinations, and healthcare policy changes
- Present payer policy insights at internal business reviews, national conferences, and sales meetings to align strategic priorities
- Ensure full compliance with US healthcare regulations, legal standards, and corporate policies
Requirements:
- 12+ years pharmaceutical/biotech experience with a strong background in field-based market access, payer engagement, or managed markets
- 5+ years of previous national account payer experience with established relationships at GPOs, PBMs and plans are required
- Strong understanding of commercial, Medicare Part D, and Medicaid managed care processes
- Previous experience launching rare disease/cardiometabolic medicines highly desired
- Experience managing national and local contracting initiatives in managed care organizations
- Demonstrated leadership experience with a proven ability to build, develop, and lead a high-performing market access team to support an expanding portfolio of innovative therapies
- Excellent communication, negotiation, and presentation skills
- Ability to translate complex scientific and economic data into payer-relevant insights
- Self-motivated, collaborative, and able to operate with strategic independence
- Willingness to travel up to 50%
- Bachelor’s degree
Preferred:
- Master’s / Advanced Degree (MBA, MPH, PharmD)
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.
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What We Do
Arrowhead Pharmaceuticals is a clinical stage, Nasdaq listed (ticker ARWR) company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, our therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Our RNAi-based therapeutics are at the leading edge of genetic-based therapy with the potential to bring life changing treatments for patients.
Our Targeted RNAi Molecule (TRiMTM) platform utilizes ligand-mediated delivery and is designed to enable tissue-specific targeting while being structurally simple. The TRiM platform builds on more than a decade of work on actively targeted drug delivery and offers several advantages including simplified manufacturing and reduced costs; multiple routes of administration; and potential for improved safety.
Our employees are nimble, science-driven, and innovative professionals. A career at Arrowhead offers the opportunity to collaborate with top notch scientists to rapidly discover and develop RNAi-based therapeutics to add to our growing pipeline.
Research and development activities are located in Madison, WI. Our R&D group includes fully-integrated capabilities for chemistry, biology, and toxicology. Madison is an exciting and sophisticated city that includes state government, the flagship campus of the University of Wisconsin, and major research organizations.
Our HQ, clinical and regulatory operations are located in Pasadena, CA. Just north of Los Angeles and resting in the foothills of the San Gabriel Mountains, Pasadena is known for its natural scenic beauty, vibrant cultural and academic environment and rich architectural setting.
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