Master Thesis: Interference of Therapeutic Antibodies in Olink Biomarker Assays
Work Schedule
Standard (Mon-Fri)Environmental Conditions
Some degree of PPE (Personal Protective Equipment) required (safety glasses, gowning, gloves, lab coat, ear plugs etc.)Job Description
Location: Olink, part of Thermo Fisher Scientific, Uppsala, Sweden (On site).
Duration: Jan–June 2026
Supervisor: Emmy Rannikko
Project Overview
Are you interested in working at the intersection of bioanalysis and drug development? This thesis project addresses a highly relevant challenge: how therapeutic antibodies may interfere with biomarker measurements in plasma using Olink assays. You will have the opportunity to combine work with Olink’s Proximity Extension Assay (PEA) technology and advanced biophysical methods to explore mechanisms in a real research setting.
Objectives
Screening: Test a selection of known therapeutic antibodies in plasma (spike-in) and analyze interference using mid-plex PEA readouts.
Deep Dive: Perform titrations for selected antibodies and investigate detailed effects.
Mechanistic Studies: For selected cases, verify interactions using SPR (Surface Plasmon Resonance) technology.
Optional (time permitting): Explore and compare with plasma samples endogenously treated with therapeutic antibodies based on assay signatures.
Why It’s Exciting
The results will provide insights into how therapeutic antibodies affect biomarker measurements—critical for both clinical studies and diagnostics. You will gain hands-on experience with modern proteomics platforms and biophysical interaction analysis.
About You
Interested in bioanalysis, proteomics, and pharmaceutical research.
Enjoy combining experimental work with data analysis and problem-solving.
Currently pursuing a master’s degree in biotechnology, biomedicine, molecular biology, or a related field.
About Thermofisher:
ThermoFisher Scientific is a world leader in serving science, with a mission to enable our customers to make the world healthier, cleaner, and safer. Our extensive portfolio includes innovative technologies, cutting-edge research, and comprehensive laboratory services that support a wide range of industries, including pharmaceuticals, biotechnology, healthcare, environmental, and industrial applications.
At ThermoFisher Scientific, we are committed to providing exceptional solutions that drive scientific discovery and improve patient outcomes. Our global team of over 130,000 employees works collaboratively to deliver high-quality products and services, ensuring that our customers can achieve their scientific goals with confidence and precision.
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By joining ThermoFisher Scientific, you will be part of a dynamic and inclusive workplace where your contributions can make a significant impact on advancing science and technology for the betterment of society.
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What We Do
Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of approximately $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD.
Why Work With Us
You will join a company which every colleague has the opportunity to create possibilities, for oneself, for our customers and patients. There is no more exciting place to be than at the forefront of solving problems which help improve lives around the world. As a company, we are committed to supporting your career aspirations and your journey.
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