At Diffuse Bio we’re building generative AI for protein therapeutics. Our team has been behind breakthroughs in AI protein design for the past 6 years, including the first experimental validation of AI-generated proteins and diffusion models for protein structure and sequence. We’ve built the first entirely AI computational nanobody design platform and are testing designs in lab now.
Our goal is to build AI systems that can design protein therapeutics for the most challenging and high-value targets. We see enormous potential for AI to revolutionize drug discovery and expand the set of diseases we can treat.
We are looking for candidates who are excited about the opportunity to join the founding team and play an expanding role in the company.
The role:
Extend and scale Diffuse’s in-house deep generative modeling toolkit for downstream applications in molecular design.
Thoughtfully execute deep learning experiments to improve performance of models or develop new functionality (e.g. loop engineering, structure prediction of protein-protein complexes).
Have ownership of a scoped-out project centered on advancing internal methods.
Located in the Bay Area (remote work is an option for exceptional candidates).
4 month minimum (3 months for exceptional candidates).
Ideal background:
Self-starter who enjoys working on tough scientific problems and is results-driven.
Able to think critically, methodically, and creatively about experiments.
Proficient in Python.
Experience working with deep learning frameworks (e.g., PyTorch).
Track record of impressive work in industry/academia centered on ML / deep learning.
Currently pursuing a graduate degree in math, CS, stats, bioengineering, comp bio, or a related field (not a hard requirement for exceptional candidates).
Industry experience in a data science or engineering position
Pluses:
Knowledge of physics, math, molecular biology, chemistry, etc.
Previous work on ML applied to problems in structural biology or molecular design.
Strong publication record.
What we offer:
The opportunity to work on cutting-edge AI with leading researchers from top institutions.
Skills Required
- Proficient in Python
- Experience with deep learning frameworks (e.g., PyTorch)
- Track record of ML / deep learning work in industry or academia
- Self-starter with strong critical and experimental thinking
- Currently pursuing a graduate degree in math, CS, stats, bioengineering, comp bio, or related field
- Industry experience in a data science or engineering position
- Knowledge of physics, math, molecular biology, or chemistry
- Previous work on ML applied to structural biology or molecular design
- Strong publication record
What We Do
Diffuse Bio is a biotechnology company that leverages generative AI to design and engineer novel protein therapeutics. By developing foundational models and software platforms like DiffuseSandbox and RamaX, the company aims to transition protein design from slow wet-lab workflows to high-precision computational design. Their mission is to create new and useful proteins with unprecedented control and accuracy to accelerate the drug discovery and development process.
