Company Overview
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Summary
Reporting to the CHRO, the Manager, Human Resources Business Partner (HRBP) supports the General & Administrative (G&A) functions, partnering with leaders and employees across areas such as Finance, Legal, IT, and HR, as applicable. The HRBP provides practical HR guidance, builds effective relationships, and helps implement people programs aligned with functional needs and company priorities. The role supports talent and career development, manager coaching, employee relations, performance management, and organizational change. The Manager independently handles routine HR matters and partners with the CHRO on complex, sensitive, or higher-impact decisions.
Your Role:
- Serves as the primary day-to-day HR partner for assigned G&A teams, providing timely guidance and delivering HR programs and services in support of functional priorities
- Uses HR data, employee feedback, and knowledge of G&A operations to identify people trends, highlight concerns, and recommend practical actions; escalates significant issues and recommendations to the CHRO
- Implements and improves HR processes and solutions in partnership with the CHRO and HR colleagues, recommending changes based on client needs
- Supports leaders with team effectiveness, role clarity, and organizational changes; partners with the CHRO on complex organization design or sensitive change initiatives
- Partners with G&A leaders to identify talent needs and implement practical approaches to employee development, engagement, and retention
- Supports annual workforce and headcount planning for G&A functions, including identifying hiring needs, skills gaps, and succession considerations; contributes analysis and recommendations for CHRO and functional leader review
- Collaborates closely with HR colleagues to deliver consistent employee experiences and implement company-wide HR programs across the G&A client group
- Coordinates performance and talent processes for G&A teams, including ongoing feedback, performance discussions, calibration, and compensation planning in partnership with the CHRO and relevant HR colleagues
- Partners with Talent Acquisition and G&A hiring managers to clarify role requirements, support hiring plans, and facilitate onboarding and integration
What You Bring:
Education and Experience:
- Undergraduate degree in human resources or related, relevant discipline
- Typically requires 5–7 years of progressive HR experience, including experience supporting leaders as an HR generalist or HR business partner, or an equivalent combination of education and experience
Knowledge and Skills:
- Experience implementing HR programs and advising managers on day-to-day people matters
- Experience supporting headcount planning, talent reviews, or workforce planning activities
- Working knowledge of talent management, performance management, succession planning, and employee development
- Experience supporting organizational change, employee engagement, or team effectiveness initiatives
- Sound knowledge of manager coaching, employee relations, and HR data analysis; ability to recognize when to escalate complex or sensitive matters
Traits and Qualities:
- Ability to influence positively including in situations without direct authority
- Ability to manage routine responsibilities independently while seeking guidance on complex, sensitive, or precedent-setting matters; collaborates effectively across teams
- Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines
- Excellent planning, organization and time management skills including the ability to support, prioritize, and multi-task
- Highly collaborative team player who fosters open communication and develops important relationships with key stakeholders
- Outstanding interpersonal and communication abilities with a high degree of emotional intelligence
- Demonstrates sound judgment, discretion, and interpersonal skills to build credibility with employees and G&A managers
- Have proven communication skills, both written and verbal, and the ability to present information clearly to a variety of audiences
- Able to learn quickly, organize work, and execute defined HR projects with appropriate guidance and follow-through
- Thrives in high energy and fast paced organization with ongoing simultaneous initiatives
- Builds alignment through clear communication, collaboration, and practical recommendations
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Skills Required
- Undergraduate degree in human resources or a related relevant discipline
- Typically 5–7 years of progressive HR experience
- Experience supporting leaders as an HR generalist or HR business partner, or equivalent education and experience
- Experience implementing HR programs and advising managers on day-to-day people matters
- Experience supporting headcount planning, talent reviews, or workforce planning activities
- Working knowledge of talent management, performance management, succession planning, and employee development
- Experience supporting organizational change, employee engagement, or team effectiveness initiatives
- Knowledge of manager coaching, employee relations, and HR data analysis
- Ability to recognize when to escalate complex or sensitive matters
- Strong communication, interpersonal, planning, organization, problem-solving, and collaboration skills
- Ability to manage multiple priorities and execute HR projects in a fast-paced environment
What We Do
Tango Therapeutics is a biotechnology company discovering and developing novel medicines targeting cancer vulnerabilities to deliver transformational new therapies for patients. Tango was launched in 2017 with a $55 million Series A investment from Third Rock Ventures. The company has established a robust product engine that leverages advances in DNA sequencing and CRISPR-based target discovery to generate breakthrough medicines that have the potential to provide deeper, more sustained benefit than today’s targeted therapies, and extend the benefit of available immuno-oncology agents. Tango Therapeutics is focused on three areas of drug development, each in well-defined patient populations currently lacking effective treatment options, and each with hallmarks of cancer that have not been targeted yet. These include: loss of tumor suppressor gene function; multiple oncogenic drivers; and immune evasion. What fuels each of Tango’s programs is an increasingly sophisticated ability to utilize synthetic lethality - the interaction between two genes that causes cell death when both are inactivated. In cancer cells, one of these genes is inactivated by mutation; the other will be inactivated by a drug. This approach leaves normal cells largely unaffected, with the potential to greatly enhance anti-tumor efficacy and reduce associated toxicity. Tango’s success will be driven by its depth of understanding of the genetic subtypes of cancer, and corresponding insights into novel drug targets and combinations uniquely relevant to each subtype. By shaping discovery efforts in this way, Tango has the potential to reach the clinic quickly, and with a clear plan for identifying the patients most likely to benefit from each new treatment, an approach that could increase both speed and probability of success in translating novel target discoveries into transformational new medicines for patients.
