GeneDx (Nasdaq: WGS) delivers personalized and actionable health insights to inform diagnosis, direct treatment, and improve drug discovery. The company is uniquely positioned to accelerate the use of genomic and large-scale clinical information to enable precision medicine as the standard of care. GeneDx is at the forefront of transforming healthcare through its industry-leading exome and genome testing and interpretation services, fueled by the world’s largest, rare disease data sets. For more information, please visit www.genedx.com.
Summary
The Manager of Internal Audit will play a pivotal role in building, executing and enhancing the company’s newly revamped internal audit function, with a strong emphasis on Sarbanes-Oxley (SOX) compliance and operational audits. This individual will contribute to building a scalable and effective audit program, supporting risk management, control evaluation, and governance processes. The role requires someone who can manage co-sourced resources, collaborate across departments, and deliver value-added insights to improve business processes and controls. Reporting to the Head of Internal Audit, this role will work closely with finance, operational, and other members of management to maintain transparency, integrity, and accountability within the organization.
This position will be hybrid in office two days per week in Stamford, CT and may require occasion travel (~20%).
Job Responsibilities
- Lead and manage assigned areas of the SOX program, including risk assessment, scoping, testing, and reporting.
- Perform walkthroughs and document business processes, risks, control activities, and supporting technologies.
- Review workpapers and assess the design and operating effectiveness of internal controls.
- Draft and deliver audit results, ensuring timely and actionable feedback to stakeholders.
- Serve as a subject matter expert on SOX, risk, and control, advising business and risk partners.
- Ability to formulate opinions and communicate perspectives to stakeholders in a timely manner.
- Conduct audits and ad-hoc internal audit projects aligned with the annual audit plan.
- Manage multiple workstreams at the same time and prioritize tasks for team members.
- Provide training and guidance to internal audit staff and control owners on SOX requirements and best practices.
- Identify opportunities for process improvement and control enhancement.
- Collaborate with external auditors, co-sourced partners, and internal stakeholders.
- Support the growth of the internal audit function, including recruiting and onboarding efforts.
- Contribute to the evolution of audit practices by incorporating emerging technologies and process refinements.
- Participate in company-wide risk assessments and integrate findings into audit planning.
- Maintain awareness of regulatory changes and industry best practices.
Education, Experience, and Skills
- Bachelor’s degree in Accounting, Finance, Economics, IT or other related field; advanced degree a plus.
- Certified Internal Auditor (CIA) or Certified Public Accountant (CPA) required.
- 7+ years of experience in auditing and/or compliance, including SOX program management.
- Experience managing co-sourced resources and leading audit teams.
- Strong understanding of internal control frameworks, financial reporting, enterprise risk frameworks.
- Familiarity with enterprise resource planning (ERP) systems, GRC platforms, and audit management software. Experience with NetSuite or Audit Board a plus.
- Experience within the Healthcare industry.
- Excellent project management, analytical, and communication skills.
- Ability to build relationships across all levels of the organization.
- High attention to detail and commitment to accuracy and transparency.
- Ability to work in a fast paced, action-oriented environment.
Work Environment
This is a hybrid position requiring both in-office and remote work. The employee will work from our office location in Stamford, CT and remotely from a home office or other suitable location with reliable high-speed internet access. In-office work is performed in a professional office setting with standard lighting, temperature control, and low to moderate noise levels. Remote work is performed in a climate-controlled environment. Standard office equipment including computer, phone, and video conferencing tools are used in both settings. Your standard work schedule and hours will be established in collaboration with your leader and may be adjusted to align with evolving business needs.
Physical Demands
This is a sedentary role with physical demands including:
- Sitting for extended periods (up to 8 hours per day).
- Repetitive use of hands and fingers for typing and mouse operation.
- Visual acuity for reading computer screens and documents.
- Ability to communicate effectively in person, by phone, and via video.
- Occasional standing, walking, and reaching for files or supplies.
- Occasional lifting of up to 15 pounds (files, office supplies, equipment).
- Ability to commute to office location as required.
Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position.
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Science - Minded, Patient - Focused.
At GeneDx, we create, follow, and are informed by cutting-edge science. With over 20 years of expertise in diagnosing rare disorders and diseases, and pioneering work in the identification of new disease-causing genes, our commitment to genetic disease detection, discovery, and diagnosis is based on sound science and is focused on enhancing patient care.
Experts in what matters most.
With hundreds of genetic counselors, MD/PhD scientists, and clinical and molecular genomics specialists on staff, we are the industry’s genetic testing experts and proud of it. We share the same goal as healthcare providers, patients, and families: to provide clear, accurate, and meaningful answers we all can trust.
SEQUENCING HAS THE POWER TO SOLVE DIAGNOSTIC CHALLENGES.
From sequencing to reporting and beyond, our technical and clinical experts are providing guidance every step of the way:
TECHNICAL EXPERTISE
- High-quality testing: Our laboratory is CLIA certified and CAP accredited and most of our tests are also New York State approved.
- Advanced detection: By interrogating genes for complex variants, we can identify the underlying causes of conditions that may otherwise be missed.
CLINICAL EXPERTISE
- Thorough analysis: We classify variants according to our custom adaptation of the most recent guidelines. We then leverage our rich internal database for additional interpretation evidence.
- Customized care: Our experts review all test results and write reports in a clear, concise, and personalized way. We also include information for research studies in specific clinical situations.
- Impactful discovery: Our researchers continue working to find answers even after testing is complete. Through both internal research efforts and global collaborations, we have identified and published hundreds of new disease-gene relationships and developed novel tools for genomic data analysis. These efforts ultimately deliver more diagnostic findings to individuals.
Learn more About Us here.
At GeneDx, we're driven by urgency and purpose: helping patients get diagnosed earlier. Our mission, to empower everyone to live their healthiest life through genomics, drives our team to make a tangible impact each day – and shapes our culture where high standards, strong teamwork, and meaningful ownership are the norm. We act with intention, support one another, and deliver work we're proud to put our names on.
Here’s what you can expect day to day:
1. Play like a champion (step up, redefine what’s possible, own it)
We bring energy, focus, and a bias for action. We step up, take initiative, and deliver on our commitments – with quality, speed, and care.
We push past the obvious. We challenge assumptions, raise the bar, and make thoughtful, decisive calls — choosing progress over perfection.
We stay curious, ask questions, and share direct feedback with respect. We adapt quickly and keep learning through collaboration and continuous improvement.
If you’re motivated by meaningful work, a fast-moving environment, and teammates who care deeply about outcomes, you’ll thrive at GeneDx.
Benefits include:
- Paid Time Off (PTO)
- Health, Dental, Vision and Life insurance
- 401k Retirement Savings Plan
- Employee Stock Purchase Plan
- Employee Discounts
- Voluntary benefits
- Programs for parents and parents-to-be
- We provide expert support for family planning, pregnancy, and postpartum care, including up to 22 weeks of fully paid parental leave (U.S.) and up to $25K annually for fertility, adoption, or surrogacy.
GeneDx is an Equal Opportunity Employer.
All privacy policy information can be found here.
Skills Required
- Bachelor's degree in Accounting, Finance, Economics, IT or related field; advanced degree a plus
- Certified Internal Auditor (CIA) or Certified Public Accountant (CPA)
- 7+ years of experience in auditing and/or compliance, including SOX program management
- Experience managing co-sourced resources and leading audit teams
- Strong understanding of internal control frameworks, financial reporting, enterprise risk frameworks
- Familiarity with ERP systems, GRC platforms, and audit management software; experience with NetSuite or Audit Board a plus
- Experience within the Healthcare industry
- Excellent project management, analytical, and communication skills
- Ability to build relationships across all levels of the organization
What We Do
GeneDx is focused on delivering personalized, actionable insights that improve health outcomes. We sit at the intersection of diagnostics and data science, pairing decades of genomic expertise with an unmatched ability to interpret clinical data at scale. Our exome and genome testing is among the best in the industry. We expect that it will be even more advanced in the future with the help of Centrellis®, our innovative health information platform. Powered by millions of medical records, Centrellis® integrates digital tools with artificial intelligence to ingest and synthesize clinical and genomic data. As a result of our robust test menu, including our exome and genome testing, and the comprehensive insights generated by Centrellis®, we are developing a more complete understanding of complex disease than ever before. This translates to faster diagnosis, more effective treatment plans, and enhanced drug discovery. Our offerings help a whole spectrum of healthcare partners -- clinicians, researchers, health systems, pharmaceutical companies, and payors -- improve patient experiences and advance population health







