Master Thesis Automatic CT/MR image registration

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Stockholm, SWE
In-Office
Entry level
Healthtech • Biotech
The Role
Master’s thesis focused on automating CT/MR brain-image registration for Elekta’s Leksell Gamma Plan. The student will develop automatic fiducial-mark detection and image-registration methods, define quality-assurance metrics, and evaluate accuracy and robustness against the existing semi-automatic process across more than 100 cases. The project is conducted with software-development and clinical-application experts in Stockholm.
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We don’t just build technology. We build hope for everyone dealing with Cancer.

Elekta is shaping the standard of care, together with healthcare providers, by developing precision radiation medicine that brings advanced radiotherapy into routine clinical practice. Our solutions support consistent, efficient and personalized care, addressing evolving patient needs. Through adaptive radiotherapy, precision treatment delivery and integrated workflows, Elekta supports care teams across a range of clinical settings. Each year more than 2 million patients are treated using Elekta solutions across over 130 countries. Elekta is headquartered in Stockholm, Sweden, with over 4,000 employees and offices in more than 40 countries. The company is listed on Nasdaq Stockholm. For more information, visit elekta.com.

Introduction 

Leksell Gamma Plan (LGP) is a successful treatment planning system for stereotactic neuro radiotherapy performed by the Leksell Gamma Knife. Both are made by Elekta in Stockholm. 


LGP is used by neurosurgeons and radio oncologists worldwide to analyse brain imaging and identify targets and choose doses of gamma radiation, as well as planning the application of the required doses to these targets by the Leksell Gamma Knife over a series of one or more treatment fractions. 

 

Background 

An important step in each treatment is correctly determining the position of structures shown in CT/MR brain imaging in a co-ordinate system relative to the machine. A mechanical frame with fiducial marks is firmly attached to the patient’s head prior to imaging, and the marks are visible in the resulting images. The frame is firmly attached to the Gamma Knife during treatment, allowing the correct calculation of positions of structures in the brain in a known co-ordinate system (calculation of the transformation from image co-ordinates to machine co-ordinates is known as registration). 

 

Problem Statement 

Present image registration algorithm for tomographic (MR/CT) images is semi-automatic and we would like to automate it and see if better registration transforms can be found. 


Output 

This thesis project aims to: 

     a) Propose and prototype method(s) for fully automatic detection of fiducial marks in MR/CT images. 

     b) Propose and prototype method(s) for fully automatic image registration based on fiducials. 

     c) Propose relevant metric(s) for quality assurance (e.g. mean and max errors). 

     d) Evaluate robustness and accuracy for proposed method(s) compared to current fiducial based  

           registration in LGP (for >100 representative and varying cases). 

  

Who are we looking for? 

Masters student, probably specialized in image handling/graphics. 


No prior knowledge of Gamma Knife treatment planning is required. Domain experts from Elekta will provide introductions to the relevant aspects of the software architecture and workflow. The student will work closely with experts in software development and clinical applications throughout the project.    


Practicalities 

Location: Elekta office, Stockholm 

Supervisor: Ethan Palmiere, [email protected] 

Start date: Early 2027 

Skills Required

  • Currently enrolled as a master’s student
  • Specialization or background in image handling or graphics

Elekta Compensation & Benefits Highlights

The following summarizes recurring compensation and benefits themes identified from responses generated by popular LLMs to common candidate questions about Elekta and has not been reviewed or approved by Elekta.

  • Retirement Support — A 401(k) with employer match is a prominent benefit, with vesting noted as part of the plan.
  • Leave & Time Off Breadth — PTO and paid holidays are included, with PTO accruing from the start and rollover allowed within limits.
  • Healthcare Strength — Medical, dental, vision, life and disability coverage are included, complemented by an Employee Assistance Program.

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The Company
HQ: Stockholm
4,700 Employees
Year Founded: 1972

What We Do

At Elekta, our outcome-driven and cost-efficient solutions provide lasting clinical difference and are developed through sustainable environmental, social and governance practices. We’ve been working openly and proactively with clinicians and our partners for almost half a century to advance precision radiation therapy and meet continuously evolving patient needs—no matter where they are in the world. To us, it's personal, and our global team of 4,700 employees combine passion, science, and imagination to profoundly change cancer care. We don’t just build technology, we build hope. Elekta is headquartered in Stockholm, Sweden, with offices in 120 countries and listed on Nasdaq Stockholm.

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